Structural insights into autoreactive determinants in thyroid peroxidase composed of discontinuous and multiple key contact amino acid residues contributing to epitopes recognized by patients' autoantibodies

Endocrinology

Volumn 147, Issue 12, 2006, Pages 5995-6003

  Dubska, Marlena ^a   Banga, J Paul ^b   Plochocka, Danuta ^c   Hoser, Grazyna ^a   Kemp, E Helen ^d   Sutton, Brian J ^b   Gardas, Andrzej ^a   Gora, Monika ^a,c  

^a MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AUTOANTIBODY; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; THYROID PEROXIDASE;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; HASHIMOTO DISEASE; IMMUNOLOGICAL TOLERANCE; NONHUMAN; OVARY CELL; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, SURFACE; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BINDING SITES, ANTIBODY; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; FLOW CYTOMETRY; HUMANS; IMAGING, THREE-DIMENSIONAL; IMMUNODOMINANT EPITOPES; IMMUNOGLOBULIN FAB FRAGMENTS; IODIDE PEROXIDASE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; THYROID DISEASES; TRANSFECTION;

EID: 33751537659     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0912     Document Type: Article

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