(n-3) fatty acids reduce the release of prostaglandin E2 from bone but do not affect bone mass in obese (fa/fa) and lean Zucker rats

Journal of Nutrition

Volumn 135, Issue 3, 2005, Pages 499-504

  Mollard, Rebecca C ^a   Gillam, Melani E ^a   Wood, Trisha M ^a   Taylor, Carla G ^a   Weiler, Hope A ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Bone; Hyperinsulinemia; Obesity; PUFA; Type 2 diabetes mellitus

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; LINSEED OIL; MENHADEN OIL; OSTEOCALCIN; PROSTAGLANDIN E2; SAFFLOWER OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE MINERAL; CONFERENCE PAPER; CONTROLLED STUDY; DIAPHYSIS; DIET THERAPY; FAT INTAKE; FEMUR; FEMUR EPIPHYSIS; FEMUR HEAD; MALE; MORPHOMETRICS; NONHUMAN; OBESITY; PROSTAGLANDIN RELEASE; RAT; RAT STRAIN;

CARTHAMUS TINCTORIUS;

EID: 14944357328     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.3.499     Document Type: Conference Paper

References (71)

1. Willms, J. D., Tremblay, M. S. & Katzmarzyk, P. T. (2003) Geographic and demographic variation in the prevalence of overweight Canadian children. Obes. Res. 11: 668-673.
2. Barker, D. J. (1998) In utero programming of chronic disease. Clin. Sci. (Lond.) 95: 115-128.
3. Cruz, M. L. & Goran, M. I. (2004) The metabolic syndrome in children and adolescents. Curr. Diab. Rep. 4: 53-62.
4. Young, T. K., Martens, P. J., Taback, S. P., Sellers, E. A., Dean, H. J., Cheang, M. & Flett, B. (2002) Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians. Arch. Pediatr. Adolesc. Med. 156: 651-655.
5. Weiler, H. A., Janzen, L., Green, K., Grabowski, J., Seshia, M. M. & Yuen, K. C. (2000) Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age. Bone 27: 203-207.
6. Goulding, A., Jones, I. E., Taylor, R. W., Williams, S. M. & Manning, P. J. (2001) Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy X-ray absorptiometry study. J. Pediatr. 139: 509-515.
7. Goulding, A., Cannan, R., Williams, S. M., Gold, E. J., Taylor, R. W. & Lewis-Barned, N. J. (1998) Bone mineral density in girls with forearm fractures. J. Bone Miner. Res 13: 143-148.
8. Goulding, A., Jones, I. E., Taylor, R. W., Manning, P. J. & Williams, S. M. (2000) More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J. Bone Miner. Res. 15: 2011-2018.
9. Barrett-Connor, E. & Holbrook, T. L. (1992) Sex differences in osteoporosis in older adults with non-insulin-dependent diabetes mellitus. J. Am. Med. Assoc. 268: 3333-3337.
10. Bauer, D. C., Browner, W. S., Cauley, J. A., Orwoll, E. S., Scott, J. C., Black, D. M., Tao, J. L. & Cummings, S. R. (1993) Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Ann. Intern. Med. 118: 657-665.
11. Bouillon, R. (1991) Diabetic bone disease. Calcif. Tissue Int. 49: 155-160.
12. van Daele, P. L., Stolk, R. P., Burger, H., Algra, D., Grobbee, D. E., Hofman, A., Birkenhager, J. C. & Pols, H. A. (1995) Bone density in non-insulin-dependent diabetes mellitus. The Rotterdam Study. Ann. Intern. Med. 122: 409-414.
13. Isaia, G. C., Ardissone, P., Di Stefano, M., Ferrari, D., Martina, V., Porta, M., Tagliabue, M. & Molinatti, G. M. (1999) Bone metabolism in type 2 diabetes mellitus. Acta Diabetol. 36: 35-38.
14. Tenenhouse, A., Joseph, L., Kreiger, N., Poliquin, S., Murray, T. M., Blondeau, L., Berger, C., Hanley, D. A. & Prior, J. C. (2000) Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos. Int. 11: 897-904.
15. Berry, E. M. (1997) Dietary fatty acids in the management of diabetes mellitus. Am. J. Clin. Nutr. 66: 991S-997S.
