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Volumn 291, Issue 6, 2006, Pages

PPARα activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans

Author keywords

Dexamethasone; Insulin sensitivity; Metabolic syndrome; Peroxisome proliferator activated receptor

Indexed keywords

CHOLESTEROL; DEXAMETHASONE; FENOFIBRATE; GLUCOCORTICOID; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; ANTILIPEMIC AGENT;

EID: 33845462872     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00230.2006     Document Type: Article
Times cited : (31)

References (36)
  • 1
    • 0037407403 scopus 로고    scopus 로고
    • NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
    • Alexander CM, Landsman PB, Teutsch SM, and Haffner SM. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 52: 1210-1214, 2003.
    • (2003) Diabetes , vol.52 , pp. 1210-1214
    • Alexander, C.M.1    Landsman, P.B.2    Teutsch, S.M.3    Haffner, S.M.4
  • 3
    • 14844292088 scopus 로고    scopus 로고
    • Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: Results from the Diabetes Atherosclerosis Intervention Study (DAIS)
    • Ansquer JC, Foucher C, Rattier S, Taskinen MR, and Steiner G. Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: results from the Diabetes Atherosclerosis Intervention Study (DAIS). Am J Kidney Dis 45: 485-493, 2005.
    • (2005) Am J Kidney Dis , vol.45 , pp. 485-493
    • Ansquer, J.C.1    Foucher, C.2    Rattier, S.3    Taskinen, M.R.4    Steiner, G.5
  • 7
    • 0037025390 scopus 로고    scopus 로고
    • WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice
    • Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, and Reitman ML. WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J Biol Chem 277: 24484-24489, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 24484-24489
    • Chou, C.J.1    Haluzik, M.2    Gregory, C.3    Dietz, K.R.4    Vinson, C.5    Gavrilova, O.6    Reitman, M.L.7
  • 8
    • 33645509709 scopus 로고    scopus 로고
    • Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing fatty acid oxidation
    • Du X, Edelstein D, Obici S, Higham N, Zou MH, and Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing fatty acid oxidation. J Clin Invest 116: 1071-1080.
    • J Clin Invest , vol.116 , pp. 1071-1080
    • Du, X.1    Edelstein, D.2    Obici, S.3    Higham, N.4    Zou, M.H.5    Brownlee, M.6
  • 10
    • 0029945403 scopus 로고    scopus 로고
    • Gemfibrozil treatment of endogenous hypertriglyceridemia: Effect on insulin-mediated glucose disposal and plasma insulin concentrations
    • Jeng CY, Sheu WH, Fuh MM, Shieh SM, Chen YD, and Reaven GM. Gemfibrozil treatment of endogenous hypertriglyceridemia: effect on insulin-mediated glucose disposal and plasma insulin concentrations. J Clin Endocrinol Metab 81: 2550-2553, 1996.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2550-2553
    • Jeng, C.Y.1    Sheu, W.H.2    Fuh, M.M.3    Shieh, S.M.4    Chen, Y.D.5    Reaven, G.M.6
  • 11
    • 24144484876 scopus 로고    scopus 로고
    • The metabolic syndrome: Time for a critical appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Kahn R, Buse J, Ferrannini E, and Stern M. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28: 2289-2304, 2005.
    • (2005) Diabetes Care , vol.28 , pp. 2289-2304
    • Kahn, R.1    Buse, J.2    Ferrannini, E.3    Stern, M.4
  • 15
    • 0035943681 scopus 로고    scopus 로고
    • Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression
    • Lawrence JW, Li Y, Chen S, DeLuca JG, Berger JP, Umbenhauer DR, Moller DE, and Zhou G. Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression. J Biol Chem 276: 31521-31527, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 31521-31527
    • Lawrence, J.W.1    Li, Y.2    Chen, S.3    DeLuca, J.G.4    Berger, J.P.5    Umbenhauer, D.R.6    Moller, D.E.7    Zhou, G.8
  • 16
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors α and β are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, and Kliewer SA. Peroxisome proliferator-activated receptors α and β are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272: 3406-3410.
    • J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 17
    • 0037079309 scopus 로고    scopus 로고
    • Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies
    • Lewington S, Clarke R, Qizilbash N, Peto R, and Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360: 1903-1913, 2002.
    • (2002) Lancet , vol.360 , pp. 1903-1913
