Does simvastatin stimulate bone formation in vivo?

BMC Musculoskeletal Disorders

Volumn 4, Issue , 2003, Pages 1-10

  Von Stechow, Dietrich ^a   Fish, Susan ^a   Yahalom, Dror ^a   Bab, Itai ^a,b   Chorev, Michael ^a   Müller, Ralph ^c   Alexander, Joseph M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; OSTEOCALCIN; PARATHYROID HORMONE; SIMVASTATIN; SIMVASTATIN BETA HYDROXY ACID; UNCLASSIFIED DRUG; DRUG DERIVATIVE; SIMVASTATIN ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DRUG DETERMINATION; FEMALE; FEMUR; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOPENIA; OVARIECTOMY; PROTEIN BLOOD LEVEL; TRABECULAR BONE; ANIMAL; BLOOD; COMPARATIVE STUDY; DIGESTIVE TRACT INTUBATION; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; METHODOLOGY; OSTEOLYSIS; OVARY; PHYSIOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BONE RESORPTION; DRUG ADMINISTRATION ROUTES; FEMALE; FEMUR; INJECTIONS, SUBCUTANEOUS; INTUBATION, GASTROINTESTINAL; MICE; OSTEOCALCIN; OSTEOGENESIS; OVARIECTOMY; OVARY; PARATHYROID HORMONE; SIMVASTATIN;

EID: 0038826568     PISSN: 14712474     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-4-8     Document Type: Article

References (34)

1. Banu J and Kalu DN Effects of cerivastatin and parathyroid hormone on the lumbar vertebra of aging male Sprague-Dawley rats Bone 2002, 31:173-179
2. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M and Gutierrez G Stimulation of bone formation in vitro and in rodents by statins Science 1999, 286:1946-1949
3. Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B and Jick H HMG-CoA reductase inhibitors and the risk of fractures Jama 2000, 283:3205-3210
4. Oxlund H, Dalstra M and Andreassen TT Statin given perorally to adult rats increases cancellous bone mass and compressive strength Calcif Tissue Int 2001, 69:299-304
5. Skoglund B, Forslund C and Aspenberg P Simvastatin improves fracture healing in mice J Bone Miner Res 2002, 17:2004-2008
6. Whang K, Zhao M, Qaio M, Rossini G, Horn D, Garrett IR, Mundy GR and Chen D Administration of lovastatin locally in low doses in a novel; delivery system induces prolonged bone formation J Bone Miner Res 2000, 15(Suppl):S225
7. Cummings SR and Bauer DC Do statins prevent both cardiovascular disease and fracture? Jama 2000, 283:3255-3257
8. Schneider EL and Guralnik JM The aging of America. Impact on health care costs Jama 1990, 263:2335-2340
9. Looker AC, Johnston CC Jr, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP and Lindsay RL Prevalence of low femoral bone density in older U.S. women from NHANES III J Bone Miner Res 1995, 10:796-802
10. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O and Mitlak BH Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis N Engl J Med 2001, 344:1434-1441
11. Alexander JM, Bab I, Fish S, Müller R, Uchiyama T, Gronowicz G, Nahounou M, Zhao Q, White DW, Chorev M, Gazit D and Rosenblatt M Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice J Bone Miner Res 2001, 16:1665-1673
12. Rüegsegger P, Koller B and Müller R A microtomographic system for the nondestructive evaluation of bone architecture Calcif Tissue Int 1996, 58:24-29
13. Müller R and Rüegsegger P Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture Stud Health Technol Inform 1997, 40:61-79
14. Hildebrand T, Laib A, Müller R, Dequeker J and Rüegsegger P Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus J Bone Miner Res 1999, 14:1167-1174
15. Wu Y, Zhao J, Henion J, Korfmacher WA, Lapiguera AP and Lin CC Microsample determination of lovastatin and its hydroxy acid metabolite in mouse and rat plasma by liquid chromatography/ionspray tandem mass spectrometry J Mass Spectrom 1997, 32:379-387
16. Conover WJ Practical nonparametric statistics New York: John Wiley 1999,
17. Armitage P and Berry G Statistical methods in medical research Cambridge, MA: Blackwell Science 1994,
18. Vickers S, Duncan CA, Chen IW, Rosegay A and Duggan DE Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug Drug Metabolism and Disposition 1990, 18:138-145
19. Istvan ES and Deisenhofer J Structural mechanism for statin inhibition of HMG-CoA reductase Science 2001, 292:1160-1164
20. Altieri DC Statins' benefits begin to sprout J Clin Invest 2001, 108:365-366
21. Rao S, Porter DC, Chen X, Herliczek T, Lowe M and Keyomarsi K Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase Proc Natl Acad Sci U S A 1999, 96:7797-7802
22. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC and Walsh K The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 2000, 6:1004-1010
23. Davignon J and Laaksonen R Low-density lipoprotein-independent effects of statins Curr Opin Lipidol 1999, 10:543-559
24. Corsini A, Maggi FM and Catapano AL Pharmacology of competitive inhibitors of HMG-CoA reductase Pharmacol Res 1995, 31:9-27
25. Yao W, Li CY, Farmer RW, Chen JL, Mo A, Cooper R, Chmielewski P, Setterberg RB, Jee WSS and Lundy MW Simvastatin did not prevent bone loss in ovariectomized rats J Bone Miner Res 2001, 16:S294
26. Gasser JA Fluvastatin and cervastatin are not anabolic for bone after local and systemic administration of non-toxic doses in mice and rats J Bone Miner Res 2001, 16:S295
27. Crawford DT, Qi H, Chidesy-Frink KL, Thompson DD and Ke HZ Statin increases cortical bone in young male rats by single, local administration but fails to restore bone in ovariectomized (OVX) rats by daily systemic administration J Bone Miner Res 2001, 16:S295
28. Baumann AP, Grasser W, Petras S, Harwood HJ, Thompson DD and Paralkar V Inhibition of osteoclast formation by statins J Bone Miner Res 2001, 16:S507
29. Chan KA, Andrade SE, Boles M, Buist DS, Chase GA, Donahue JG, Goodman MJ, Gurwitz JH, LaCroix AZ and Platt R Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women Lancet 2000, 355:2185-2188
30. Wang PS, Solomon DH, Mogun H and Avorn J HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients Jama 2000, 283:3211-3216
31. LaCroix AZ, Cauley JA, Jackson R, McGowan J, Pettinger M, Hsia J, Chen Z, Lewis C, Bauer DC, Daugherty S, McNeeley SG and Passaro M Does statin use reduce the risk of fracture in postmenopausal women? Results from the Women's Health Initiative Observational Study (WHIOS) J Bone Miner Res 2000, 15(Suppl):S155
32. van Staa TP, Wegman SLJ, F. dV, Leufkens HGM and Cooper C Use of Statins and risk of fracture J Bone Miner Res 2000, 16(Suppl):S155
33. Oxlund H Simvastatin given perorally increases the cortical bone formation rate in adult rats J Bone Miner Res 1999, 15(Suppl):S313
34. Garrett IR, Esparza J, Chen D, Zhao M, Guiterrez G, Escobedo A, Horn D and Mundy GR Statins mediate their effects on osteoblasts by inhibition of HMG-CoA reductase and ultimately BMP-2 J Bone Miner Res 2000, 15(Suppl):