Research articles mechanisms of hexachlorobenzene-induced adverse immune effects in brown Norway rats

Journal of Immunotoxicology

Volumn 1, Issue 3-4, 2005, Pages 167-175

  Ezendam, Janine ^a   Vos, Joseph G ^a,b   Pieters, Raymond ^c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33845202652     PISSN: 1547691X     EISSN: None     Source Type: Journal    
DOI: 10.1080/15476910490907026     Document Type: Review

References (62)

1. Albers, R., Broeders, A., van der Pijl, A., Seinen, W., and Pieters, R. 1997. The use of reporter antigens in the popliteal lymph node assay to assess immunomodulation by chemicals. Toxicol. Appl. Pharmacol. 143(1):102-109.
2. Alvarez, L., Randi, A., Alvarez, P., Piroli, G., Chamson-Reig, A., Lux-Lantos, V., and Kleiman de Pisarev, D. 2000. Reproductive effects of hexachlorobenzene in female rats. J. Appl. Toxicol. 20(1):81-87.
3. Anderson, C. C., and Matzinger, P. 2000. Danger: The view from the bottom of the cliff. Semin. Immunol. 12(3):231-238.
4. Barker, R. N., Erwig, L., Pearce, W. P., Devine, A., and Rees, A. J. 1999. Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages. Pathobiology 67(5-6):302-305.
5. Barnett, J. B., Barfield, L., Walls, R., Joyner, R., Owens, R., and Soderberg, L. S. 1987. The effect of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice. Toxicol. Lett. 39:263.
6. Bickers, D. R. 1987. The dermatologic manifestations of human porphyria. Ann. N. Y. Acad. Sci. 514:261-267.
7. Cam, C. 1958. Cases of skin porphyria related to hexachlorobenzene intoxication. Saglik Dergisi 32:215-216.
8. Cam, C. 1960. Une nouvelle dermatose épidémique des enfants. Anales de Dermatologie 87:393-397.
9. Courtney, K. D. 1979. Hexachlorobenzene (HCB): A review. Environ. Res. 20(2):225-266.
10. Cripps, D. J., Peters, H. A., Gocmen, A., and Dogramici, I. 1984. Porphyria turcica due to hexachlorobenzene: A 20 to 30 year follow-up study on 204 patients. Br. J. Dermatol 111(4):413-422.
11. Curtsinger, J. M., Schmidt, C. S., Mondino, A., Lins, D. C., Kedl, R. M., Jenkins, M. K., and Mescher, M. F. 1999. Inflammatory cytokines provideathird signal for activation of naive CD4+ and CD8+ T-cells. J. Immunol. 162(6):3256-3262.
12. Damoiseaux, J. G., Dopp, E. A., and Dijkstra, C. D. 1991. Cellular binding mechanism on rat macrophages for sialylated glycoconjugates, inhibited by the monoclonal antibody ED3. J. Leukoc. Biol. 49(5):434-441.
13. Daniell, W. E., Stockbridge, H. L., Labbe, R. F., Woods, J. S., Anderson, K. E., Bissell, D. M., Bloomer, J. R., Ellefson, R. D., Moore, M. R., Pierach, C. A., Schreiber, W. E., Tefferi, A., and Franklin, G. M. 1997. Environmental chemical exposures and disturbances of heme synthesis. Environ. Health Perspect. 105 (Suppl.) 1:37-53.
14. Dijkstra, C. D., Dopp, E. A., Huitinga, I., and Damoiseaux, J. G. 1992. Macrophages in experimental autoimmune diseases in the rat: A review. Curr. Eye. Res. 11(Suppl.):75-79.
15. Dijkstra, C. D., Dopp, E. A., Vogels, I. M., and Van Noorden, C. J. 1987. Macrophages and dendritic cells in antigen-induced arthritis. An immunohistochemical study using cryostat sections of the whole knee joint of rat. Scand. J. Immunol. 26(5):513-523.
