Epistatic control of human obesity as revealed by linkage disequilibrium mapping: A report from the NHLBI-sponsored WISE study

Current Genomics

Volumn 7, Issue 7, 2006, Pages 463-468

  Li, Hongying ^a   Wu, Rongling ^a   Lin, Min ^a   Terra, Steve G ^b   Pepine, Carl J ^c   McGorray, Susan P ^a   Johnson, B Delia ^d   Johnson, Julie A ^b  

^a University of Florida ^*  (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Adrenergic receptors; Candidate genes; Obesity; Quantitative trait loci (QTL); Single nucleotide polymorphisms (SNPs)

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA3 SUBUNIT;

ADIPOSE TISSUE; BODY MASS; BODY WEIGHT; CAUCASIAN; CHROMOSOME 10Q; CHROMOSOME 12P; CHROMOSOME 20Q; CHROMOSOME 5Q; CHROMOSOME 8P; ETHNIC DIFFERENCE; GENE FREQUENCY; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC EPISTASIS; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HUMAN; LIPOLYSIS; NEGRO; OBESITY; POPULATION DIFFERENTIATION; QUANTITATIVE TRAIT LOCUS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; THERMOGENESIS; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

EID: 33845601554     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920206779116783     Document Type: Review

References (34)

1. Wickelgren, I. Obesity: How big a problem? Science 1998, 280: 1364-1367.
2. Ebbeling, C.B., Pawlak, D.B., Ludwig, D.S. Childhood obesity: public health crisis, common sense cure. Lancet 2002, 360: 473-482.
3. Eckel, R.H., Barouch, W.W., Ershow, A.G. Report of the National Heart Lung Blood Institute - National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the Pathophysiology of Obesity-Associated Cardiovascular Disease. Circulation 2002, 105: 2923-2928.
4. Comuzzie, A.G., Allison, D.B. The search for human obesity genes. Science 1998, 280: 1374-1377.
5. Lev-Ran, A. Human obesity: an evolutionary approach to understanding our bulging waistline. Diabetes Metab. Res. Rev. 2001, 17: 347-362.
6. Stunkard, A.J., Foch, T.T., Hrubec, Z. A twin study for human obesity. J. Am. Med. Assoc. 1986, 256: 51-54.
7. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372: 425-434.
8. Gutersohn, A., Naber, C., Muller, N., Erbel, R., Siffert, W.G. Protein beta3 subunit 825 TT genotype and post-pregnancy weight retention. Lancet 2000, 355: 1240-1241.
9. Dionne, I.J., Garant, M.J., Nolan, A.A., Pollin, T.I., Lewis, D.G., Shuldiner, A.R., Poehlman, E.T. Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women. Int. J. Obes. Relat. Metab. Disorder 2002, 26: 633-639.
10. Comuzzie, A.G., Hixson, J.E., Almasy, L., Mitchell, B.D., Mahaney, M.C., Dyer, T.D., Stern, M.P., MacCluer, J.W., Blangero, J. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nature Genet. 1997, 15: 273-276.
11. Wiltshire, S., Hattersley, A.T., Hitman, G.A.,. Walker, M., Levy, J.C., Sampson, M., O'Rahilty, S., Frayling, T.M., Bell, J.I., Lathrop, G.M., Bennett, A., Dhillon, R., Fletcher, C., Groves, C.J., Jones, E., Prestwich, P., Simecek, N., Rao, P.V., Wishart, M., Bottazzo, G.F., Foxon, R., Howell, S., Smedley, D., Carden, L.R., Menzel, S., McCarthy, M.I. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nature Genet. 2001, 20: 304-308.
12. Wu, X.D., Cooper, R.S., Borecki, I., Hanis, C., Bray, M., Lewis, C.E., Zhu, X.F., Kan, D.H., Luke, A., Curb, D. A combined analysis of genomewide linkage scans for body mass index, from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am. J. Hum. Genet. 2002, 70: 1247-1256.
13. Rankinen, T., Perusse, L., Weisnagel, S.J., Snyder, E.E., Chagnon, Y.C., Bouchard, C. The human obesity gene map: The 2001 update. Obesity Res. 2002, 10: 196-243.
