Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings

Biotechnology and Bioengineering

Volumn 95, Issue 6, 2006, Pages 1198-1206

  Schmitmeier, Stephanie ^a   Langsch, Angelika ^b   Jasmund, Inka ^c   Bader, Augustinus ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^c Competence Centre for Tissue Engineering ^*  (Germany)

Author keywords

Culture systems; Liver specific functions; Oxygenation; Pharmacological screening; Primary porcine hepatocytes; Small scale bioreactor

Indexed keywords

BIOLOGICAL ORGANS; CELL CULTURE; PHYSIOLOGICAL MODELS; SCREENING; TOXICITY;

CULTURE SYSTEMS; LIVER-SPECIFIC FUNCTIONS; OXYGENATION; PHARMACOLOGICAL SCREENING; PRIMARY PORCINE HEPATOCYTES; SMALL-SCALE BIOREACTORS;

BIOREACTORS;

ALBUMIN; LACTATE DEHYDROGENASE; UREA;

ANIMAL CELL; ARTICLE; BIOARTIFICIAL LIVER; BIOREACTOR; BIOTRANSFORMATION; CELL ISOLATION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; GAS PERMEABILITY; GLUCOSE INTAKE; IN VITRO STUDY; LIVER CELL CULTURE; MEMBRANE PERMEABILITY; NONHUMAN; PROTEIN SECRETION; SCREENING TEST;

ALBUMINS; ANIMALS; BIOREACTORS; CELL DIFFERENTIATION; CHEMISTRY, PHARMACEUTICAL; EQUIPMENT DESIGN; FEMALE; HEPATOCYTES; LACTATES; LIVER; LIVER, ARTIFICIAL; MICROSCOPY, PHASE-CONTRAST; OXYGEN; SWINE; TECHNOLOGY, PHARMACEUTICAL; UREA;

ANIMALIA; SUIDAE;

EID: 33845386789     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21089     Document Type: Article

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