16. Das, U. N. (2000) Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how? Prostaglandins Leukot. Essent. Fatty Acids 63: 351-362.
17. Green, K. H., Wong, S. C. & Weiler, H. A. (2004) The effect of dietary n-3 long-chain polyunsaturated fatty acids on femur mineral density and biomarkers of bone metabolism in healthy, diabetic and dietary-restricted growing rats. Prostaglandins Leukot. Essent. Fatty Acids 71: 121-130.
18. Watkins, B., Yong, L., Allen, K., Hoffmann, W. & Seifert, M. (2000) Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats. J. Nutr. 130: 2274-2284.
19. 2 biosynthesis, tissue IGF-1 levels, and bone morphometry in chicks. J. Bone Miner. Res. 11: 1321-1332.
20. Alam, S., Kokkinos, P. & Alam, B. (1993) Fatty acid composition and arachidonic acid concentrations in alveolar bone of rats fed diets with different lipids. Calcif. Tissue Int. 53: 330-332.
21. 2 production, insulin-like growth factor-1 concentration and formation rate in chicks. J. Nutr. 127: 1084-1091.
22. Weiler, H. (2000) Dietary supplementation of arachidonic acid is associated with higher whole body weight and bone mineral density in growing pigs. Pediatr. Res. 47: 692-697.
23. Raisz, L. G. (1999) Prostaglandins and bone: physiology and pathophysiology. Osteoarthritis Cartilage 7: 419-421.
24. 3 and eicosapentaenoic acid on rat bone in organ culture. Prostaglandins 37: 615-625.
25. Zucker, L. M. & Antoniades, H. N. (1972) Insulin and obesity in the Zucker genetically obese rat "fatty." Endocrinology 90: 1320-1330.
26. Bryce, G. F., Johnson, P. R., Sullivan, A. C. & Stern, J. S. (1977) Insulin and glucagon: plasma levels and pancreatic release in the genetically obese Zucker rat. Horm. Metab. Res. 9: 366-370.
27. Muller, S. & Cleary, M. P. (1988) Glucose metabolism in isolated adipocytes from ad libitum- and restricted-fed lean and obese Zucker rats at two different ages. Proc. Soc. Exp. Biol. Med. 187: 398-407.
28. Zucker, L. & Zucker, T. (1961) Fatty, a new mutation in the rat. J. Hered. 52: 275-278.
29. Tamasi, J. A., Arey, B. J., Bertolini, D. R. & Feyen, J. H. (2003) Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats. J. Bone Miner. Res. 18: 1605-1611.
30. Foldes, J., Shih, M. S. & Levy, J. (1992) Bone structure and calcium metabolism in obese Zucker rats. Int. J. Obes. Relat. Metab. Disord. 16: 95-102.
31. Picherit, C., Horcajada, M. N., Mathey, J., Chanteranne, B., Puel, C., Lebecque, P., Davicco, M. J., Coxam, V. & Barlet, J. P. (2003) Isoflavone consumption does not increase the bone mass in osteopenic obese female Zucker rats. Ann. Nutr. Metab. 47: 70-77.
32. Lee, J. H., Ikeda, I. & Sugano, M. (1992) Effects of dietary n-6/n-3 polyunsaturated fatty acid balance on tissue lipid levels, fatty acid patterns, and eicosanoid production in rats. Nutrition 8: 162-166.
33. Reeves, P. G. (1997) Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 127: 838S-841S.
34. Tallman, D. L. & Taylor, C. G. (2003) Effects of dietary fat and zinc on adiposity, serum leptin and adipose fatty acid composition in C57BL/6J mice. J. Nutr. Biochem. 14: 17-23.
35. Canadian Council on Animal Care (1993) Guide to the Care and Use of Experimental Animals, 2nd ed. Bradda Printing Services, Ottawa, Canada.
36. Reichling, T. D. & German, R. Z. (2000) Bones, muscles and visceral organs of protein-malnourished rats (Rattus norvegicus) grow more slowly but for longer durations to reach normal final size. J. Nutr. 130: 2326-2332.
37. Kastl, S., Sommer, T., Klein, P., Hohenberger, W. & Engelke, K. (2002) Accuracy and precision of bone mineral density and bone mineral content in excised rat humerl using fan beam dual-energy X-ray absorptiometry. Bone 30: 243-246.
38. Clegg, M., Kenn, C., Lonnerdal, B. & Hurley, L. (1981) Influence of ashing techniques on the analysis of trace elements in animal tissues. I. Wet ashing. Biol. Trace Elem. Res. 3: 107-115.
39. Dekel, S., Lenthall, G. & Francis, M. J. (1981) Release of prostaglandins from bone and muscle after tibial fracture. An experimental study in rabbits. J. Bone Joint Surg. B. 63-B: 185-189.
40. Manzoni, P., Brambilla, P., Pietrobelli, A, Beccaria, L., Bianchessi, A., Mora, S. & Chiumello, G. (1996) Influence of body composition on bone mineral content in children and adolescents. Am. J. Clin. Nutr. 64: 603-607.
41. Ellis, K. J., Shypailo, R. J., Wong, W. W. & Abrams, S. A. (2003) Bone mineral mass in overweight and obese children: diminished or enhanced? Acta Diabetol. 40 (suppl. 1): S274-S277.
42. Klein, K. O., Larmore, K. A., de Lancey, E., Brown, J. M., Considine, R. V. & Hassink, S. G. (1998) Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J. Clin. Endocrinol. Metab. 83: 3469-3475.
43. Yamada, Y., Mizuno, K., Kotani, H. & Otsuji, K. (1997) A survey regarding the factors that influence bone mineral density among female high school students. J. Med. 28: 393-404.
44. Specker, B. L., Johannsen, N., Binkley, T. & Finn, K. (2001) Total body bone mineral content and tibial cortical bone measures in preschool children. J. Bone Miner. Res. 16: 2298-2305.
45. Goulding, A., Taylor, R. W., Jones, I. E., McAuley, K. A., Manning, P. J. & Williams, S. M. (2000) Overweight and obese children have low bone mass and area for their weight. Int. J. Obes. Relat. Metab. Disord. 24: 627-632.
46. Goulding, A, Taylor, R. W., Jones, I. E., Manning, P. J. & Williams, S. M. (2002) Spinal overload: a concern for obese children and adolescents? Osteoporos. Int. 13: 835-840.
47. Goulding, A., Jones, I.E., Taylor, R. W., Piggot, J. M. & Taylor, D. (2003) Dynamic and static tests of balance and postural sway in boys: effects of previous wrist bone fractures and high adiposity. Gait Posture 17: 136-141.
48. Mathey, J., Horcajada-Molteni, M. N., Chanteranne, B., Picherit, C., Puel, C., Lebecque, P., Cubizoles, C., Davicco, M. J., Coxam, V. & Barlet, J. P. (2002) Bone mass in obese diabetic Zucker rats: influence of treadmill running. Calcif. Tissue Int. 70: 305-311.
49. Forsen, L., Meyer, H. E., Midthjell, K. & Edna, T. H. (1999) Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag Health Survey. Diabetologia 42: 920-925.
50. Tuominen, J. T., Impivaara, O., Puukka, P. & Ronnemaa, T. (1999) Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care 22: 1196-1200.
51. Hampson, G., Evans, C., Petitt, R. J., Evans, W. D., Woodhead, S. J., Peters, J. R. & Ralston, S. H. (1998) Bone mineral density, collagen type 1 alpha 1 genotypes and bone turnover in premenopausal women with diabetes mellitus. Diabetologia 41: 1314-1320.
52. Christensen, J. O. & Svendsen, O. L. (1999) Bone mineral in pre-and postmenopausal women with insulin-dependent and non-insulin-dependent diabetes mellitus. Osteoporos. Int. 10: 307-311.
53. Wakasugi, M., Wakao, R., Tawata, M., Gan, N., Koizumi, K. & Onaya, T. (1993) Bone mineral density measured by dual energy X-ray absorptiometry In patients with non-insulin-dependent diabetes mellitus. Bone 14: 29-33.
54. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. J. Am. Med. Assoc. 285: 785-795.
55. Reid, I. R., Evans, M. G., Cooper, G. J., Ames, R. W. & Stapleton, J. (1993) Circulating insulin levels are related to bone density in normal postmenopausal women. Am. J. Physiol. 265: E655-E659.
