Glucocorticoid metabolism and the metabolic syndrome: Associations in an elderly cohort

Experimental and Clinical Endocrinology and Diabetes

Volumn 110, Issue 6, 2002, Pages 284-290

  Andrew, R ^a   Gale, C R ^a   Walker, B R ^a   Seckl, J R ^a   Martyn, C N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cortisol; Metabolic Syndrome; Metabolism; Obesity

Indexed keywords

CORTISONE; GLUCOCORTICOID; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

AGED; ARTICLE; BLOOD PRESSURE; BODY MASS; COHORT ANALYSIS; FEMALE; GAS CHROMATOGRAPHY; GERIATRIC PATIENT; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLIC SYNDROME X; OBESITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; BIOSYNTHESIS; CHILD; INFANT; METABOLISM; PATHOPHYSIOLOGY; PRESCHOOL CHILD;

AGED; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GLUCOCORTICOIDS; HUMANS; HYPERTENSION; INFANT; MALE; METABOLIC SYNDROME X; OBESITY;

EID: 0036710815     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-34591     Document Type: Article

References (36)

1. Andrew R, Phillips DIW, Walker BR. Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 1998; 83: 1806-1809
2. Andrews RC, Andrew R, Herlihy O, Walker BR. Abnormal glucocorticoid metabolism and sensitivity in type 2 diabetes mellitus. J Endocrinol 1999; 163: P28
3. Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): Relation to reduced fetal growth. Diabetologia 1993: 36: 62-67
4. Best R, Walker BR. Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11β-hydroxysteroid dehydrogenase in vivo. Clin Endocrinol (Oxf) 1997; 47: 231-236
5. Clark PM, Hindmarsh PC, Shiell AW, Law CM, Honour JW, Barker DJP. Size at birth and adrenocortical function in childhood. Clin Endocrinol (Oxf) 1996; 45: 721-726
6. Filipovsky J, Ducimetiere P, Eschwege E, Richard JL, Rosselin G, Claude JR. The relationship of blood pressure with glucose, insulin, heart rate, free fatty acids and plasma cortisol levels according to degree of obesity in middle-aged men. J Hypertens 1996; 14: 229-235
7. Finken MJJ, Andrews RC, Andrew R, Walker BR. Cortisol metabolism in healthy young adults: Sexual dimorphism in activities of A-ring reductase but not 11-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab 1999; 84: 3316-3321
8. Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JMC. Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 1999; 33: 1364-1368
9. Hautanen A, Adlercreutz H. Altered adrenocorticotropin and cortisol secretion in abdominal obesity: Implications for the insulin resistance syndrome. J Intern Med 1993; 234: 461-469
10. Horton R, Pasupuletti V, Antonipillai I. Androgen induction of steroid 5α-reductase may be mediated via insulin-like growth factor-1. Endocrinology 1993; 133: 447-451
11. Jamieson A, Wallace AM, Walker BR, Andrew R, Fraser R, White PC, Connell JMC. Apparent cortisone reductase deficiency: A defect in 11β-hydroxysteroid dehydrogenase type 1 or in cortisone 5β-reductase? J Clin Endocrinol Metab 1999; 84: 3570-3574
12. Kerstens MN, Sluiter WJ, Pratt JJ, Wolthers BG, Dullaart RBF. Lack of relationship between 11-betahydroxysteroiddehydrogenase setpoint and insulin sensitivity in the basal state and after 24 h of insulin infusion in healthy subjects and type 2 diabetic patients. Clin Endocrinol (Oxf) 2000; 52: 403-411
13. Kotelevtsev YV, Holmes MC, Burchell A, Houston PM, Scholl D, Jamieson PM, Best R, Brown RW, Edwards CRW, Seckl JR, Mullins JJ. 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid inducible responses and resist hyperglycaemia on obesity and stress. PNAS 1997; 94: 14924-14929
14. Levitt NS, Lambert EV, Woods D, Hales CN, Andrew R, Seckl JR. Impaired glucose tolerance and elevated blood pressure in low birthwieght, non-obese, young South African adults: Early programming of the cortisol axis. J Clin Endocrino Metab 2000; 85: 4611-4618
15. Ljung T, Andersson B, Bengtsson B, Bjorntorp P, Marin P. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: A dose-response study. Obesity Research 1996; 4: 277-282
