Total synthesis of 25-hydroxy-16,23E-diene vitamin D3 and 1α,25-dihydroxy-16,23E-diene vitamin D3: Separation of genomic and nongenomic vitamin D activities

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 11, 1998, Pages 2051-2059

  Kabat, Marek M ^a   Burger, Walter ^a   Guggino, Sandra ^b   Hennessy, Bernard ^a   Iacobelli, Jerome A ^a   Takeuchi, Kazuhiro ^b   Uskokovic, Milan R ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium channel; Genomic effect; Nongenomic effect; Transcriptional effect; Vitamin D3 analogues

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 1ALPHA,25 DIHYDROXY 16,23E DIENE COLECALCIFEROL; 25 HYDROXY 16,23E DIENE COLECALCIFEROL; CALCIFEDIOL; CALCITRIOL; CALCIUM CHANNEL; COLECALCIFEROL; COLECALCIFEROL DERIVATIVE; NITRENDIPINE; OSTEOCALCIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIFEDIOL; CALCITRIOL; CALCIUM; CALCIUM CHANNELS; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; CHOLECALCIFEROL; INDICATORS AND REAGENTS; INTESTINES; MEMBRANE POTENTIALS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OSTEOBLASTS; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0031739625     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00164-3     Document Type: Article

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