Scaling up of the fluidized bed granulation process

International Journal of Pharmaceutics

Volumn 252, Issue 1-2, 2003, Pages 197-206

  Rambali, B ^a   Baert, L ^b   Massart, D L ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Experimental design; Fluid bed; Granulation process; Granule size; Scaling up

Indexed keywords

ARTICLE; COMPARATIVE STUDY; EXPERIMENTAL DESIGN; METHODOLOGY; MOISTURE; PRIORITY JOURNAL; SCALE UP; SPRAY DRYING; STATISTICAL ANALYSIS;

EID: 0037452433     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00646-4     Document Type: Article

References (15)

1. Holm P., Schaefer T., Kristensen H.G. Granulation in high speed mixers. Part 1. Effects of process variables during kneading. Pharm. Ind. 45:1983;806-811.
2. Leuenberger H. Scale-up of granulation processes with reference to process monitoring. Acta Pharm. Technol. 29:1983;274-280.
3. Kristensen H.G. Agglomeration of powders. Acta Pharm. Suec. 25:1988;187-204.
4. Mehta A.M. Scale-up considerations in the fluid-bed process for controlled-release products. Pharm. Tech. 12:1988;46-52.
5. Montgomery, D.C., 1997. Design and Analysis of Experiments. Wiley, Singapore, pp. 276-281.
6. Parikh, D.M., Bonck, J.A., Mogavero, M., 1997. Batch fluid bed granulation. In: Parikh, D.M. (Ed.), Handbook of Pharmaceutical Granulation Technology. Marcel Dekker, New York, pp. 227-302.
7. Rambali B., Baert L., Thoné D., Massart D.L. Using experimental design to optimise the granulation process in fluid bed. Drug Dev. Ind. Pharm. 27:2001a;53-61.
8. Rambali B., Baert L., Thoné D., Massart D.L. Using experimental design to optimize the process parameters in fluidized bed granulation on semi full scale. Int. J. Pharm. 220:2001b;149-160.
9. Schaafsma, S.H., 2000. Down-scaling of a fluidised bed agglomeration process. Ph.D. dissertation of Rijksuniversiteit Groningen, 159 pp.
10. Schaefer T., Worts O. Control of fluidized bed granulation. II. Estimation of droplet size of atomized binder solutions. Arch. Pharm. Chemi. Sci. Ed. 5:1977;178-193.
11. Schaefer T., Worts O. Control of fluidized bed granulation. IV. Effects of binder solution and atomization on granule size and size distribution. Arch. Pharm. Chemi. Sci. Ed. 6:1978;14-25.
12. Sherrington, P.J., Oliver, R., 1981. Granulation. Heyden & Son Ltd., London, pp. 7-60.
13. Watano S., Morikawa T., Miyanami K. Mathematical model in the kinetics of agitation fluidized bed granulation. Effects of humidity content, damping speed and operation time on granule growth rate. Chem. Pharm. Bull. 44:1996a;409-415.
14. Watano S., Fukushima T., Miyanami K. Heat transfer and granule growth rate in fluidized bed granulation. Chem. Pharm. Bull. 44:1996b;572-576.
15. Watano S., Takashima H., Sato Y., Yasutomo T., Miyanami K. Measurement of humidity content by IR sensor in fluidized bed granulation. Effects of operating variables on the relationship between granule humidity content and absorbance of IR spectra. Chem. Pharm. Bull. 44:1996c;1267-1269.