16. Donker, A. J., Venuto, R. C., Vladutiu, A. O., Brentjens, J. R., and Andres, G. A. 1984. Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation. Clin. Immunol. Immunopathol. 30(1):142-155.
17. Driscoll, K. E., Lindenschmidt, R. C., Maurer, J. K., Higgins, J. M., and Ridder, G. 1990. Pulmonary responsetosilicaortitanium dioxide: inflammatory cells, alveolar macrophage-derived cytokines, and histopathology. Am. J. Respir. Cell. Mol. Biol. 2(4):381-390.
18. Elder, G. H., editor. 1978. Porphyria caused by hexachlorobenzene and other polyhalogenated aromatic hydrocarbons, pp. 157-200. Springer-Verlag, Heidelberg-New York.
19. Ezendam, J. 2004. Mechanisms of Hexachlorobenzene-Induced Adverse Immune Effects. Utrecht University, Utrecht.
20. Ezendam, J., Hassing, I., Bleumink, R., Vos, J. G., and Pieters, R. 2004a. Hexachlorobenzene-induced immunopathology in Brown Norway rats is partly mediated by T-cells. Toxicol. Sci. 78:88-95.
21. Ezendam, J., Staedtler, F., Pennings, J., Vandebriel, R. J., Pieters, R., Boffetta, P., Harleman, J. H., and Vos, J. G. 2004b. Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats. Environ. Health Perspect. 112(7):782-791.
22. Ezendam, J., Vissers, I., Bleumink, R., Vos, J. G., and Pieters, R. 2003. Immunomodulatory effects of tetrachlorobenzoquinone, a reactive retabolite of hexachlorobenzene. Chem. Res. Toxicol. 16(6):688-694.
23. Foster, W. G., McMahon, A., Younglai, E. V., Jarrell, J. F., and Lecavalier, P. 1995. Alterations in circulating ovarian steroids in hexachlorobenzeneexposed monkeys. Reprod. Toxicol. 9(6):541-548.
24. Fournie, G. J., Mas M., Cautain, B., Savignac, M., Subra, J. F., Pelletier, L., Saoudi, A., Lagrange, D., Calise, M., and Druet, P. 2001. Induction of autoimmunity through bystander effects. Lessons from immunological disorders induced by heavy metals. J. Autoimmun. 16(3):319-326.
25. Franklin, M. R., Phillips, J. D., and Kushner, J. P. 1997. Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda. Toxicol. Appl. Pharmacol. 147(2):289-299.
26. Gallucci, S., Lolkema, M., and Matzinger, P. 1999. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5(11):1249-1255.
27. Gleichmann, E., Kimber, I., and Purchase, I. F. 1989. Immunotoxicology: Suppressive and stimulatory effects of drugs and environmental chemicals on the immune system. A discussion. Arch. Toxicol. 63(4):257-273.
28. Gocmen, A., Peters, H. A., Cripps, D. J., Morris, C. R., and Dogramaci, I. 1986. Porphyria turcica: hexachlorobenzene-induced porphyria. C. Morris, J. R., Cabral, eds. pp. 567-573. Hexachlorobenzene: Proceedings of an International Symposium. IARC Scientific Publications No. 77, Lyon.
29. Gossart, S., Cambon, C., Orfila, C., Seguelas, M. H., Lepert, J. C., Rami, J., Carre, P., and Pipy, B. 1996. Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica. J. Immunol. 156(4):1540-1548.
30. Griem, P., Wulferink, M., Sachs, B., Gonzalez, J. B., and Gleichmann, E. 1998. Allergic and autoimmune reactions to xenobiotics: How do they arise? Immunol. Today 19(3):133-141.
31. Li, M., Carpio, D. F., Zheng, Y., Bruzzo, P., Singh, V., Ouaaz, F., Medzhitov, R. M., and Beg, A. A. 2001. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J. Immunol. 166(12):7128-7135.
