Gemfibrozil improves insulin sensitivity and flow-mediated vasodilatation in type 2 diabetic patients

European Journal of Clinical Investigation

Volumn 31, Issue 7, 2001, Pages 603-609

  Avogaro, A ^a   Miola, M ^a   Favaro, A ^a   Gottardo, L ^a   Pacini, G ^b   Manzato, E ^a   Zambon, S ^a   Sacerdoti, D ^a   De Kreutzenberg, S ^a   Piliego, T ^c   Tiengo, A ^a   Del Prato, S ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Istituto di Ingeneria Biomedica del CNR   (Italy)

^c University of Padova ^*  (Italy)

Author keywords

Diabetes mellitus; Endothelium; Insulin action; Lipoproteins; Triglycerides

Indexed keywords

GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERMEDIATE DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

ARTERY BLOOD FLOW; ARTICLE; BRACHIAL ARTERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ECHOGRAPHY; HUMAN; INSULIN SENSITIVITY; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION;

AGED; ANTILIPEMIC AGENTS; ARTERIOSCLEROSIS; BLOOD CIRCULATION; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; GEMFIBROZIL; HUMANS; HYPERTRIGLYCERIDEMIA; INSULIN; INSULIN RESISTANCE; TRIGLYCERIDES; VASODILATION;

EID: 0034945479     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2001.00856.x     Document Type: Article

References (33)

1. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells
2. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
3. Defective nitric oxide synthesis, a link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity
4. Hemodynamic actions of insulin
5. Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus
6. Endothelial dysfunction in a model of hyperglycemia and hyperinsulinemia
7. Coronary risk factors, endothelial function, and atherosclerosis: A review
8. Endothelium-dependent relaxation by acetylcholine is impaired in hypertriglyceridemic humans with normal levels of plasma LDL cholesterol
9. Effect of a single high-fat meal On endothelial function in healthy subjects
10. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal
11. Impaired brachial artery endothelial function is not predicted by elevated triglycerides
12. Determination of free and total insulin and C-peptide in insulin- treated diabetics
13. Plasma concentrations of high-density lipoprotein (HDL)-2 and HDL-3 in myocardial infarction survivors and in control subjects
14. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach
15. Minmod: A computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test
16. Preparative and quantitative isolation of plasma lipoproteins: Rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor
17. Lipoprotein abnormalities in non-insulin-dependent diabetic patients with impaired extrahepatic insulin sensitivity, hypertension, and microalbuminuria
18. Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease
19. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries
20. Vascular reactivity
21. Preserved endothelial function in patients with severe hypertriglyceridemia and low functional lipoprotein lipase activity
22. Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus
23. Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients
24. Insulin-induced vasodilatation: Physiology or pharmacology?
25. Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non- insulin-dependent diabetes mellitus
26. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
27. The pathogenesis of vascular complications of diabetes mellitus: One voice or many?
28. Gemfibrozil treatment increases low-density lipoprotein particle size in type 2 diabetes mellitus but does not alter in vitro oxidizability
29. Effects of gemfibrozil on very-low-density lipoprotein composition and low-density lipoprotein size in patients with hypertriglyceridemia or combined hyperlipidemia
30. Effects of gemfibrozil on low-density lipoprotein particle size, density distribution, and composition in patients with type II diabetes
31. Lipoprotein modification: Cellular mechanisms
32. Disruption of endothelial barrier function by lipolytic remnants of triglyceride-rich lipoproteins
33. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus