Melt granulation in a high shear mixer: Optimization of mixture and process variables using a combined experimental design

Chemometrics and Intelligent Laboratory Systems

Volumn 48, Issue 1, 1999, Pages 59-70

  Campisi, B ^a   Vojnovic, D ^a   Chicco, D ^a   Phan Tan Luu, R ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

High shear mixer; Melt granulation; Mixture process variable approach; Response surface methodology

Indexed keywords

DRUG VEHICLE; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MACROGOL 6000; MC AVICEL PH 101; METHOCEL E5 PREMIUM; MICROCRYSTALLINE CELLULOSE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMOMETRICS; CRYSTALLIZATION; DRUG GRANULATION; DRUG GRANULE; DRUG MIXTURE; EXPERIMENTAL MODEL; MELTING POINT; PRIORITY JOURNAL; RESPONSE TIME; SHEAR RATE; VELOCITY;

EID: 0033553872     PISSN: 01697439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-7439(99)00008-8     Document Type: Article

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