Increased hepatic telomerase activity in a rat model of iron overload: A role for altered thiol redox state?

Free Radical Biology and Medicine

Volumn 42, Issue 2, 2007, Pages 228-235

  Brown, Kyle E ^a,b   Meleah Mathahs, M ^a   Broadhurst, Kimberly A ^a   Coleman, Mitchell C ^b   Ridnour, Lisa A ^c   Schmidt, Warren N ^a,b   Spitz, Douglas R ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Free radicals; Glutamate cysteine ligase; Glutathione; Hemochromatosis; Oxidative stress; Telomeres

Indexed keywords

CYSTEINE; DNA; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IRON; MESSENGER RNA; N ETHYLMALEIMIDE; TELOMERASE; THIOL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; IRON OVERLOAD; LIVER REGENERATION; MALE; MITOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SENESCENCE; TELOMERE;

ANIMALS; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTATHIONE; IRON; IRON OVERLOAD; LIVER; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFHYDRYL COMPOUNDS; TELOMERASE; TELOMERE;

RODENTIA;

EID: 33845630659     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.10.039     Document Type: Article

References (41)

1. Wong J.M.Y., and Collins K. Telomere maintenance and disease. Lancet 362 (2003) 983-988
2. Blasco M.A. Telomeres and human disease: ageing, cancer and beyond. Nat. Rev., Genet. 6 (2005) 611-622
3. von Zglinicki T., Saretzki G., Döcke W., and Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?. Exp. Cell Res. 220 (1995) 186-193
4. von Zglinicki T., Serra V., Lorenz M., Saretzki G., Lenzen-Grossimlighaus R., Gessner R., Risch A., and Steinhagen-Thiessen E. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?. Lab. Invest. 80 (2000) 1739-1747
5. von Zglinicki T., Pilger R., and Sitte N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic. Biol. Med. 28 (2000) 64-74
6. 2+-mediated Fenton reactions has possible biological implications. J. Biol. Chem. 274 (1999) 962-971
7. Borrás C., Esteve J.M., Viña J.R., Sastre J., Viña J., and Pallardó F.V. Glutathione regulates telomerase activity in 3T3 fibroblasts. J. Biol. Chem. 279 (2004) 34332-34335
8. Hayakawa N., Nozawa K., Ogawa A., Kato N., Yoshida K., Akamatsu K., Tsuchiya M., Nagasaka A., and Yoshida S. Isothiazolone derivatives selectively inhibit telomerase activity from human and rat cancer cells in vitro. Biochemistry 38 (1999) 11501-11507
9. Kitada T., Seki S., Kawakita N., Kuroki T., and Monna T. Telomere shortening in chronic liver diseases. Biochem. Biophys. Res. Commun. 211 (1995) 33-39
10. Aikata H., Takaishi H., Kawakami Y., Takahashi S., Kitamoto M., Nakanishi T., et al. Telomere reduction in human liver tissues with age and chronic inflammation. Exp. Cell Res. 256 (2000) 578-582
11. Wiemann S.U., Satyanarayana A., Tsahuridu M., Tillmann H.L., Zender L., Klempnauer J., Flemming P., Franco S., Blasco M.A., Manns M.P., and Rudolph K.L. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J. 16 (2002) 935-942
12. Rudolph K.L., Chang S., Millard M., Schreiber-Agus N., and DePinho R.A. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 287 (2000) 1253-1258
13. Sato R., Maesawa C., Fujisawa K., Wada K., Oikawa K., Takikawa Y., Suzuki K., Oikawa H., Ishikawa K., and Masuda T. Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis. Gut. 53 (2004) 1001-1009
14. Brown K.E., Kinter M.T., Oberley T.D., Freeman M.L., Frierson H.F., Ridnour L.A., Tao Y., Oberley L.W., and Spitz D.R. Enhanced γ-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload. Free Radic. Biol. Med. 24 (1998) 545-555
15. Brown K.E., Dennery P.A., Ridnour L.A., Fimmel C.J., Kladney R.D., Brunt E.M., and Spitz D.R. Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver Int. 23 (2003) 232-242
16. Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., and Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 10114-10118
17. Analysis of DNA sequences by blotting and hybridization. In: Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., and Struhl K. (Eds). Current Protocols in Molecular Biology (2000), Wiley, Hoboken 2.9.2-2.9.5
18. Cherif H., Tarry J., Ozanne S., and Hales C. Ageing and telomeres: a study into organ-and gender-specific telomere shortening. Nucleic Acids Res. 31 (2003) 1566-1583
19. Ridnour L.A., Sim J.E., Choi J., Dickinson D.A., Forman H.J., Ahmad I.M., Coleman M.C., Hunt C.R., Goswami P.C., and Spitz D.R. Nitric oxide induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity dependent process. Free Radic. Biol. Med. 38 (2005) 1361-1371
20. Stål P., Hultcrantz R., Möller L., and Eriksson L.C. The effects of dietary iron on initiation and promotion in chemical hepatocarcinogenesis. Hepatology 21 (1995) 521-528
21. Whittaker P., Dunkel V.C., Bucci T.J., Kusewitt D.F., Thurman J.D., Warbritton A., and Wolff G.L. Genome-linked toxic responses to dietary iron overload. Toxicol. Pathol. 25 (1997) 556-564
22. Brown K.E., Mathahs M.M., Broadhurst K.A., and Weydert J. Chronic iron overload stimulates hepatocyte proliferation and cyclin D1 expression in rodent liver. Transl. Res. 148 (2006) 55-62
23. Martín-Rivera L., Herrera E., Albar J.P., and Blasco M.A. Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 10471-10476
24. Golubovskaya V.M., Presnell S.C., Hooth M.J., Smith G.J., and Kaufmann W.K. Expression of telomerase in normal and malignant rat hepatic epithelia. Oncogene 15 (1997) 1233-1240
25. Yamaguchi Y., Nozawa K., Savoysky E., Hayakawa N., Nimura Y., and Yoshida S. Change in telomerase activity of rat organs during growth and aging. Exp. Cell Res. 242 (1998) 120-127
26. Muira M., Karasaki Y., Abe T., Higashi K., Ikemura K., and Gotoh S. Prompt activation of telomerase by chemical carcinogens in rats detected with a modified TRAP assay. Biochem. Biophys. Res. Commun. 246 (1998) 13-19
27. Liu J.-P. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J. 13 (1999) 2091-2104
28. Kang S.S., Kwon T., Kwon D.Y., and Do S.I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274 (1999) 13085-13090
29. Haendeler J., Hoffmann J., Rahman S., Zeiher A.M., and Dimmeler S. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett. 536 (2003) 180-186
30. Akiyama M., Hideshima T., Hayashi T., Tai Y.-T., Mitsiades C.S., Mitsiades N., Chauhan D., Richardson P., Munshi N.C., and Anderson K.C. Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res. 62 (2002) 3876-3882
31. Akiyama M., Hideshima T., Hayashi T., Tai Y.-T., Mitsiades C.S., Mitsiades N., Chauhan D., Richardson P., Munshi N.C., and Anderson K.C. Nuclear factor-κB p65 mediates tumor necrosis factor α-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 63 (2003) 18-21
32. Forsythe H.L., Jarvis J.L., Turner J.W., Elmore L.W., and Holt S.E. Stable association of hsp90 and p23, but not hsp70, with active human telomerase. J. Biol. Chem. 276 (2001) 15571-15574
33. Paradis V., Youssef N., Dargère D., Bâ N., Bonvoust F., Deschatrette J., and Bedossa P. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum. Pathol. 32 (2001) 327-329
34. Satyanarayana A., Wiemann S.U., Buer J., Lauber J., Dittmar K.E.J., Wüstefeld T., Blasco M.A., Manns M.P., and Rudolph K.L. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J. 22 (2003) 4003-4013
35. Canbay A., Freidman S., and Gores G.J. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39 (2004) 273-278
36. Holt S.E., Glinsky V.V., Ivanova A.B., and Glinsky G.V. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol. Carcinog. 25 (1999) 241-248
37. Lu C., Fu W., and Mattson M.P. Telomerase protects developing neurons against DNA damage-induced cell death. Dev. Brain Res. 131 (2001) 167-171
38. Ren J.-G., Xia H.-L., Tian Y.-M., Just T., Cai G.-P., and Dai Y.-R. Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts. FEBS Lett. 488 (2001) 133-138
39. Gorbunova V., Seluanov A., and Pereira-Smith O.M. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J. Biol. Chem. 277 (2002) 38540-38549
40. + helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 101 (2003) 4512-4519
41. Liu L., Trimarchi J.R., Navarro P., Blasco M.A., and Keefe D.L. Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis. J. Biol. Chem. 278 (2003) 31998-32004