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Volumn 62, Issue 3, 2007, Pages 756-765

Solids motion in a conical frustum-shaped high shear mixer granulator

Author keywords

Granulation; High shear granulator; Mixing; PEPT; Solids motion

Indexed keywords

FLOW PATTERNS; GRANULATION; IMPELLERS; MIXING; SWIRLING FLOW;

EID: 33845413710     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2006.10.003     Document Type: Article
Times cited : (19)

References (71)
  • 1
    • 0027790597 scopus 로고
    • The effect of process parameters on drum granulation of fertilizers with broad size distributions
    • Adetayo A.A., Litster J.D., and Desai M. The effect of process parameters on drum granulation of fertilizers with broad size distributions. Chemical Engineering Science 48 23 (1993) 3951-3961
    • (1993) Chemical Engineering Science , vol.48 , Issue.23 , pp. 3951-3961
    • Adetayo, A.A.1    Litster, J.D.2    Desai, M.3
  • 3
    • 2342456453 scopus 로고    scopus 로고
    • On control of particle size distribution in granulation using high-shear mixers
    • Bardin M., Knight P.C., and Seville J.P.K. On control of particle size distribution in granulation using high-shear mixers. Powder Technology 140 (2004) 169-175
    • (2004) Powder Technology , vol.140 , pp. 169-175
    • Bardin, M.1    Knight, P.C.2    Seville, J.P.K.3
  • 4
    • 0028273201 scopus 로고
    • Scale-up of a spray dry tablet granulation process: thermodynamic considerations
    • Berman J., Pierce P., and Page P. Scale-up of a spray dry tablet granulation process: thermodynamic considerations. Drug Development and Industrial Pharmacy 20 5 (1994) 731-755
    • (1994) Drug Development and Industrial Pharmacy , vol.20 , Issue.5 , pp. 731-755
    • Berman, J.1    Pierce, P.2    Page, P.3
  • 5
    • 0037452439 scopus 로고    scopus 로고
    • Power consumption profile analysis and tensile strength measurements during moist agglomeration
    • Betz G., Burgin P.J., and Leuenberger H. Power consumption profile analysis and tensile strength measurements during moist agglomeration. International Journal of Pharmaceutics 252 1-2 (2003) 11-25
    • (2003) International Journal of Pharmaceutics , vol.252 , Issue.1-2 , pp. 11-25
    • Betz, G.1    Burgin, P.J.2    Leuenberger, H.3
  • 6
    • 1442299815 scopus 로고    scopus 로고
    • Power consumption measurement and temperature recording during granulation
    • Betz G., Burgin P.J., and Leuenberger H. Power consumption measurement and temperature recording during granulation. International Journal of Pharmaceutics 272 1-2 (2004) 137-149
    • (2004) International Journal of Pharmaceutics , vol.272 , Issue.1-2 , pp. 137-149
    • Betz, G.1    Burgin, P.J.2    Leuenberger, H.3
  • 7
    • 0021787404 scopus 로고
    • The batch granulation process in a fluidized bed
    • Bin A., Warych J., and Komorowski R. The batch granulation process in a fluidized bed. Powder Technology 41 1 (1985) 1-10
    • (1985) Powder Technology , vol.41 , Issue.1 , pp. 1-10
    • Bin, A.1    Warych, J.2    Komorowski, R.3
  • 8
    • 12344262844 scopus 로고    scopus 로고
    • The effect of the amount of binder liquid on the granulation mechanisms and structure of microcrystalline cellulose granules prepared by high shear granulation
    • Bouwman A.M., Henstra M.J., Westerman D., Chung J.T., Zhang Z., Ingram A., Seville J.P.K., and Frijlink H.W. The effect of the amount of binder liquid on the granulation mechanisms and structure of microcrystalline cellulose granules prepared by high shear granulation. International Journal of Pharmaceutics 290 1-2 (2005) 129-136
    • (2005) International Journal of Pharmaceutics , vol.290 , Issue.1-2 , pp. 129-136
    • Bouwman, A.M.1    Henstra, M.J.2    Westerman, D.3    Chung, J.T.4    Zhang, Z.5    Ingram, A.6    Seville, J.P.K.7    Frijlink, H.W.8
  • 11
    • 0033553872 scopus 로고    scopus 로고
