-
1
-
-
32144454172
-
The many roles of chemokine and chemokine receptors in inflammation
-
Charo I.F., and Ransahoff R.M. The many roles of chemokine and chemokine receptors in inflammation. NEJM 354 (2006) 610-621
-
(2006)
NEJM
, vol.354
, pp. 610-621
-
-
Charo, I.F.1
Ransahoff, R.M.2
-
2
-
-
30344488431
-
Chemokine blockers - therapeutics in the making?
-
Wells T.N.C., et al. Chemokine blockers - therapeutics in the making?. Trends Pharmacol. Sci. 27 (2006) 41-47
-
(2006)
Trends Pharmacol. Sci.
, vol.27
, pp. 41-47
-
-
Wells, T.N.C.1
-
3
-
-
33644865904
-
Early development of therapeutic biologics-pharmacokinetics
-
Baumann A. Early development of therapeutic biologics-pharmacokinetics. Curr. Drug Metab. 7 (2006) 15-21
-
(2006)
Curr. Drug Metab.
, vol.7
, pp. 15-21
-
-
Baumann, A.1
-
4
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
-
Redfern W.S., et al. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58 (2003) 32-45
-
(2003)
Cardiovasc. Res.
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
-
5
-
-
0037299567
-
Knock out models to dissect chemokine receptor function in vivo
-
Power C.A. Knock out models to dissect chemokine receptor function in vivo. J. Immunol. Methods 273 (2003) 73-82
-
(2003)
J. Immunol. Methods
, vol.273
, pp. 73-82
-
-
Power, C.A.1
-
6
-
-
0034947236
-
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis
-
Peters W., et al. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. 98 (2001) 7958-7963
-
(2001)
Proc. Natl. Acad. Sci.
, vol.98
, pp. 7958-7963
-
-
Peters, W.1
-
7
-
-
0035576223
-
CXCR2 deficiency confers imparied neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection
-
Del Rio L., et al. CXCR2 deficiency confers imparied neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. J. Immunol. 167 (2001) 6503-6509
-
(2001)
J. Immunol.
, vol.167
, pp. 6503-6509
-
-
Del Rio, L.1
-
8
-
-
13444283754
-
CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi
-
Machado F.S., et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J. Infect. Dis. 191 (2005) 627-636
-
(2005)
J. Infect. Dis.
, vol.191
, pp. 627-636
-
-
Machado, F.S.1
-
9
-
-
0031726770
-
Inhibition of neutrophil-mediated actute inflammatory injury by an antibody against interleukin-8 (IL-8)
-
Muikaida N., et al. Inhibition of neutrophil-mediated actute inflammatory injury by an antibody against interleukin-8 (IL-8). Inflamm. Res. 47 (1998) s151-s157
-
(1998)
Inflamm. Res.
, vol.47
-
-
Muikaida, N.1
-
10
-
-
0030048179
-
Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease
-
Nocker R.E., et al. Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease. Int. Arch. Allergy Immunol. 109 (1996) 183-191
-
(1996)
Int. Arch. Allergy Immunol.
, vol.109
, pp. 183-191
-
-
Nocker, R.E.1
-
11
-
-
0029943773
-
Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma
-
Wang N., et al. Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J. Biol. Chem. 271 (1996) 8837-8842
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8837-8842
-
-
Wang, N.1
-
12
-
-
0036310021
-
Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma
-
Huang S., et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am. J. Pathol. 161 (2002) 125-134
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 125-134
-
-
Huang, S.1
-
13
-
-
0037573025
-
ABX-IL8 in the treatment of psoriasis: clinical results
-
Abstract 188
-
Horowitz M.H., and Krueger G.G. ABX-IL8 in the treatment of psoriasis: clinical results. Society Invest. Derm. 119 (2002) Abstract 188
-
(2002)
Society Invest. Derm.
, vol.119
-
-
Horowitz, M.H.1
Krueger, G.G.2
-
14
-
-
0034144269
-
Chemokines: a new classification system and their role in immunity
-
Zlotnik A., and Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 12 (2000) 121-127
-
(2000)
Immunity
, vol.12
, pp. 121-127
-
-
Zlotnik, A.1
Yoshie, O.2
-
15
-
-
21544448584
-
Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody
-
Lutgens E., et al. Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. Circulation 111 (2005) 3443-3452
-
(2005)
Circulation
, vol.111
, pp. 3443-3452
-
-
Lutgens, E.1
-
16
-
-
31044456061
-
Diet induction of monocyte chemoattractant protein-1 and its impact on obesity
-
Chen A., et al. Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes. Res. 13 (2005) 1311-1320
-
(2005)
Obes. Res.
