The mercapturic acid biotransformation pathway of hexachlorobenzene is not involved in the induction of splenomegaly, or skin and lung lesions in the Brown Norway rat

Archives of Toxicology

Volumn 74, Issue 10, 2000, Pages 609-617

  Michielsen, C ^a   Boeren, S ^b   Rietjens, I ^b   Van Mil, F ^a   Vos, J ^a,c   Bloksma, N ^d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Biotransformation; Brown Norway rat; Hexachlorobenzene; HPLC; LC MS; Lung pathology; Mercapturic acid pathway; Pentachloronitrobenzene; Pentachlorophenol; Skin pathology; Splenomegaly

Indexed keywords

ACETYLCYSTEINE; HEXACHLOROBENZENE; PENTACHLOROPHENOL; QUINTOZENE;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INFLAMMATION; LIQUID CHROMATOGRAPHY; LIVER WEIGHT; LUNG INJURY; MASS SPECTROMETRY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN DEFECT; SPLEEN WEIGHT; SPLENOMEGALY; URINE LEVEL; WEIGHT GAIN;

ACETYLCYSTEINE; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FUNGICIDES, INDUSTRIAL; HEXACHLOROBENZENE; LIVER; LUNG; MASS SPECTROMETRY; NITROBENZENES; ORGAN SIZE; RATS; RATS, INBRED STRAINS; SKIN; SPLEEN; SPLENOMEGALY;

EID: 0034541574     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000166     Document Type: Article

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