Mechanism of action of superactive vitamin D analogs through regulated receptor degradation

Journal of Cellular Biochemistry

Volumn 76, Issue 4, 2000, Pages 548-558

  Jääskeläinen, Tiina ^a   Ryhänen, Sanna ^a   Mahonen, Anitta ^a   DeLuca, Hector F ^b   Mäenpää, Pekka H ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Analog; Calcitriol; Degradation; Proteasome; Vitamin D receptor

Indexed keywords

CALCITRIOL; LEXACALCITOL; SEOCALCITOL; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

ARTICLE; COMPLEX FORMATION; DNA BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; REGULATORY MECHANISM;

CALCITRIOL; CALCIUM CHANNEL AGONISTS; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; LEUPEPTINS; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; OSTEOBLASTS; OSTEOCALCIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RECEPTORS, CALCITRIOL; TUMOR CELLS, CULTURED; VITAMIN D;

EID: 0342632786     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000315)76:4<548::AID-JCB3>3.0.CO;2-0     Document Type: Article

References (40)

1. Baker AR, McDonnell DP, Hughes MR, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW. 1988. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA 85:3294-3298.
2. 3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol 42:1569-1575.
3. Bouillon R, Okamura WH, Norman AW. 1995. Structure-function relationships in the vitamin D endocrine system. Endocr Rev 16:200-257.
4. Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D. 1995. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375:377-382.
5. 3. Interplay with retinoid and thyroid hormone signalling. Eur J Biochem 231:517-527.
6. 3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol Cell Biol 14:3329-3338.
7. 3. Mol Endocrinol 9:1814-1824.
8. 3: Interactions with distinct receptor domains. Biochemistry 25:4523-4534.
9. 3 is due to reduced catabolism and altered protein binding. Biochem Pharmacol 47:987-993.
10. Dilworth FJ, Williams GR, Kissmeyer A-M, Løgsted-Nielsen J, Binderup E, Calverley MJ, Makin HLJ, Jones G. 1997. The vitamin D analog, KH 1060, is rapidly degraded both in vivo and in vitro via several pathways: Principle metabolites generated retain significant biological activity. Endocrinology 138:5485-5496.
11. El Khissiin A, Leclercq G. 1999. Implication of proteasome in estrogen receptor degradation. FEBS Lett 448:160-166.
12. Hurst HC, Masson N, Jones NC, Lee KAW. 1990. The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43. Mol Cell Biol 10:6192-6203.
13. 3 analogues and their 20-epi homologues with the vitamin D receptor. J Biol Chem 272:3336-3345.
14. Mahonen A, Jääskeläinen T, Mäenpää PH. 1996. A novel vitamin D analog with two double-bonds in its side chain. A potent inducer of osteoblastic cell differentiation. Biochem Pharmacol 51:887-892.
15. Masuyama H, MacDonald PN. 1998. Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR: J Cell Biochem 71:429-440.
16. Masuyama H, Brownfield CM, St-Arnaud R, MacDonald PN. 1997. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction. Mol Endocrinol 11:1507-1517.
17. Murakami Y, Matsufuji S, Kameji T, Hayashi S, Igarashi K, Tamura T, Tanaka K, Ichihara A. 1992. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature 360:597-599.
18. Nawaz Z, Lonard DM, Dennis AP, Smith CL, O'Malley BW. 1999. Proteasome-dependent degradation of the human estrogen receptor. Proc Natl Acad Sci USA 96:1858-1862.
19. 3 correlates well with gene activation. J Cell Biochem 62:325-333.
20. 3, a steroid hormone that produces biologic effects via both genomic and non-genomic pathways. J Steroid Biochem Molec Biol 41:231-240.
21. Parker MG, White R. 1996. Nuclear receptors spring into action. Nature Struct Biol 3:113-115.
22. 3 are associated with enhanced activation of the vitamin D receptor. J Biol Chem 270:10551-10558.
23. Pickart CM. 1997. Targeting of substrates to the 26S proteasome. FASEB J 11:1055-1066.
24. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP. 1999. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398:824-828.
25. Renaud J-P, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D. 1995. Crystal structure of the RAR-γ ligand binding domain bound to all-trans retinoic acid. Nature 378:681-689.
26. Ryhänen S, Mahonen A, Jääskeläinen T, Mäenpää PH. 1996. Synthetic 20-epi analogs of calcitriol are potent inducers of target-gene activation in osteoblastic cells. Eur J Biochem 238:97-103.
27. 3 analog with an extensively modified side chain (CB 1093). J Cell Biochem 70:414-424.
28. Syvälä H, Vienonen A, Zhuang Y-H, Kivineva M, Ylikomi T, Tuohimaa P. 1998. Evidence for enhanced ubiquitin-mediated proteolysis of the chicken progesterone receptor by progesterone. Life Sci 63:1505-1512.
29. Tanaka K. 1998. Molecular biology of the proteasome. Biochem Biophys Res Commun 247:537-541.
30. 3 receptor anti-peptide antibodies. J Steroid Biochem Mol Biol 43:649-657.
31. Väisänen S, Juntunen K, Itkonen A, Vihko P, Mäenpää PH. 1997. Conformational studies of human vitamin-D receptor by antipeptide antibodies, partial proteolytic digestion and ligand binding. Eur J Biochem 248:156-162.
32. 3 receptor are important for the binding of calcitriol. FEBS Lett 440:203-207.
33. 3 analogs. Eur J Biochem 261:706-713.
34. 3 analogs on osteoblast-like cells and on in vitro bone resorption. J Steroid Biochem Mol Biol 55:337-346.
35. 3 analog KH1060. Proc Natl Acad Sci USA 93:10685-10690.
36. vom Baur E, Zechel C, Heery D, Heine MJS, Gamier JM, Vivat V, Le Douarin B, Gronemeyer H, Chambon P, Losson R. 1996. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J 15:110-124.
37. Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ. 1995. A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697.
38. 3 results from ligand-induced stabilization. J Biol Chem 267:20082-20086.
39. Wurtz J-M, Bourguet W, Renaud J-P, Vivat V, Chambon P, Moras D, Gronemeyer H. 1996. A canonical structure for the ligand-binding domain of the nuclear receptors. Nature Struct Biol 3:87-94.
40. 3 receptor. J Biol Chem 274:16838-16845.