    • Melt granulation in a high shear mixer: optimization of mixture and process variables using a combined experimental design
    • Campisi B., Vojnovic D., Chicco D., and Phan-Tan-Luu R. Melt granulation in a high shear mixer: optimization of mixture and process variables using a combined experimental design. Chemometrics and Intelligent Laboratory Systems 48 1 (1999) 59-70
    • (1999) Chemometrics and Intelligent Laboratory Systems , vol.48 , Issue.1 , pp. 59-70
    • Campisi, B.1    Vojnovic, D.2    Chicco, D.3    Phan-Tan-Luu, R.4
  • 13
    • 33845407948 scopus 로고    scopus 로고
    • Particle size control by torque measurements in fluidized bed during drying and granulation from solutions
    • Dencs B., Gyenis J., and Tardos G.I. Particle size control by torque measurements in fluidized bed during drying and granulation from solutions. Bulgarian Chemical Communications 33 3-4 (2001) 320-330
    • (2001) Bulgarian Chemical Communications , vol.33 , Issue.3-4 , pp. 320-330
    • Dencs, B.1    Gyenis, J.2    Tardos, G.I.3
  • 14
    • 0025539875 scopus 로고
    • The influence of viscosity on the strength of an axially strained pendular liquid bridge
    • Ennis B.J., Li J., Tardos G.I., and Pfeffer R. The influence of viscosity on the strength of an axially strained pendular liquid bridge. Chemical Engineering Science 45 10 (1990) 3071-3088
    • (1990) Chemical Engineering Science , vol.45 , Issue.10 , pp. 3071-3088
    • Ennis, B.J.1    Li, J.2    Tardos, G.I.3    Pfeffer, R.4
  • 15
    • 0026117532 scopus 로고
    • A microlevel-based characterization of granulation phenomena
    • Ennis B.J., Tardos G., and Pfeffer R. A microlevel-based characterization of granulation phenomena. Powder Technology 65 1-2 (1991) 257-272
    • (1991) Powder Technology , vol.65 , Issue.1-2 , pp. 257-272
    • Ennis, B.J.1    Tardos, G.2    Pfeffer, R.3
  • 16
    • 4043097204 scopus 로고    scopus 로고
    • Influence of nature and particle size distribution on granulation of iron ore mixtures used in a sinter strand
    • Formoso A., Moro A., Pello G.F., Menendez J.L., Muniz M., and Cores A. Influence of nature and particle size distribution on granulation of iron ore mixtures used in a sinter strand. Ironmaking and Steelmaking 30 6 (2003) 447-460
    • (2003) Ironmaking and Steelmaking , vol.30 , Issue.6 , pp. 447-460
    • Formoso, A.1    Moro, A.2    Pello, G.F.3    Menendez, J.L.4    Muniz, M.5    Cores, A.6
  • 17
    • 0035948296 scopus 로고    scopus 로고
    • Wet agglomeration of powders: from physics toward process optimization
    • Goldszal A., and Bousquet J.h. Wet agglomeration of powders: from physics toward process optimization. Powder Technology 117 3 (2001) 221-231
    • (2001) Powder Technology , vol.117 , Issue.3 , pp. 221-231
    • Goldszal, A.1    Bousquet, J.h.2
  • 18
    • 33845437019 scopus 로고    scopus 로고
    • Golzi, R., Mancini, A., Marcelloni, L., Santus, G.C., Vanasia, A., 1992. Modeling and optimization of the particle size range from a wet granulation process in a high-shear mixer. Congres International Technologie Pharmaceutique, 6th, Paris, pp. 139-148.
  • 19
    • 0025944119 scopus 로고
    • Characterization of wet masses using a mixer torque rheometer: 1. Effect of instrument geometry
    • Hancock B.C., York P., Rowe R.C., and Parker M.D. Characterization of wet masses using a mixer torque rheometer: 1. Effect of instrument geometry. International Journal of Pharmaceutics 76 3 (1991) 239-245
    • (1991) International Journal of Pharmaceutics , vol.76 , Issue.3 , pp. 239-245
    • Hancock, B.C.1    York, P.2    Rowe, R.C.3    Parker, M.D.4
  • 20
    • 33845402934 scopus 로고    scopus 로고
    • Hiseman, M.J.P., Bridgwater, J., Wilson, D.I., 1996. Positron emission particle tracking studies of granulation in a planetary mixer. IChemE Research Event, European Conference for Young Researchers in Chemical Engineering, vol. 2, second ed., Leeds, UK, April 2-3, 1996, pp. 991-993.
