Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D 3 analog QW-1624F 2-2: Calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry

Steroids

Volumn 69, Issue 11-12, 2004, Pages 757-762

  Posner, Gary H ^a   Jeon, Heung Bae ^a   Sarjeant, Amy ^a   Riccio, Edward S ^b   Doppalapudi, Rupa S ^b   Kapetanovic, Izet M ^c   Saha, Uttam ^d   Dolan, Patrick ^e   Kensler, Thomas W ^e  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b SRI INTERNATIONAL   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Cytochroma Inc   (Canada)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Calcitriol hybrid analog; Low calcemic analog

Indexed keywords

1ALPHA HYDROXYMETHYL 16 ENE 24,24 DIFLUORO 25 HYDROXY 26,27 BIS HOMOVITAMIN D3; CALCITRIOL; COLECALCIFEROL DERIVATIVE; QW 1624F2 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; GENOTOXICITY; MOUSE; NONHUMAN; STEREOCHEMISTRY; TOXICITY TESTING; X RAY CRYSTALLOGRAPHY;

ANIMALS; BONE MARROW CELLS; CALCITRIOL; CALCIUM; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MICE; MICRONUCLEUS TESTS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; RECEPTORS, CALCITRIOL; SALMONELLA; STEREOISOMERISM;

EID: 9644270392     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2004.09.004     Document Type: Article

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