14. Chagnon, Y.C., Rankinen, T., Snyder, E.E., Weisnagel, S.J., Perusse, L., Bouchard, C. The human obesity gene map: The 2002 update. Obes. Res. 2003, 11: 313-367.
15. Dong, C., Wang, S., Li, W.D., Li, D., Zhao, H., Price, R.A. Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. Am. J. Hum. Genet. 2003, 72: 115-124.
16. Mackay, T.F.C. The genetic architecture of quantitative traits. Annu. Rev. Genet. 2001, 35: 303-339.
17. Ardlie, K.G., Kruglyak, L., Seielstad, M. Patterns of linkage disequilibrium in the human genome. Nat. Rev. Genet. 2002, 3: 299-309.
18. Wu, R.L., Ma, C.X, Casella, G. Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations. Genetics 2002, 160: 779-792.
19. Lou, X-Y., Casella, G., Littell, R.C., Yang, M.C.K., Johnson, J.A., Wu, R.L. A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis. Genetics 2003, 163: 1533-1548.
20. Van Baak, M.A. The peripheral sympathetic nervous system in human obesity. Obes. Res. 2001, 2: 3-14.
21. Drysdale, C.M., McGraw, D.W., Stack, C.B., Stephens, J.C., Judson, R.S., Nandabalan, K., Arnold, K., Ruano, G., Liggett, S.B. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl. Acad. Sci. USA 2000, 97: 10483-10488.
22. 1-adrenergic receptor polymorphisms. Clin. Pharmacol. Ther. 2002, 71: 70.
23. Xie, H.G., Stein, C.M., Kim, R.B., Ziao, Z.S., He, N., Zhou, H.H. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics 1999, 9: 511-516.
24. Siffert, W., Forster, P., Jockel, K.H., Mvere, D.A., Brinkmann, B., Naber, C., Crookes, R., Du, P., Heyns, A., Epplen, J.T., Fridey, J., Freedman, B.I., Muller, N., Stolke, D., Sharma, A.M., Al Moutaery, K., Grosse-Wilde, H., Buerbaum, B., Ehrlich, T., Ahmad, H.R., Horsthemke, B., Du Toit, E.D., Tiilikainen, A., Ge, J., Wang, Y., Rosskopf, D. et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J. Am. Soc. Nephrol. 1999, 10: 1921-1930.
25. Lowell, B.B., Bachman, E.S. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J. Biol. Chem. 2003, 278: 29385-29388.
26. Large, V., Hellstrom, L., Reynisdottir, S., Lonnqvist, F., Eriksson, P., Lannfelt, L., Arner, P. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J. Clin. Invest. 1997, 100: 3005-3013.
27. Mitchell, B.D., Blangero, J., Comuzzie, A.G., Almasy, L.A., Shuldiner, A.R., Silver, K., Stern, M.P., MacCluer, J.W., Hixson, J.E. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans. J. Clin. Invest. 1998, 101: 584-587.
28. Hegele, R.A., Anderson, C., Young, T.K., Connelly, P.W. G-protein beta3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Genome Res. 1999, 9: 972-977.
29. Gutersohn, A., Naber, C., Muller, N., Erbel, R., Siffert, W. G protein beta3 subunit 825 TT genotype and post-pregnancy weight retention. Lancet 2000, 355: 1240-1241.
30. Yi, N.Y., Diament, A., Chiu, S., Kim, K., Allison, D.B., Fisler, J.S., Warden, C.H. Characterization of epistasis influencing complex spontaneous obesity in the BSB model. Genetics 2004, 167: 399-409.
31. Reich, D., Cargill, M., Bolk, S., Ireland, J., Sabeti, P., Richter, D., Lavery, T., Kouyoumjian, R., Farhadian, S., Ward, R., Lander, E. Linkage disequilibrium in the human genome. Nature 2001, 411: 199-204.
32. Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., Liu-Cordero, S.N., Rotimi, C., Adeyemo, A., Cooper, R., Ward, R., Lander, E.S., Daly, M.J., Altshuler, D. The structure of haplotype blocks in the human genome. Science 2002, 296: 2225-2229.
33. The International HapMap Consortium: The International HapMap Project. Nature 2003, 426: 789-794.
34. Tishkoff, S.A., Williams, S.M. Genetic analysis of African populations: Human evolution and complex disease. Nat. Rev. Genet. 2002, 3: 611-621.