The effect of batch size on scale-up of a pharmaceutical granulation in a fixed bowl mixer granulator

International Journal of Pharmaceutics

Volumn 134, Issue 1-2, 1996, Pages 243-246

  Landin, M ^a   York, P ^a   Cliff, M J ^b   Rowe, R C ^b   Wigmore, A J ^c  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Aeromatic Fielder Ltd   (United Kingdom)

Author keywords

Batch size; Granulation; Mixer granulators; Scale up

Indexed keywords

LACTOSE; STARCH;

APPARATUS; ARTICLE; DRUG GRANULATION; FORCE; MASS; POWDER; PRIORITY JOURNAL; VELOCITY;

EID: 0029945775     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04461-4     Document Type: Article

References (4)

1. Cliff, M.J. and Parker M.D., Scale-up of mixer granulators. In: Proceedings of the 12th Interphex Conference, 1990, pp. 5/17-5/32.
2. Landin, M., York, P., Cliff, M.J., Rowe, R.C. and Wigmore, A. J., Scale-up of a pharmaceutical granulation in fixed bowl mixer granulators. Int. J. Pharm., 123 (1996) 127-131.
3. Parker, M.D., Rowe, R.C. and Upjohn, N.G., Mixer torque rheometry - a method for quantifying the consistency of wet granulations. Pharm. Tech. Int., 2 (1990) 50-62.
4. Timko, R.J., Cliff, M.J. and Rosenberg, H.A., High-intensity mixer granulators. In: Kadam, K.L. (Ed.), Granulation Technology for Bioproducts, CRC press, Boston, 1990, pp. 119-178.