  • 23
    • 0024014108 scopus 로고
    • The granulation of partially prewetted alumina powders-a new concept in coalescence mechanism
    • Huang C.C., and Kono H.O. The granulation of partially prewetted alumina powders-a new concept in coalescence mechanism. Powder Technology 55 1 (1988) 19-34
    • (1988) Powder Technology , vol.55 , Issue.1 , pp. 19-34
    • Huang, C.C.1    Kono, H.O.2
  • 24
    • 0031997774 scopus 로고    scopus 로고
    • A case study of particle mixing in a ploughshare mixer using positron emission particle tracking
    • Jones J.R., and Bridgwater J. A case study of particle mixing in a ploughshare mixer using positron emission particle tracking. International Journal of Mineral Processing 53 1-2 (1998) 29-38
    • (1998) International Journal of Mineral Processing , vol.53 , Issue.1-2 , pp. 29-38
    • Jones, J.R.1    Bridgwater, J.2
  • 25
    • 2342616651 scopus 로고    scopus 로고
    • A systematic approach to scale-up the high-shear granulation process for mebendazole tablets to achieve a scale-independent drug release
    • Kalaiselvan R., Prasad G.S., Madhusudhan S., Naik P.R., and Manavalan R. A systematic approach to scale-up the high-shear granulation process for mebendazole tablets to achieve a scale-independent drug release. Acta Pharmaceutica Turcica 46 1 (2004) 25-34
    • (2004) Acta Pharmaceutica Turcica , vol.46 , Issue.1 , pp. 25-34
    • Kalaiselvan, R.1    Prasad, G.S.2    Madhusudhan, S.3    Naik, P.R.4    Manavalan, R.5
  • 26
    • 0345201776 scopus 로고    scopus 로고
    • Influence of chopper and mixer speeds and microwave power level during the high-shear granulation process on the final granule characteristics
    • Kiekens F., Cordoba-Diaz M., and Remon J.P. Influence of chopper and mixer speeds and microwave power level during the high-shear granulation process on the final granule characteristics. Drug Development and Industrial Pharmacy 25 12 (1999) 1289-1293
    • (1999) Drug Development and Industrial Pharmacy , vol.25 , Issue.12 , pp. 1289-1293
    • Kiekens, F.1    Cordoba-Diaz, M.2    Remon, J.P.3
  • 27
    • 0034640762 scopus 로고    scopus 로고
    • An investigation of the effects on agglomeration of changing the speed of a mechanical mixer
    • Knight P.C., Johansen A., Kristensen H.G., Schaefer T., and Seville J.P.K. An investigation of the effects on agglomeration of changing the speed of a mechanical mixer. Powder Technology 110 3 (2000) 204-209
    • (2000) Powder Technology , vol.110 , Issue.3 , pp. 204-209
    • Knight, P.C.1    Johansen, A.2    Kristensen, H.G.3    Schaefer, T.4    Seville, J.P.K.5
  • 28
    • 33845417437 scopus 로고    scopus 로고
    • Kono, H.O., Huang, C.C., 1988. Dispersion of powder and liquid in granulators-realistic granulation mechanism and model. Proceedings-Institute for Briquetting and Agglomeration, Biennial Conference, West Virginia University, Morgantown, WV, USA, pp. 379-387.
  • 31
    • 0029945775 scopus 로고    scopus 로고
    • The effect of batch size on scale-up of a pharmaceutical granulation in a fixed bowl mixer granulator
    • Landin M., York P., Cliff M.J., Rowe R.C., and Wigmore A.J. The effect of batch size on scale-up of a pharmaceutical granulation in a fixed bowl mixer granulator. International Journal of Pharmaceutics 134 1-2 (1996) 243-246
    • (1996) International Journal of Pharmaceutics , vol.134 , Issue.1-2 , pp. 243-246
    • Landin, M.1    York, P.2    Cliff, M.J.3    Rowe, R.C.4    Wigmore, A.J.5
  • 32
    • 18644385416 scopus 로고    scopus 로고
    • Structure of powder flow in a planetary mixer during wet-mass granulation
    • Laurent B.F.C. Structure of powder flow in a planetary mixer during wet-mass granulation. Chemical Engineering Science 60 14 (2005) 3805-3816
    • (2005) Chemical Engineering Science , vol.60 , Issue.14 , pp. 3805-3816
    • Laurent, B.F.C.1
  • 33
  • 34
    • 18644379101 scopus 로고
    • Size enlargement of pharmaceutical powders by wet agglomeration and drying techniques
    • Leuenberger H. Size enlargement of pharmaceutical powders by wet agglomeration and drying techniques. Kona 11 (1993) 69-78
    • (1993) Kona , vol.11 , pp. 69-78
    • Leuenberger, H.1
  • 36
    • 0037453859 scopus 로고    scopus 로고
    • Scale up of wet granulation processes: science not art
    • Litster J.D. Scale up of wet granulation processes: science not art. Powder Technology 130 1-3 (2003) 35-40
    • (2003) Powder Technology , vol.130 , Issue.1-3 , pp. 35-40
    • Litster, J.D.1
  • 37
    • 33845464162 scopus 로고    scopus 로고
    • Litster, J.D., Waters, A.G., Nicol, S.K., 1989. Mechanisms of iron ore granulation. International Symposium on Agglomeration, 5th, Shortland, Australia, pp. 33-49.
