YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/ reoxygenation-induced SH-SY5Y neuronal cell damage

Molecular Pharmacology

Volumn 70, Issue 6, 2006, Pages 2075-2083

  Iwamoto, Takahiro ^a   Kita, Satomi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2 [4 (4 NITROBENZYLOXY)BENZYL]THIAZOLIDINE 4 CARBOXYLIC ACID ETHYL ESTER; ESTER DERIVATIVE; ION TRANSPORT AFFECTING AGENT; N (3 AMINOBENZYL)6 [4 [(3 FLUOROBENZYL)OXY]PHENOXY]NICOTINAMIDE; SN 6; UNCLASSIFIED DRUG; YM 244769;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CHIMERA; DRUG EFFECT; DRUG MECHANISM; DRUG SENSITIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYPOXIA; IC 50; MUTAGENESIS; MUTATIONAL ANALYSIS; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; REOXYGENATION;

ANIMALS; BASE SEQUENCE; CELL HYPOXIA; CELL LINE; CELL LINE, TUMOR; CRICETINAE; DNA PRIMERS; HUMANS; NEURONS; NIACINAMIDE; REPERFUSION INJURY; SODIUM-CALCIUM EXCHANGER;

EID: 33751086460     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.028464     Document Type: Article

References (40)

1. 2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol Rev 56:633-654.
2. Blaustein MP and Lederer WJ (1999) Sodium/calcium exchange: its physiological implications. Physiol Rev 79:763-854.
3. 2+ exchangers with altered ionic regulation. Mol Pharmacol 65:802-810.
4. 2+ exchanger. J Biol Chem 273:778-783.
5. 2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences. Am J Physiol 281:H1334-H1345.
6. Hilgemann DW, Collins A, and Matsuoka S (1992a) Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP. J Gen Physiol 100:933-961.
7. Hilgemann DW, Matsuoka S, Nagel GA, and Collins A (1992b) Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J Gen Physiol 100:905-932.
8. Iwamoto T (2005) Sodium-calcium exchange inhibitors: therapeutic potential in cardiovascular diseases. Future Cardiol 1:519-529.
9. 2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl] thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol Pharmacol 66:45-55.
10. 2+ exchange (NCX1) inhibition by SEA0400. J Biol Chem 279:7544-7553.
11. 2+ exchanger. Mol Pharmacol 59:524-531.
12. 2+ exchanger type-1 in vascular smooth muscle. Nat Med 10:1193-1199.
13. 2+ exchanger isoforms NCX1 and NCX3 does not require their direct phosphorylation. Biochemistry 37:17230-17238.
14. 2+ exchanger isoforms by divalent cations and isothiourea derivative. Am J Physiol 275:C423-C430.
15. 2+ affinity. J Biol Chem 275:38571-38580.
16. 2+ exchange in cells expressing NCX1. J Biol Chem 271:22391-22397.
17. 2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes. Br J Pharmacol 128:969-974.
18. Kuramochi T, Kakefuda A, Sato I, Tsukamoto I, Taguchi T, and Sakamoto S (2005a) Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl) oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study. Bioorg Med Chem 13:717-724.
19. Kuramochi T, Kakefuda A, Yamada H, Tsukamoto I, Taguchi T, and Sakamoto S (2005b) Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor. Bioorg Med Chem 13:4022-4036.
20. 2+ exchange inhibitors in attenuating ischemia-reperfusion injury. Can J Cardiol 21:509-516.
21. 2+ exchanger. J Biol Chem 266:1014-1020.
22. 2+ increase and neuronal injury induced by polychlorinated biphenyls in human neuroblastoma SH-SY5Y cells. J Pharmacol Exp Ther 315:291-296.
23. 2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther 298:249-256.
24. 2+ exchanger by the endogenous XIP region. J Gen Physiol 109:273-286.
25. 2+-binding domain. J Gen Physiol 105:403-420.
26. 2+ exchange inhibitor, on myocardial ischemia/reperfusion injury. Folia Pharmacol Jpn 111:105-115.
27. 2+ exchanger. J Biol Chem 271:13385-13391.
28. 2+ exchanger. J Biol Chem 274:910-917.
29. 2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury. Eur J Pharmacol 478:187-198.
30. Philipson KD and Nicoll DA (2000) Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol 62:111-133.
31. Pignataro G, Gala R, Cuomo O, Tortiglione A, Giaccio L, Castaldo P, Sirabella R, Matrone C, Canitano A, and Amoroso S, et al. (2004) Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35:2566-2570.
32. 2+ exchange inhibitor KB-R7943 also blocks native and expressed neuronal nicotinic receptors. Br J Pharmacol 130:1893-1902.
33. 2+ exchanger isoforms NCX1, NCX2 and NCX3 in rat. Am J Physiol 272:C1250-C1261.
34. 2+ exchange inhibitors. Circ Res 91:90-92.
35. 2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury. Neuropharmacology 38:319-321.
36. 2+ exchange: molecular and pharmacological aspects. Circ Res 88:864-876.
37. 2+ exchanger, on myocardial ischemia-reperfusion injuries. Eur J Pharmacol 458:155-162.
38. Tanaka H, Nishimaru K, Aikawa T, Hirayama W, Tanaka Y, and Shigenobu K (2002) Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Br J Pharmacol 135:1096-1100.
39. 2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol 119:555-563.
40. 2+ exchanger. J Pharmacol Exp Ther 304:284-293.