56. Smythe, H. A. (1987) Osteoarthritis, insulin and bone density. J. Rheumatol. 14 (spec. no): 91-93.
57. Pietschmann, P., Schernthaner, G. & Woloszczuk, W. (1988) Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications. Diabetologia 31: 892-895.
58. Rico, H., Hernandez, E. R., Cabranes, J. A. & Gomez-Castresana, F. (1989) Suggestion of a deficient osteoblastic function in diabetes mellitus: the possible cause of osteopenia in diabetics. Calcif. Tissue Int. 45: 71-73.
59. Inaba, M., Nishizawa, Y., Mita, K., Kumeda, Y., Emoto, M., Kawagishi, T., Ishimura, E., Nakatsuka, K., Shioi, A. & Morii, H. (1999) Poor glycemic control impairs the response of biochemical parameters of bone formation and resorption to exogenous 1,25-dihydroxyvitamin D3 in patients with type 2 diabetes. Osteoporos. Int. 9: 525-531.
60. Kao, C. H., Tsou, C. T., Chen, C. C. & Wang, S. J. (1993) Bone mineral density in patients with noninsulin-dependent diabetes mellitus by dual photon absorptiometry. Nucl. Med. Commun. 14: 373-377.
61. Abrahamsen, B., Rohold, A., Henriksen, J. E. & Beck-Nielsen, H. (2000) Correlations between insulin sensitivity and bone mineral density in non-diabetic men. Diabetic Med. 17: 124-129.
62. Gregorio, F., Cristallini, S., Santeusanio, F., Filipponi, P. & Fumelli, P. (1994) Osteopenia associated with non-insulin-dependent diabetes mellitus: what are the causes? Diabetes Res. Clin. Pract. 23: 43-54.
63. Weiler, H. A. & Fitzpatrick-Wong, S. C. (2002) Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. J. Nutr. 132: 2667-2672.
64. Weiler, H. A. & Fitzpatrick-Wong, S. (2002) Dietary long-chain polyunsaturated fatty acids minimize dexamethasone-induced reductions in arachidonic acid status but not bone mineral content in piglets. Pediatr. Res. 51: 282-289.
65. Blanaru, J. L., Kohut, J. R., Fitzpatrick-Wong, S. C. & Weiler, H. A. (2004) Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula. Am. J. Clin. Nutr. 79: 139-147.
66. Lucia, V. D., Fitzpatrick-Wong, S. C. & Weiler, H. A. (2003) Dietary arachidonic acid suppresses bone turnover in contrast to low dosage exogenous prostaglandin E(2) that elevates bone formation in the piglet. Prostaglandins Leukot. Essent. Fatty Acids 68: 407-413.
67. Claassen, N., Potgieter, H., Seppa, M., Vermaak, W., Coetzer, H., Van Papendorp, D. & Kruger, M. (1995) Supplemented gamma-linolenic acid and eicosapentaenoic acid influence bone status in young male rats: effects on free urinary collagen crosslinks, total urinary hydroxyproline, and bone calcium content. Bone 16: 385S-392S.
68. Bassey, E. J., Littlewood, J. J., Rothwell, M. C. & Pye, D. W. (2000) Lack of effect of supplementation with essential fatty acids on bone mineral density in healthy pre- and postmenopausal women: two randomized controlled trials of Efacal v. calcium alone. Br. J. Nutr. 83: 629-635.
69. Sun, D., Krishnan, A., Zaman, K., Lawrence, R., Bhattacharya, A. & Fernandes, G. (2003) Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J. Bone Miner. Res. 18: 1206-1216.
70. Schlemmer, C. K., Coetzer, H., Claassen, N. & Kruger, M. C. (1999) Oestrogen and essential fatty acid supplementation corrects bone loss due to ovariectomy in the female Sprague Dawley rat. Prostaglandins Leukot. Essent. Fatty Acids 61: 381-390.
71. Kruger, M. C., Coetzer, H., de Winter, R., Gericke, G. & van Papendorp, D. H. (1998) Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile Osteoporosis. Aging 10: 385-394.