  • 39
    • 0024029268 scopus 로고
    • Fundamental particle mixing studies in an agitated bed of granular materials in a cylindrical vessel
    • Malhotra K., Mujumdar A.S., Imakoma H., and Okazaki M. Fundamental particle mixing studies in an agitated bed of granular materials in a cylindrical vessel. Powder Technology 55 (1988) 107-114
    • (1988) Powder Technology , vol.55 , pp. 107-114
    • Malhotra, K.1    Mujumdar, A.S.2    Imakoma, H.3    Okazaki, M.4
  • 40
    • 0034694413 scopus 로고    scopus 로고
    • The effect of binder viscosity on particle agglomeration in a low shear mixer/agglomerator
    • Mills P.J.T., Seville J.P.K., Knight P.C., and Adams M.J. The effect of binder viscosity on particle agglomeration in a low shear mixer/agglomerator. Powder Technology 113 1-2 (2000) 140-147
    • (2000) Powder Technology , vol.113 , Issue.1-2 , pp. 140-147
    • Mills, P.J.T.1    Seville, J.P.K.2    Knight, P.C.3    Adams, M.J.4
  • 41
    • 0030969360 scopus 로고    scopus 로고
    • An application of the computer optimization technique to wet granulation process involving explosive growth of particles
    • Miyamoto Y., Ogawa S., Miyajima M., Matsui M., Sato H., Takayama K., and Nagai T. An application of the computer optimization technique to wet granulation process involving explosive growth of particles. International Journal of Pharmaceutics 149 1 (1997) 25-36
    • (1997) International Journal of Pharmaceutics , vol.149 , Issue.1 , pp. 25-36
    • Miyamoto, Y.1    Ogawa, S.2    Miyajima, M.3    Matsui, M.4    Sato, H.5    Takayama, K.6    Nagai, T.7
  • 43
    • 0013418163 scopus 로고    scopus 로고
    • Scale-up of agglomeration processes using transformations
    • Mort P., and Tardos G. Scale-up of agglomeration processes using transformations. Kona 17 (1999) 64-75
    • (1999) Kona , vol.17 , pp. 64-75
    • Mort, P.1    Tardos, G.2
  • 44
    • 0034599730 scopus 로고    scopus 로고
    • Numerical simulation of particulate flow with liquid bridge between particles (simulation of centrifugal tumbling granulator)
    • Muguruma Y., Tanaka T., and Tsuji Y. Numerical simulation of particulate flow with liquid bridge between particles (simulation of centrifugal tumbling granulator). Powder Technology 109 1-3 (2000) 49-57
    • (2000) Powder Technology , vol.109 , Issue.1-3 , pp. 49-57
    • Muguruma, Y.1    Tanaka, T.2    Tsuji, Y.3
  • 45
    • 33845462351 scopus 로고    scopus 로고
    • Ng, B., 2006. Modelling and analysis of the flow field of granular material in high shear mixer granulator, PhD Transfer Report, University of Leeds.
  • 46
    • 33845405050 scopus 로고    scopus 로고
    • Nilpawar, A.M., Reynolds, G.K., Salman, A.D., Hounslow, M.J., 2005. Velocity distribution in high shear granulator. World Congress of Chemical Engineering, Glasgow.
  • 47
    • 33845450516 scopus 로고    scopus 로고
    • Nilpawar, A.M., Reynolds, G.K., Salman, A.D., Hounslow, M.J., 2006a. Estimating aggregation efficiency from observation of flow behaviour in a high shear mixer. World Congress on Particle Technology, vol. 5, Orlando.
