Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded bispecific antibody comprising of two single-chain antibodies linked to the antibody constant region

Journal of Biochemistry

Volumn 140, Issue 3, 2006, Pages 359-368

  Natsume, Akito ^a   Wakitani, Masako ^a   Yamane Ohnuki, Naoko ^a   Shoji Hosaka, Emi ^a   Niwa, Rinpei ^a   Uchida, Kazuhisa ^a   Satoh, Mitsuo ^a   Shitara, Kenya ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Antibody dependent cellular cytotoxicity; Bispecific antibody; Cancer therapy; Glyco modification; Single chain Fv

Indexed keywords

1,6 FUCOSYLTRANSFERASE; BISPECIFIC ANTIBODY; FUCOSE; FUCOSYLTRANSFERASE; GLYCOPROTEIN; MUCIN 1; OLIGOSACCHARIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TAG 72 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN BINDING; ARTICLE; CHO CELL; CONTROLLED STUDY; FUCOSYLATION; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODY SPECIFICITY; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, NEOPLASM; CA-15-3 ANTIGEN; CHO CELLS; CRICETINAE; CRICETULUS; FUCOSE; GENETIC VECTORS; GLYCOPROTEINS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; OLIGOSACCHARIDES;

EID: 33750741418     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj157     Document Type: Article

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