, vol.13
, pp. 1311-1320
-
-
Chen, A.1
-
17
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg S.P., et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Invest. 116 (2006) 115-124
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.1
-
18
-
-
0030909913
-
The role of monocyte chemoattractant protein-1 in the pathogenesis of collagen-induced arthritis in rats
-
Ogata H., et al. The role of monocyte chemoattractant protein-1 in the pathogenesis of collagen-induced arthritis in rats. J. Pathol. 182 (1997) 106-114
-
(1997)
J. Pathol.
, vol.182
, pp. 106-114
-
-
Ogata, H.1
-
19
-
-
26844448558
-
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344
-
Brodmerkel C.M., et al. Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J. Immunol. 15 (2005) 5370-5378
-
(2005)
J. Immunol.
, vol.15
, pp. 5370-5378
-
-
Brodmerkel, C.M.1
-
20
-
-
33746805021
-
The role of CCL12 in the recruitment of fibrocytes and lung fibrosis
-
10.1165/rcmb.2005-023900
-
Moore B.B., et al. The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am. J. Respir. Cell Mol. Biol. (2006). http://www.ajrcmb.org/ 10.1165/rcmb.2005-023900
-
(2006)
Am. J. Respir. Cell Mol. Biol.
-
-
Moore, B.B.1
-
21
-
-
30944441131
-
Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists
-
Anders H.J., et al. Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int. 69 (2006) 29-32
-
(2006)
Kidney Int.
, vol.69
, pp. 29-32
-
-
Anders, H.J.1
-
22
-
-
0033987396
-
Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic allograft rejection
-
Gao W., et al. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic allograft rejection. J. Clin. Invest. 105 (2000) 35-44
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 35-44
-
-
Gao, W.1
-
23
-
-
26844562398
-
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis
-
Revesz L., et al. Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg. Med. Chem. Lett. 15 (2005) 5160-5164
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 5160-5164
-
-
Revesz, L.1
-
24
-
-
22744448476
-
CCR1 antagonists in clinical development
-
Pease J.E., and Horuk R. CCR1 antagonists in clinical development. Exp. Opin. Investig. Drugs 14 (2005) 785-796
-
(2005)
Exp. Opin. Investig. Drugs
, vol.14
, pp. 785-796
-
-
Pease, J.E.1
Horuk, R.2
-
25
-
-
32044458204
-
Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection
-
Miller A.L., et al. Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection. J. Immunol. 176 (2006) 2562-2567
-
(2006)
J. Immunol.
, vol.176
, pp. 2562-2567
-
-
Miller, A.L.1
-
26
-
-
0028809554
-
Molecular characterization of two murine eosinophil beta chemokine receptors
-
Post T.W., et al. Molecular characterization of two murine eosinophil beta chemokine receptors. J. Immunol. 155 (1995) 5299-5305
-
(1995)
J. Immunol.
, vol.155
, pp. 5299-5305
-
-
Post, T.W.1
-
27
-
-
0030601109
-
Identification of a mouse eosinophil receptor for the CC chemokine eotaxin
-
Gao J.L., et al. Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem. Biophys. Res. Commun. 223 (1996) 679-684
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.223
, pp. 679-684
-
-
Gao, J.L.1
-
28
-
-
0029060674
-
Cloning and functional expression of a human eosinophil CC chemokine receptor
-
Combadiere C., Ahuja S.K., and Murphy P.M. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270 (1996) 16491-16494
-
(1996)