32. Loose, L. D., Silkworth, J. B., Pittman, K. A., Benitz, K. F., and Mueller, W. 1978. Impaired host resistance to endotoxin and malaria in polychlorinated biphenyl-and hexachlorobenzene-treated mice. Infect. Immun. 20(1):30-35.
33. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045.
34. Michielsen, C. C., Bloksma, N., Klatter, F. A., Rozing, J., Vos, J. G., and van Dijk, J. E. 1999a. The role of thymus-dependent T-cells in hexachlorobenzene-induced inflammatory skin and lung lesions. Toxicol. Appl. Pharmacol. 161(2):180-191.
35. Michielsen, C. P., Bloksma, N., Ultee, A., van Mil, F., and Vos, J. G. 1997. Hexachlorobenzene-induced immunomodulation and skin and lung lesions: A comparison between Brown Norway, Lewis, and Wistar rats. Toxicol. Appl. Pharmacol. 144(1):12-26.
36. Michielsen, C., Boeren, S., Rietjens, I., van Mil, F., Vos, J., and Bloksma, N. 2000. The mercapturic acid biotransformation pathwayof hexachlorobenzene is not involved in the induction of splenomegaly, or skin and lung lesions in the Brown Norway rat. Arch. Toxicol. 74(10):609-617.
37. Michielsen, C. P., Leusink-Muis, A., Vos, J. G., and Bloksma, N. 2001. Hexachlorobenzene-induced eosinophilic and granulomatous lung inflammation is associated with in vivo airways hyperresponsiveness in the Brown Norway rat. Toxicol. Appl. Pharmacol. 172(1):11-20.
38. Michielsen, C. C., van Loveren, H., and Vos, J. G. 1999b. The role of the immune system in hexachlorobenzene-induced toxicity. Environ. Health Perspect. 107(Suppl 5):783-792.
39. Michielsen, C., Zeamari, S., Leusink-Muis, A., Vos, J., and Bloksma, N. 2002. The environmental pollutant hexachlorobenzene causes eosinophilic and granulomatous inflammation andin vitroairways hyperreactivity in the Brown Norway rat. Arch. Toxicol. 76(4):236-247.
40. Peters, H., Cripps, D., Gocmen, A., Bryan, G., Erturk, E., and Morris, C. 1987. Turkish epidemic hexachlorobenzene porphyria. A 30-year study. Ann. N. Y. Acad. Sci. 514:183-190.
41. Pichler, W. J. 2001. Drug allergy. Curr. Opin. Allergy Clin. Immunol. 1(4):285-286.
42. Pieters, R., Ezendam, J., and Nierkens, S. 2003. Chemical-specific properties co-determine the typeofadverse immune response. Autoimmun. Rev. 2(1):25-29.
43. Queiroz, M. L., Bincoletto, C., Perlingeiro, R. C., Quadros, M. R., and Souza, C. A. 1998a. Immunoglobulin levels in workers exposed to hexachlorobenzene. Hum. Exp. Toxicol. 17(3):172-175.
44. Queiroz, M. L., Quadros, M. R., Valadares, M. C., and Silveira, J. P. 1998b. Polymorphonuclear phagocytosis and killing in workers occupationally exposed to hexachlorobenzene. Immunopharmacol. Immunotoxicol. 20(3):447-454.
45. Ralph, J. L., Orgebin-Crist, M. C., Lareyre, J. J., and Nelson, C. C. 2003. Disruption of androgen regulation in the prostate by the environmental contaminant hexachlorobenzene. Environ. Health Perspect. 111(4):461-466.
46. Sauter, B., Albert, M. L., Francisco, L., Larsson, M., Somersan, S., and Bhardwaj, N. 2000. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191(3):423-434.
