Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

Journal of Medicinal Chemistry

Volumn 49, Issue 25, 2006, Pages 7513-7517

  Peleg, Sara ^a   Petersen, Kimberly S ^b   Suh, Byung Chul ^b   Dolan, Patrick ^b   Agoston, Elin S ^b   Kensler, Thomas W ^b   Posner, Gary H ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCITRIOL DERIVATIVE; CALCIUM; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CULTURE; CULTURE MEDIUM; DRUG DESIGN; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCITRIOL; CALCIUM; CELL LINE; CELL PROLIFERATION; FEMALE; HUMANS; KERATINOCYTES; MICE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITRIOL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 33845486276     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0609925     Document Type: Article

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