Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda

Toxicology and Applied Pharmacology

Volumn 147, Issue 2, 1997, Pages 289-299

  Franklin, Michael R ^a   Phillips, John D ^a   Kushner, James P ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; AROCLOR 1254; CYTOCHROME P450; HEXACHLOROBENZENE; IRON; PORPHYRIN; UROPORPHYRINOGEN DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; MALE; NONHUMAN; PORPHYRIA CUTANEA TARDA; RAT; SEX DIFFERENCE;

EID: 0031430858     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8282     Document Type: Article

References (36)

1. Bowers M. A., Luckhurst C. L., Davis H. A., Woods J. S. Investigation of factors influencing urinary porphyrin excretion in rats: Strain, gender and age. Fundam. Appl. Toxicol. 19:1992;538-544.
2. Burke M. D., Mayer R. T. Inherent specificities of purified cytochromes P450 and P448 toward biphenyl hydroxylation and ethoxyresorufin deethylation. Drug Metab. Dispos. 3:1975;245-253.
3. Cam C., Nigogoysan G. Acquired toxic porphyria cutanea tarda due to hexachlorobenzene. JAMA. 183:1963;88-91.
4. d. Biochem. Pharmacol. 52:1996;1407-1413.
5. Cripps D. J., Gocman A., Peters H. A. Porphyria turcica. Twenty years after hexachlorobenzene intoxication. Arch. Dermatol. 116:1980;46-50.
6. Deam S., Elder G. H. Uroporphyria produced in mice by iron and 5-aminolevulinic acid. Biochem. Pharmacol. 41:1991;2019-2022.
7. Den Besten C., Bennik M. H. J., Bruggeman I., Schielen P., Kuper F., Brouwer A., Koeman J. H., Vos J. G., Van Bladeren P. J. The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: A comparison with pentachlorobenzene in a 13-week feeding study. Toxicol. Appl. Pharmacol. 119:1993;181-194.
8. Ford E. R., Ou C-N., Ellefson R. D. Liquid-chromatographic analysis for urinary porphyrins. Clin. Chem. 27:1981;397-401.
9. Franklin M. R., Estabrook R. W. On the inhibitory action of mersalyl on microsomal drug oxidation. A rigid organization of the electron transport chain. Arch. Biochem. Biophys. 143:1971;318-329.
10. Hahn M. E., Gasiewicz T. A., Linko P., Goldstein J. A. The role of theAh. Biochem. J. 254:1988;245-254.
11. Kappas A., Sassa S., Galbraith R. A., Nordmann Y. The Porphyrias. The Metabolic Basis of Inherited Disease. 1989;McGraw-Hill, New York. p. 1305-1365.
12. Kennedy S. W., Wigfield D. C. Dose-response relationshipsin hexachlorobenzene-induced porphyria. Biochem Pharmacol. 40:1989;1381-1388.
13. Klotz A. V., Stegeman J. J., Walsh C. An alternative 7-ethoxyresorufin O-deethylase activity assay. A continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity. Anal. Biochem. 140:1984;138-145.
14. Lambrecht R. W., Sinclair P. R., Gorman N., Sinclair J.F. Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P4501A2. Arch. Biochem. Biophys. 294:1992;504-510.
15. Louw M., Neethling A. C., Percy V. A., Carstens M., Shanley B.C. Effects of hexachlorobenzene feeding and iron overload on enzymes of haem biosynthesis and cytochrome P450 in rat liver. Clin. Sci. Mol. Med. 53:1977;111-115.
16. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Lubet R. A., Mayer R. T., Cameron J. W., Nims R. W., Burke M. D., Wolff T., Guengerich F. P. Dealkylation of pentoxyresorufin. A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238:1985;43-48.
18. Nerurkar P. V., Park S. S., Thomas P. E., Nims R. W., Lubet R. A. Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol. 46:1993;933-943.
19. Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:1964;2370-2378.
20. Poland A., Knutson J. C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogen aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22:1982;517-529.
21. Schmid R. Cutaneous porphyria in Turkey. N. Engl. J. Med. 263:1960;397-398.
22. Sinclair P. R., Gorman N., Walton H. S., Bement W. J., Jacobs J. M., Sinclair J. F. Ascorbic acid inhibition of cytochrome P450-catalyzed uroporphyrin accumulation. Arch. Biochem. Biophys. 304:1993;464-470.
23. Sinclair P. R., Gorman N., Sinclair J. F., Walton H. S., Bement W. J., Lambrecht R. W. Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats. Hepatology. 22:1995;565-572.
24. Smith A. G., Francis J. E. Genetic variation of iron-induced uropophyria in mice. Biochem. J. 291:1993;29-35.
25. Smith A. G., Francis J. E. Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice. Biochem. J. 214:1983;909-913.
26. Smith A. G., Cabral J. R. P., DeMatteis F. A difference between two strains of rats in their liver non-haem iron content and in their response to the porphyrogenic effect of hexachlorobenzene. Chem. -Biol. Interact. 27:1979;353-363.
27. Smith A. G., Carthew P., Clothier B., Constantin D., Francis J. E., Madra S. Synergy of iron in the toxicity and carcinogenicity of polychlorinated biphenyls (PCBs) and related chemicals. Toxicol. Lett. 82/83:1995;945-950.
28. Smith A. G., Carthew P., Francis J. E., Cabral J. R. P., Manson M. M. Enhancement by iron of hepatic neoplasia in rats caused by hexachlorobenzene. Carcinogenesis. 7:1993;1381-1387.
29. Smith A. G., Francis J. E., Bird I. Distinction between octachlorostyrene and hexachlorobenzene in their potentials to induce ethoxyphenoxazone deethylase and cause porphyria in rats and mice. J. Biochem. Toxicol. 1:1986;105-117.
30. Smith A. G., Francis J. E., Green J. A., Greig J. B., Wolf C. R., Manson M. M. Sex-linked hepatic uroporphyria and the induction of cytochromes P4501A in rats caused by hexachlorobenzene and polyhalogenated biphenyls. Biochem. Pharmacol. 40:1990;2059-2068.
31. Smith A. G., Francis J. E., Dinsdale D., Manson M. M., Cabral J. R. P. Hepatocarcinogenicity of hexachlorobenzene in rats and the sex difference in hepatic iron status and development of porphyria. Carcinogenesis. 6:1985;631-636.
32. Straka J. G., Kushner J. P., Pryor M. A. Uroporphyrinogen decarboxylase. A method for measuring enzyme activity. Enzyme. 28:1982;170-185.
33. Taljaard J. J. F., Shanley B. C., Deppe W. M., Joubert S. M. Porphyrin metabolism in experimental hepatic siderosis in the rat. II. Combined effect of iron overload and hexachlorobenzene. Brit. J. Haematol. 23:1972;513-519.
34. Urquhart A. J., Elder G. H., Roberts A. G., Lambrecht R. W., Sinclair P. R., Bement W. J., Gorman N., Sinclair J. A. Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid. Biochem. J. 253:1988;357-362.
35. With T. K. Porphyrin concentration from ultraviolet extinction. Scand. J. Clin. Lab. Invest. 7:1955;193-196.
36. Wyckoff E. E., Kushner J. P. Heme biosynthesis, the porphyrias, and the liver. Arias I. M., Boyer J. L., Fauston N., Jakoby W. B., Schacter D. A., Shofritz A. The Liver: Biology and Pathobiology. 1994;505-527 Raven Press, New York.