Single-step purification of bispecific monoclonal antibodies for immunotherapeutic use by hydrophobic interaction chromatography

Journal of Immunological Methods

Volumn 208, Issue 1, 1997, Pages 65-73

  Manzke, Oliver ^a   Tesch, Hans ^a   Diehl, Volker ^a   Bohlen, Heribert ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Bioreactor; Bispecific antibodies; Clinical grade; Hydrophobic interaction chromatography; Purification

Indexed keywords

BISPECIFIC ANTIBODY; MONOCLONAL ANTIBODY;

ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG PURIFICATION; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HUMAN CELL; HYBRIDOMA; ISOELECTRIC FOCUSING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD19; ANTIGENS, CD28; ANTIGENS, CD3; BIOREACTORS; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOTOXICITY TESTS, IMMUNOLOGIC; HUMANS; HYBRIDOMAS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULINS; LYMPHOCYTE ACTIVATION; MICE; SEPHAROSE;

EID: 0031444874     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(97)00129-4     Document Type: Article

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