Induction of G2/M phase arrest and apoptosis by a novel indoloquinoline derivative, IQDMA, in K562 cells

Drug Development Research

Volumn 67, Issue 9, 2006, Pages 743-751

  Lin, Yi Hsiung ^a   Yang, Sheng Huei ^a   Chien, Ching Ming ^a   Hu, Xiu Wei ^a   Huang, Ying Hui ^a   Lu, Chih Ming ^a   Chen, Yeh Long ^a   Lin, Shinne Ren ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; G2 M arrest; IQDMA; K562 cells

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN A; CYCLIN B1; CYCLIN D3; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2B; FAS ANTIGEN; INDOLOQUINOLINE DERIVATIVE; N' (11H INDOLO[3,2 C]QUINOLIN 6 YL) N,N DIMETHYLETHANE 1,2 DIAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P21; PROTEIN P27; PROTEIN TYROSINE PHOSPHATASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN K 562; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME KINETICS; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UPREGULATION;

EID: 33845571398     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20113     Document Type: Article

References (36)

1. Ashkenazi A, Dixit VM. 1998. Death receptor: signaling and modulation. Science 281:1305-1308 .
2. Balasubramanian M, Keay JG. 1996. Pyridines and their benzo derivatives: applications. In: Katritzky AR, Rees CW, Scriven EF. editors. Comprehensive heterocyclic chemistry. New York: Pergamon Press. p 245-300.
3. Chen YL, Chung CH, Chen IL, Chen PH, Jeng HY. 2002. Synthesis and cytotoxic activity evaluation of indolo-, pyrrolo-, and benzofuro-quinolin-2(1H) -ones and 6-anilinoindoloquinoline derivatives. Bioorg Med Chem 10:2705-2712.
4. Coqueret O. 2003. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 13:65-70.
5. Deady LW, Kaye AJ, Finlay GJ, Baguley BC, Denny WA. 1997. Synthesis and antitumor properties of N-[2-(dimethylamino) ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors. J Med Chem 40:2040-2046.
6. Doree M, Galas S. 1994. The cyclin-dependent protein kinases and the control of cell division. FASEB J 8:1114-1121.
7. Fortune JM, Velea L, Graves DE, Utsugi T, Yamada Y, Oscheroff N. 1999. DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition. Biochemistry 38:15580-15586.
8. Fujimoto K, Hosotani R, Doi R, Wada M, Lee JU, Koshiba T, Miyamoto Y, Tsuji S, Nakajima S, Imamura M. 1999. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cell. Int J Cancer 81:637-644.
9. Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Terce F. 2000. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 60:1426-1433.
10. Gewies A, Rokhlin OW, Cohen MB. 2000. Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines. Cancer Res 60:2163-2168.
11. Green DR, Reed JC. 1998. Mitochondria and apoptosis. Science 281:1308-1312.
12. Hartwell LH, Weinert TA. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science 246:629-634.
13. Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407:770-776.
14. Hyun JW, Cheon GJ, Kim HS, Lee YS, Choi EY, Yoon BH, Kim JS, Chung MH. 2002. Radiation sensitivity depends on OGGlactivity status in human leukemia cell lines. Free Rad Biol Med 32:212-220.
15. King RW, Jackson PK, Kirschner MW. 1994. Mitosis in transition. Cell 79:563-571.
16. Kroemer G, Reed JC. 2000. Mitochondrial control of cell death. Nat Med 6:513-519.
17. Lewin B. 1990. Driving the cell cycle: M phase kinases, its partners, and substrates. Cell 61:743-752.
18. Li H, Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
19. Ling YH, Consoli U, Tornos C, Andreeff M, Perez-Soler R. 1998. Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol. Int J Cancer 75:925-932.
20. Lock RB, Ross WE. 1990. Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Res 50:3761-3766.
21. Michael JP. 1997. Quinoline, quinazoline and acridone alkaloids. Nat Prod Rep 14:11-20.
22. Molinari M. 2000. Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 33:261-274.
23. Murray AW. 2004. Revisiting the cell cycle: cyclins revisited. Cell 116:221-234.
24. O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW. 1993. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2, and cyclin B1/cdc-2 kinase complexes differently. J Biol Chem 268:8298-8308.
25. Olson M, Kornbluth S. 2001. Mitochondria in apoptosis and human disease. Curr Mol Med 1:91-122.
26. Orren DK, Petersen LN, Bohr VA. 1997. Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis. Mol Biol Cell 8:1129-1142.
27. Ravagnan L, Roumier T, Kroemer G. 2002. Mitochondria, the killer organelles and their weapons. J Cell Physiol 192:131-137.
28. Robertson JD, Orrenius S. 2000. Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol 30:609-627.
29. Salvesen GS, Dixit VM. 1997. Caspases: intracellular signaling by proteolysis. Cell 91:443-446.
30. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. 1998. Apoptosis signaling by death receptors. Eur J Biochem 254:439-459.
31. Sherr CJ. 1996. Cancer cell cycles. Science 274:1672-1677.
32. Shi Y. 2002. 2002. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9:459-470.
33. Sleiman RJ, Catchpoole DR, Stewart BW. 1998. Drug-induced death of leukaemic cells after G2/M arrest: higher order DNA fragmentation as an indicator of mechanism. Br J Cancer 77:40-50.
34. + T lymphocytes. Toxicol Appl Pharmacol 193:97-105.
35. Yang SH, Chien CM, Lu MC, Lu YJ, Wu ZZ, Lin SR. 2005a. Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway. Clin Exp Pharm Physiol 32:515-520.
36. Yang SH, Lu MC, Chien CM, Tsai CH, Lu YJ, Hour TC, Lin SR. 2005b. Induction of apoptosis in human leukemia K562 cells by cardiotoxin III. Life Sci 76:2513-2522.