16. Lottenberg SA, Giannella-Neto D, Derendorf H, Rocha M, Bosco A, Carvalho SV, Moretti AE, Lerario AC, Wajchenberg BL. Effect of fat distribution on the pharmacokinetics of cortisol in obesity. International Journal of Clinical Pharmacology and Therapeutics 1998; 36: 501-505
17. Masuzaki H, Paterson J, Shinyama H, Morton N, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and the Metabolic Syndrome. Science 2001; 294: 2166-2170
18. Marin P, Darin M, Amemiya T, Andersson B, Jern S, Bjorntorp P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992; 41: 882-886
19. Martyn CN, Gale CR, Jespersen S, Sherriff SB. Impaired fetal growth and atherosclerosis of carotid and peripheral arteries. Lancet 1998; 352: 173-178
20. Miller MA, Colas AE. Multihormanol control of microsomal 5-αreductase activity in cultured adult female rat hepatocytes. Endocrinology 1982; 111: 136-143
21. Nyirenda MJ, Lindsay RS, Kenyon CJ, Burchell A, Seckl JR. Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 1998; 101: 2174-2181
22. Phillips DIW, Barker DJP, Fall CHD, Whorwood CB, Seckl JR, Wood PJ, Walker BR. Elevated plasma cortisol concentrations: An explanation for the relationship between low birthweight and adult cardiovascular risk factors. J Clin Endocrinol Metab 1998; 83: 757-760
23. Phillips DIW, Walker BR, Reynolds RM, Flanagan DEH, Wood PJ, Osmond C, Barker DJ, Whorwood CB. Low birthweight predicts elevated plasma cortisol concentrations in adults from three populations. J Intern Med 35 (6) 2000; 1301-1306
24. Rask E, Olsson T, Soderberg S, Andrew R, Livingstone DEW, Johnson O, Walker BR. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 2001; 86: 1418-1421
25. Raven PW, Taylor NF. Sex differences in the human metabolism of cortisol. Endocrine Research 1996; 22: 751-755
26. Reynolds RM, Walker BR, Sydall HE, Andrew R, Wood PJ, Whorwood CB, Phillips DIW. Altered control of cortisol secretion in adult men with low birthweight and cardiovascular risk factors. J Clin Endocrinol Metab 2001; 86: 245-250
27. Rosmond R, Dallman MF, Bjorntorp P. Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and haemodynamic abnormalities. J Clin Endocrinol Metab 1998; 83: 1853-1859
28. Soro A, Ingram MC, Tonolo G, Glorioso N, Fraser R. Evidence of coexisting changes in 11β-hydroxysteroid dehydrogenase and 5β-reductase activity in patients with untreated essential hypertension. Hypertension 1995; 25: 67-70
29. Stewart PM, Boulton A, Kumar S, Clark PMS, Shackleton CHL. Cortisol metabolism in human obesity: Impaired cortisone - Cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999; 84: 1022-1027
30. Strain GW, Zumoff B, Kream J, Strain JJ, Levin J, Fukushima D. Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol. Metabolism 1982; 31: 209-212
31. Ulick S, Levine LS, Gunczler P, Zanconato G, Ramirez LC, Rauh W, Rosler A, Bradlow HL, New MI. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 1979; 49: 757-764
32. Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CRW. Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 1995; 80: 3155-3159
33. Walker BR, Phillips DIW, Noon JP, Panarelli M, Best R, Edwards HE, Holton DW, Seckl JR, Webb DJ, Watt GCM. Increased glucocorticoid activity in men with cardiovascular risk factors. Hypertension 1998; 31: 891-895
34. Walker BR, Soderberg S, Lindahl B, Olsson T. Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women. J Intern Med 2000; 247: 198-204
35. Walker BR, Stewart PM, Shackleton CHL, Padfield PL, Edwards CRW. Deficient inactivation of cortisol by 11β-hydroxysteroid dehydrogenase in essential hypertension. Clin Endocrinol (Oxf) 1993; 39: 221-227
36. Watt GCM, Harrap SB, Foy CJW, Holton DW, Edwards HV, Davidson HR, Connor JM, Lever AF, Fraser R. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: A four corners approach to the identification of genetic determinants of blood pressure. J Hypertens 1992; 10: 473-482