J. Biol. Chem.
, vol.270
, pp. 16491-16494
-
-
Combadiere, C.1
Ahuja, S.K.2
Murphy, P.M.3
-
29
-
-
33644883892
-
Asthma, allergy, and chemokines
-
Pease J.E. Asthma, allergy, and chemokines. Curr. Drug Targets 7 (2006) 3-12
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 3-12
-
-
Pease, J.E.1
-
30
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response
-
Leckie M.J., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 356 (2000) 2144-2148
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
-
31
-
-
0037438409
-
Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthamatic airway
-
Flood-Page P.T., et al. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthamatic airway. Am. J. Respir. Crit. Care Med. 167 (2003) 199-204
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 199-204
-
-
Flood-Page, P.T.1
-
32
-
-
31044441420
-
Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction
-
Fryer A.D., et al. Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. J. Clin. Invest. 116 (2006) 228-236
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 228-236
-
-
Fryer, A.D.1
-
33
-
-
33645130724
-
A novel, selective, and orally available antagonist for CC chemokine receptor 3
-
Morokata T., et al. A novel, selective, and orally available antagonist for CC chemokine receptor 3. J. Pharmacol. Exp. Ther. 317 (2006) 244-250
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.317
, pp. 244-250
-
-
Morokata, T.1
-
34
-
-
29044439351
-
In Vitro and in vivo characterization of a novel CCR3 anatagonist, YM-344031
-
Suzuki K., et al. In Vitro and in vivo characterization of a novel CCR3 anatagonist, YM-344031. Biochem. Biophys. Res. Commun. 339 (2006) 1217-1223
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.339
, pp. 1217-1223
-
-
Suzuki, K.1
-
35
-
-
2442495483
-
Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum
-
Dent G., et al. Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum. Am. J. Respir. Crit. Care Med. 169 (2004) 1110-1117
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.169
, pp. 1110-1117
-
-
Dent, G.1
-
36
-
-
33751170121
-
Identification of a major co-receptor for priamry isolates of HIV-1
-
Deng H., et al. Identification of a major co-receptor for priamry isolates of HIV-1. Nature 381 (1996) 647-648
-
(1996)
Nature
, vol.381
, pp. 647-648
-
-
Deng, H.1
-
37
-
-
15844388931
-
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
-
Liu R., et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86 (1996) 367-377
-
(1996)
Cell
, vol.86
, pp. 367-377
-
-
Liu, R.1
-
38
-
-
13444303844
-
Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular wieght antagonist of CCR5
-
Vierboom M.P., et al. Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular wieght antagonist of CCR5. Arthritis Rheum. 52 (2005) 627-636
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 627-636
-
-
Vierboom, M.P.1
-
39
-
-
0035886302
-
Beneficial effects of targeting CCR5 in allograft recipients
-
Gao W., et al. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 72 (2005) 1199-1205
-
(2005)
Transplantation
, vol.72
, pp. 1199-1205
-
-
Gao, W.1
-
40
-
-
33750337778
-
Characterization of novel human monoclonal antibodies that specifically antagonize CCR5 and block HIV-1 entry
-
(Abstract 2871)
-
Roschke V., et al. Characterization of novel human monoclonal antibodies that specifically antagonize CCR5 and block HIV-1 entry. 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) (2005) (Abstract 2871)
-
(2005)
44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
-
-
Roschke, V.1
-
41
-
-
27144517061
-
CXC chemokines in angiogenesis
-
Strieter R.M., et al. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev. 16 (2005) 593-609
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 593-609
-
-
Strieter, R.M.1
-
42
-
-
28444466925
-
CXCR3-mediated opposite effects of CXCL10 and CXCL4 on Th1 or Th2 cytokine production
-
Romagnani P., et al. CXCR3-mediated opposite effects of CXCL10 and CXCL4 on Th1 or Th2 cytokine production. J. Allergy Clin. Immunol. 116 (2005) 1372-1379
-
(2005)
J. Allergy Clin. Immunol.
, vol.116
, pp. 1372-1379
-
-
Romagnani, P.1
-
43
-
-
33645414100
-
HIV-1 coreceptors and their inhibitors
-
Ray N., and Doms R.W. HIV-1 coreceptors and their inhibitors. Curr. Top Microbiol. Immunol. 303 (2006) 97-120
-
(2006)
Curr. Top Microbiol. Immunol.