  • 52
  • 53
    • 0142026019 scopus 로고    scopus 로고
    • Quantifying liquid coverage and powder flux in high-shear granulators
    • Plank R., Diehl B., Grinstead H., and Zega J. Quantifying liquid coverage and powder flux in high-shear granulators. Powder Technology 143 3 (2003) 223-234
    • (2003) Powder Technology , vol.143 , Issue.3 , pp. 223-234
    • Plank, R.1    Diehl, B.2    Grinstead, H.3    Zega, J.4
  • 55
    • 0035124025 scopus 로고    scopus 로고
    • Using experimental design to optimize the process parameters in fluidized bed granulation
    • Rambali B., Baert L., Thone D., and Massart D.L. Using experimental design to optimize the process parameters in fluidized bed granulation. Drug Development and Industrial Pharmacy 27 1 (2001) 47-55
    • (2001) Drug Development and Industrial Pharmacy , vol.27 , Issue.1 , pp. 47-55
    • Rambali, B.1    Baert, L.2    Thone, D.3    Massart, D.L.4
  • 57
    • 0038175092 scopus 로고    scopus 로고
    • Using deepest regression method for optimization of fluidized bed granulation on semi-full scale
    • Rambali B., Van Aelst S., Baert L., and Massart D.L. Using deepest regression method for optimization of fluidized bed granulation on semi-full scale. International Journal of Pharmaceutics 258 1-2 (2003) 85-94
    • (2003) International Journal of Pharmaceutics , vol.258 , Issue.1-2 , pp. 85-94
    • Rambali, B.1    Van Aelst, S.2    Baert, L.3    Massart, D.L.4
  • 59
    • 0023909986 scopus 로고
    • Influence of liquid bonding strength on power consumption during granulation in a high shear mixer
    • Ritala M., Holm P., Schaefer T., and Kristensen H.G. Influence of liquid bonding strength on power consumption during granulation in a high shear mixer. Drug Development and Industrial Pharmacy 14 8 (1988) 1041-1060
    • (1988) Drug Development and Industrial Pharmacy , vol.14 , Issue.8 , pp. 1041-1060
    • Ritala, M.1    Holm, P.2    Schaefer, T.3    Kristensen, H.G.4
  • 65
    • 0033862482 scopus 로고    scopus 로고
    • Scaleup of a high-shear granulation process using a normalized impeller work parameter
    • Sirois P.J., and Craig G.D. Scaleup of a high-shear granulation process using a normalized impeller work parameter. Pharmaceutical Development and Technology 5 3 (2000) 365-374
    • (2000) Pharmaceutical Development and Technology , vol.5 , Issue.3 , pp. 365-374
    • Sirois, P.J.1    Craig, G.D.2
  • 67
    • 0034194149 scopus 로고    scopus 로고
    • Computer simulation of wet granulation
    • Talu I., Tardos G.I., and Khan M.I. Computer simulation of wet granulation. Powder Technology 110 1-2 (2000) 59-75
    • (2000) Powder Technology , vol.110 , Issue.1-2 , pp. 59-75
    • Talu, I.1    Tardos, G.I.2    Khan, M.I.3
  • 68
    • 33845397854 scopus 로고    scopus 로고
    • Wet-granulation research with application to scale-up
    • Tardos G.I. Wet-granulation research with application to scale-up. China Particuology 3 3 (2005) 191-195
    • (2005) China Particuology , vol.3 , Issue.3 , pp. 191-195
    • Tardos, G.I.1
  • 69
    • 0342378046 scopus 로고    scopus 로고
    • Critical parameters and limiting conditions in binder granulation of fine powders
    • Tardos G.I., Irfan Khan M., and Mort P.R. Critical parameters and limiting conditions in binder granulation of fine powders. Powder Technology 94 3 (1997) 245-258
    • (1997) Powder Technology , vol.94 , Issue.3 , pp. 245-258
    • Tardos, G.I.1    Irfan Khan, M.2    Mort, P.R.3
  • 71
    • 0030573074 scopus 로고    scopus 로고
    • Doehlert experimental design applied to optimization and quality control of a granulation process in a high shear mixer
    • Vojnovic D., Chicco D., and El Zenary H. Doehlert experimental design applied to optimization and quality control of a granulation process in a high shear mixer. International Journal of Pharmaceutics 145 1-2 (1996) 203-213
    • (1996) International Journal of Pharmaceutics , vol.145 , Issue.1-2 , pp. 203-213
    • Vojnovic, D.1    Chicco, D.2    El Zenary, H.3


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