-
2
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., and Hall M.N. TOR, a central controller of cell growth. Cell 103 (2000) 253-262
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
3
-
-
0035971180
-
The TOR kinases link nutrient sensing to cell growth
-
Rohde J., Heitman J., and Cardenas M.E. The TOR kinases link nutrient sensing to cell growth. J. Biol. Chem. 276 (2001) 9583-9586
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9583-9586
-
-
Rohde, J.1
Heitman, J.2
Cardenas, M.E.3
-
4
-
-
0042197413
-
Mammalian target of rapamycin: a new molecular target for breast cancer
-
Mita M.M., Mita A., and Rowinsky E.K. Mammalian target of rapamycin: a new molecular target for breast cancer. Clin. Breast Cancer 4 (2003) 126-137
-
(2003)
Clin. Breast Cancer
, vol.4
, pp. 126-137
-
-
Mita, M.M.1
Mita, A.2
Rowinsky, E.K.3
-
5
-
-
1142277821
-
Akt2 expression correlates with prognosis of human hepatocellular carcinoma
-
Xu X., Sakon M., Nagano H., Hiraoka N., Yamamoto H., Hayashi N., Dono K., Nakamori S., Umeshita K., Ito Y., Matsuura N., and Monden M. Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol. Rep. 11 (2004) 25-32
-
(2004)
Oncol. Rep.
, vol.11
, pp. 25-32
-
-
Xu, X.1
Sakon, M.2
Nagano, H.3
Hiraoka, N.4
Yamamoto, H.5
Hayashi, N.6
Dono, K.7
Nakamori, S.8
Umeshita, K.9
Ito, Y.10
Matsuura, N.11
Monden, M.12
-
6
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
-
Isotani S., Hara K., Tokunaga C., Inoue H., Avruch J., and Yonezawa K. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J. Biol. Chem. 274 (1999) 34493-34498
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
7
-
-
0030716488
-
Regulation of eIF-4E BP1 phosphorylation by mTOR
-
Hara K., Yonezawa K., Kozlowski M.T., Sugimoto T., Andrabi K., Weng Q.P., Kasuga M., Nishimoto I., and Avruch J. Regulation of eIF-4E BP1 phosphorylation by mTOR. J. Biol. Chem. 272 (1997) 26457-26463
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 26457-26463
-
-
Hara, K.1
Yonezawa, K.2
Kozlowski, M.T.3
Sugimoto, T.4
Andrabi, K.5
Weng, Q.P.6
Kasuga, M.7
Nishimoto, I.8
Avruch, J.9
-
8
-
-
0030915898
-
Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
-
Jefferies H.B., Fumagalli S., Dennis P.B., Reinhard C., Pearson R.B., and Thomas G. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J. 16 (1997) 3693-3704
-
(1997)
EMBO J.
, vol.16
, pp. 3693-3704
-
-
Jefferies, H.B.1
Fumagalli, S.2
Dennis, P.B.3
Reinhard, C.4
Pearson, R.B.5
Thomas, G.6
-
9
-
-
1542365129
-
Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner
-
Wu X., Reiter C.E., Antonetti D.A., Kimball S.R., Jefferson L.S., and Gardner T.W. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. J. Biol. Chem. 279 (2004) 9167-9175
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9167-9175
-
-
Wu, X.1
Reiter, C.E.2
Antonetti, D.A.3
Kimball, S.R.4
Jefferson, L.S.5
Gardner, T.W.6
-
10
-
-
0016713286
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal S.N., Baker H., and Vezina C. Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot. 28 (1975) 727-732
-
(1975)
J. Antibiot.
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
11
-
-
18144399578
-
mTOR-targeted therapy of cancer with rapamycin derivatives
-
Vignot S., Faivre S., Aguirre D., and Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann. Oncol. 16 (2005) 525-537
-
(2005)
Ann. Oncol.
, vol.16
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
Raymond, E.4
-
12
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E., Alexandre J., Faivre S., Vera K., Materman E., Boni J., Leister C., Korth-Bradley J., Hanauske A., and Armand J.P. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J. Clin. Oncol. 22 (2004) 2336-2347
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
Leister, C.7
Korth-Bradley, J.8
Hanauske, A.9
Armand, J.P.10
-
13
-
-
0034790016
-
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K., Toral-Barza L., Discafani C., Zhang W.G., Skotnicki J., Frost P., and Gibbons J.J. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr. Relat. Cancer 8 (2001) 249-258
-
(2001)
Endocr. Relat. Cancer
, vol.8
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
Zhang, W.G.4
Skotnicki, J.5
Frost, P.6
Gibbons, J.J.7
-
14
-
-
0024473604
-
G1 events and regulation of cell proliferation
-
Pardee A.B. G1 events and regulation of cell proliferation. Science 246 (1989) 603-608
-
(1989)
Science
, vol.246
, pp. 603-608
-
-
Pardee, A.B.1
-
15
-
-
1542358171
-
Modulation of insulin effects on phosphorylation of protein kinase B and glycogen synthesis by tumor necrosis factor-alpha in HepG2 cells
-
Gupta D., and Khandelwal R.L. Modulation of insulin effects on phosphorylation of protein kinase B and glycogen synthesis by tumor necrosis factor-alpha in HepG2 cells. Biochim. Biophys. Acta 1671 (2004) 51-58
-
(2004)
Biochim. Biophys. Acta
, vol.1671
, pp. 51-58
-
-
Gupta, D.1
Khandelwal, R.L.2
-
16
-
-
0033802721
-
Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells
-
Syed N.A., and Khandelwal R.L. Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells. Mol. Cell. Biochem. 211 (2000) 123-136
-
(2000)
Mol. Cell. Biochem.