47. Schielen, P., Den Besten, C., Vos, J. G., Van Bladeren, P. J., Seinen, W., and Bloksma, N. 1995a. Immune effects of hexachlorobenzene in the rat: Role of metabolismina13-week feeding study. Toxicol. Appl. Pharmacol. 131(1):37-43.
48. Schielen, P., Schoo, W., Tekstra, J., Oostermeijer, H. H., Seinen, W., and Bloksma, N. 1993. Autoimmune effects of hexachlorobenzene in the rat. Toxicol. Appl. Pharmacol. 122(2):233-243.
49. Schielen, P., Van Rodijnen, W., Pieters, R. H., and Seinen, W. 1995b. Hexachlorobenzene treatment increases the number of splenic B-1-like cells and serum autoantibody levels in the rat. Immunology 86(4):568-574.
50. Seguin, B., and Uetrecht, J. 2003. The danger hypothesis applied to idiosyncratic drug reactions. Curr. Opin. Allergy. Clin. Immunol. 3(4):235-242.
51. Shenton, J. M., Teranishi, M., Abu-Asab, M. S., Yager, J. A., and Uetrecht, J. P. 2003. Characterization of a potential animal model of an idiosyncratic drug reaction: Nevirapine-induced skin rash in the rat. Chem. Res. Toxicol. 16(9):1078-1089.
52. Stoy, N. S. 2002. Monocyte/macrophage initiation of organ-specific autoimmunity: The ultimate 'bystander' hypothesis? Med. Hypotheses 58(4):312-326.
53. Uetrecht, J. 1990. Drug metabolism by leukocytes and its role in drug-induced lupus and other idiosyncratic drug reactions. Crit. Rev. Toxicol. 20(4):213-235.
54. Uetrecht, J. P. 1997. Current trends in drug-induced autoimmunity. Toxicology 119(1):37-43.
55. Van Ommen, B., Adang, A. E., Brader, L., Posthumus, M. A., Muller, F., and van Bladeren, P. J. 1986. The microsomal metabolism of hexachlorobenzene. Origin of the covalent binding to protein. Biochem. Pharmacol. 35(19):3233-3238.
56. Van Ommen, B., van Bladeren, P. J., Temmink, J. H., and Muller, F. 1985. Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene. Biochem. Biophys. Res. Commun. 126(1):25-32.
57. Van Rooijen, N. 1989. The liposome-mediated macrophage 'suicide' technique. J. Immunol. Meth. 124(1):1-6.
58. Vandebriel, R. J., Meredith, C., Scott, M. P., van Dijk, M., and van Loveren, H. 2000. Interleukin-10 is an unequivocal Th2 parameter in the rat, whereas interleukin-4 is not. Scand. J. Immunol. 52(5):519-524.
59. Vos, J. G. 1986. Immunotoxicity of hexachlorobenzene. In Hexachlorobenzene: Proceedings of an International Symposium (C. R. Morris, J. R. Cabral, Eds.), pp. 347-356. IARC Scientific Publications, Lyon, France.
60. Vos, J. G., Brouwer, G. M. J., Van Leeuwen, F. X. R., and Wagenaar, S. 1983. Toxicity of hexachlorobenzene in the rat following combined pre-and postnatal exposure: Comparison of effects on immune system, liver and lung. In: Immunotoxicology (D. V. Parke, G. G. Gibson, and R. Hubard, eds.), pp. 219-235, Academic Press, London.
61. Vos, J. G., Van Logten, M. J., Kreeftenberg, J. G., and Kruizinga, W. 1979a. Hexachlorobenzene-induced stimulationof the humoral response in rats. Ann. N. Y. Acad. Sci. 320:535-550.
62. Vos, J. G., van, Logten, M. J., Kreeftenberg, J. G., Steerenberg, P. A., and Kruizinga, W. 1979b. Effect of hexachlorobenzene on the immune system of rats following combined pre-and postnatal exposure. Drug. Chem. Toxicol. 2(1-2):61-76.