Engineering the catalytic domain of human protein tyrosine phosphatase β for structure-based drug discovery

Acta Crystallographica Section D: Biological Crystallography

Volumn 62, Issue 12, 2006, Pages 1435-1445

  Evdokimov, Artem G ^a   Pokross, Matthew ^a   Walter, Richard ^b   Mekel, Marlene ^a   Cox, Brooke ^a   Li, Chuiying ^a   Bechard, Randy ^a   Genbauffe, Frank ^a   Andrews, Ryan ^a   Diven, Conrad ^a   Howard, Brian ^a   Rastogi, Vinit ^a   Gray, Jeffrey ^a   Maier, Matthew ^a   Peters, Kevin G ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Protein tyrosine phosphatase ; Structure based drug discovery

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845479013     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444906037784     Document Type: Article

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