, vol.211
, pp. 123-136
-
-
Syed, N.A.1
Khandelwal, R.L.2
-
17
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik G., Klippel A., and Weber M.J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17 (1997) 1595-1606
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
18
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H., Datta S.R., Franke T.F., Birnbaum M.J., Yao R., Cooper G.M., Segal R.A., Kaplan D.R., and Greenberg M.E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275 (1997) 661-665
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
19
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh A., Rodriguez-Viciana P., Ulrich E., Gilbert C., Coffer P., Downward J., and Evan G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385 (1997) 544-548
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
20
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
-
Khamzina L., Veilleux A., Bergeron S., and Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146 (2005) 1473-1481
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
21
-
-
3242721268
-
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K., and Yamanaka S. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol. Cell. Biol. 24 (2004) 6710-6718
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
22
-
-
0029794614
-
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
-
Seufferlein T., and Rozengurt E. Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells. Cancer Res. 56 (1996) 3895-3897
-
(1996)
Cancer Res.
, vol.56
, pp. 3895-3897
-
-
Seufferlein, T.1
Rozengurt, E.2
-
23
-
-
0026739991
-
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979
-
Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979. Biotechnology 24 (1992) 145-149
-
(1992)
Biotechnology
, vol.24
, pp. 145-149
-
-
Towbin, H.1
Staehelin, T.2
Gordon, J.3
-
25
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
26
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: application to proliferative and cytotoxicity assays
-
Mossman T. Rapid colorimetric assay for cellular growth and survival: application to proliferative and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mossman, T.1
-
27
-
-
0017184389
-
A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M.M. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
28
-
-
16644393866
-
Effect of overexpression and nuclear translocation of constitutively active PKB-alpha on cellular survival and proliferation in HepG2 cells
-
Gupta D., Syed N.A., Roesler W.J., and Khandelwal R.L. Effect of overexpression and nuclear translocation of constitutively active PKB-alpha on cellular survival and proliferation in HepG2 cells. J. Cell. Biochem. 93 (2004) 513-525
-
(2004)
J. Cell. Biochem.
, vol.93
, pp. 513-525
-
-
Gupta, D.1
Syed, N.A.2
Roesler, W.J.3
Khandelwal, R.L.4
-
29
-
-
0032560521
-
Jr., Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
-
Scott P.H., Brunn G.J., Kohn A.D., Roth R.A., and Lawrence J.C. Jr., Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. 95 (1998) 7772-7777
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 7772-7777
-
-
Scott, P.H.1
Brunn, G.J.2
Kohn, A.D.3
Roth, R.A.4
Lawrence, J.C.5
-
30
-
-
18844390423
-
Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino acids
-
Shen W.H., Boyle D.W., Wisniowski P., Bade A., and Liechty E.A. Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino acids. J. Endocrinol. 185 (2005) 275-289
-
(2005)
J. Endocrinol.
, vol.185
, pp. 275-289
-
-
Shen, W.H.1
Boyle, D.W.2
Wisniowski, P.3
Bade, A.4
Liechty, E.A.5
-
31
-
-
0028178928
-
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
-
Chung J., Grammer T.C., Lemon K.P., Kazlauskas A., and Blenis J. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370 (1994) 71-75
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
Kazlauskas, A.4
Blenis, J.5
-
32
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah O.J., Wang Z., and Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14 (2004) 1650-1656
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
33
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., and Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431 (2004) 200-205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
34
-
-
0033557578
-
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
-
Hosoi H., Dilling M.B., Shikata T., Liu L.N., Shu L., Ashmun R.A., Germain G.S., Abraham R.T., and Houghton P.J. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 59 (1999) 886-894
-
(1999)
Cancer Res.
, vol.59
, pp. 886-894
-
-
Hosoi, H.1
Dilling, M.B.2
Shikata, T.3
Liu, L.N.4
Shu, L.5
Ashmun, R.A.6
Germain, G.S.7
Abraham, R.T.8
Houghton, P.J.9
-
35
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
|