    • Lewington, S.1    Clarke, R.2    Qizilbash, N.3    Peto, R.4    Collins, R.5
  • 18
    • 0037068623 scopus 로고    scopus 로고
    • Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes
    • Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, and Batlle D. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med 347: 797-805, 2002.
    • (2002) N Engl J Med , vol.347 , pp. 797-805
    • Lurbe, E.1    Redon, J.2    Kesani, A.3    Pascual, J.M.4    Tacons, J.5    Alvarez, V.6    Batlle, D.7
  • 21
    • 0018838168 scopus 로고
    • Cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: Mortality follow-up. Report of the Committee of Principal Investigators
    • Oliver MF, Heady JA, Morris JN, and Cooper JWHO. cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report of the Committee of Principal Investigators. Lancet 316: 379-385, 1980.
    • (1980) Lancet , vol.316 , pp. 379-385
    • Oliver, M.F.1    Heady, J.A.2    Morris, J.N.3    Cooper, J.W.H.O.4
  • 22
    • 84920245150 scopus 로고
    • Cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: Final mortality follow-up. Report of the Committee of Principal Investigators
    • Oliver MF, Heady JA, Morris JN, and Cooper JWHO. Cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the Committee of Principal Investigators. Lancet 324: 600-604, 1984.
    • (1984) Lancet , vol.324 , pp. 600-604
    • Oliver, M.F.1    Heady, J.A.2    Morris, J.N.3    Cooper, J.W.H.O.4
  • 24
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
    • Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB, Faas FH, Linares E, Schaefer EJ, Schectman G, Wilt TJ, and Wittes J. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 341: 410-418, 1999.
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 25
    • 0026075385 scopus 로고
    • Effect of gemfibrozil treatment in sulfonylurea-treated patients with noninsulin-dependent diabetes mellitus
    • Shen DC, Fuh MM, Shieh SM, Chen YD, and Reaven GM. Effect of gemfibrozil treatment in sulfonylurea-treated patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 73: 503-510, 1991.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 503-510
    • Shen, D.C.1    Fuh, M.M.2    Shieh, S.M.3    Chen, Y.D.4    Reaven, G.M.5
  • 26
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B and Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 54: 2460-2470, 2005.
    • (2005) Diabetes , vol.54 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 29
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study
    • The BIP Study Group
    • The BIP Study Group. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 102: 21-27, 2000.
    • (2000) Circulation , vol.102 , pp. 21-27
  • 33
    • 0036259045 scopus 로고    scopus 로고
    • Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia
    • Whitelaw DC, Smith JM, and Nattrass M. Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia. Diabetes Obes Metab 4: 187-194, 2002.
    • (2002) Diabetes Obes Metab , vol.4 , pp. 187-194
    • Whitelaw, D.C.1    Smith, J.M.2    Nattrass, M.3
  • 34
    • 0033695157 scopus 로고    scopus 로고
    • Cushing, cortisol, and cardiovascular disease
    • Whitworth JA, Mangos GJ, and Kelly JJ. Cushing, cortisol, and cardiovascular disease. Hypertension 36: 912-916, 2000.
    • (2000) Hypertension , vol.36 , pp. 912-916
    • Whitworth, J.A.1    Mangos, G.J.2    Kelly, J.J.3
  • 35
    • 0035675355 scopus 로고    scopus 로고
    • Venous occlusion plethysmography in cardiovascular research: Methodology and clinical applications
    • Wilkinson IB and Webb DJ. Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications. Br J Clin Pharmacol 52: 631-646, 2001.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 631-646
    • Wilkinson, I.B.1    Webb, D.J.2
  • 36
    • 0033377677 scopus 로고    scopus 로고
    • The effect of fenofibrate on insulin sensitivity and plasma lipid profile in non-diabetic males with low high density lipoprotein/dyslipidaemic syndrome
    • Yong QW, Thavintharan S, Cheng A, and Chew LS. The effect of fenofibrate on insulin sensitivity and plasma lipid profile in non-diabetic males with low high density lipoprotein/dyslipidaemic syndrome. Ann Acad Med Singapore 28: 778-782, 1999.
    • (1999) Ann Acad Med Singapore , vol.28 , pp. 778-782
    • Yong, Q.W.1    Thavintharan, S.2    Cheng, A.3    Chew, L.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.