Novel GPCR screening approach: Indirect identification of S1P receptor agonists in antagonist screening using a calcium assay

Journal of Receptors and Signal Transduction

Volumn 26, Issue 5-6, 2006, Pages 549-575

  Siehler, Sandra ^a   Guerini, Danilo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apparent antagonism; Calcium measurements; G protein coupled receptors; Receptor desensitization; Sphingosine 1 phosphate receptors

Indexed keywords

CALCIUM; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHOLIPASE C; RECEPTOR BLOCKING AGENT; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; SPHINGOSINE 1 PHOSPHATE RECEPTOR AGONIST; SPHINGOSINE 1 PHOSPHATE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ASSAY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG SCREENING; GENE EXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

CALCIUM; CALCIUM SIGNALING; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; LIGANDS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOSPHINGOLIPID; TRANSFECTION;

EID: 33845213737     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1080/10799890600932246     Document Type: Conference Paper

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