, vol.303
, pp. 97-120
-
-
Ray, N.1
Doms, R.W.2
-
44
-
-
33644920656
-
Lymphoproliferative disorders and chemokines
-
Pistoia V., et al. Lymphoproliferative disorders and chemokines. Curr. Drug Targets 7 (2006) 81-90
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 81-90
-
-
Pistoia, V.1
-
45
-
-
0034544508
-
Stromal-cell derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis
-
Nanki T., et al. Stromal-cell derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis. J. Immunol. 165 (2000) 6590-6598
-
(2000)
J. Immunol.
, vol.165
, pp. 6590-6598
-
-
Nanki, T.1
-
46
-
-
33646444336
-
New strategies for mobilization of hematopoietic stem cells
-
Fruehauf S., and Seeger T. New strategies for mobilization of hematopoietic stem cells. Future Oncol. 1 (2005) 375-383
-
(2005)
Future Oncol.
, vol.1
, pp. 375-383
-
-
Fruehauf, S.1
Seeger, T.2
-
47
-
-
13844311525
-
The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor
-
Pelus L.M., et al. The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor. Exp. Hematol. 33 (2005) 295-307
-
(2005)
Exp. Hematol.
, vol.33
, pp. 295-307
-
-
Pelus, L.M.1
-
48
-
-
0344823964
-
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
-
Rubin J.B., et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. PNAS 100 (2003) 13513-13518
-
(2003)
PNAS
, vol.100
, pp. 13513-13518
-
-
Rubin, J.B.1
-
49
-
-
13444265875
-
Silencing of CXCR4 blocks breast cancer metastasis
-
Liang Z., et al. Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res. 65 (2005) 967-971
-
(2005)
Cancer Res.
, vol.65
, pp. 967-971
-
-
Liang, Z.1
-
50
-
-
3042593906
-
Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent
-
Tamamura H. Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. FEBS Lett 569 (2004) 99-104
-
(2004)
FEBS Lett
, vol.569
, pp. 99-104
-
-
Tamamura, H.1
-
51
-
-
33644677814
-
Pro-inflammatorry properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis
-
De Klerck B. Pro-inflammatorry properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis. Arthritis Res. Ther. 7 (2005) R1208-R1220
-
(2005)
Arthritis Res. Ther.
, vol.7
-
-
De Klerck, B.1
-
52
-
-
0032507962
-
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
-
Zou Y.-R., et al. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393 (1998) 595-599
-
(1998)
Nature
, vol.393
, pp. 595-599
-
-
Zou, Y.-R.1
-
53
-
-
0029758113
-
Defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
-
Nagasawa T., et al. Defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382 (1996) 635-638
-
(1996)
Nature
, vol.382
, pp. 635-638
-
-
Nagasawa, T.1
-
54
-
-
11844294973
-
CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangocyte and hepatocytes within the inflamed human liver
-
Heydtmann M., et al. CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangocyte and hepatocytes within the inflamed human liver. J. Immunol. 174 (2005) 1055-1062
-
(2005)
J. Immunol.
, vol.174
, pp. 1055-1062
-
-
Heydtmann, M.1
-
55
-
-
0035908021
-
Aberrant high expression of B lymphocyte chemokine (BLC/CXC:13) by C11b+CX11c+ deneritic cells in murine lupus and preferential chemotaxis of B1 cell toward BLC
-
Ishikawa S., et al. Aberrant high expression of B lymphocyte chemokine (BLC/CXC:13) by C11b+CX11c+ deneritic cells in murine lupus and preferential chemotaxis of B1 cell toward BLC. J. Exp. Med. 193 (2001) 1393-1402
-
(2001)
J. Exp. Med.
, vol.193
, pp. 1393-1402
-
-
Ishikawa, S.1
-
56
-
-
33646362290
-
B-cell targeting in rheumatoid arthritis and other autoimmune diseases
-
Cambridge G., and Edwards J.C. B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat. Rev. Immunol. 6 (2006) 394-403
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 394-403
-
-
Cambridge, G.1
Edwards, J.C.2
-
57
-
-
33644525606
-
The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice
-
Gladue R.P., et al. The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice. J. Immunol. 176 (2006) 3141-3148
-
(2006)
J. Immunol.
, vol.176
, pp. 3141-3148
-
-
Gladue, R.P.1
-
58
-
-
9144248460
-
Bertilimumab Cambridge Antibody Technology Group
-
Ding, et al. Bertilimumab Cambridge Antibody Technology Group. Curr. Opin. Investig. Drugs 5 (2004) 1213-1218
-
(2004)
Curr. Opin. Investig. Drugs
, vol.5
, pp. 1213-1218
-
-
Ding1
|