Local gene transfer to calcified tissue cells using prolonged infusion of a lentiviral vector

Gene Therapy

Volumn 13, Issue 22, 2006, Pages 1595-1602

  Wazen, R M ^a   Moffatt, P ^a   Zalzal, S F ^a   Daniel, N G ^b   Westerman, K A ^c   Nanci, A ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMELOBLASTIN; GREEN FLUORESCENT PROTEIN; MATRIX PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE MINERALIZATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INFUSION; FEASIBILITY STUDY; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRUS VECTOR; MANDIBLE; MOUSE; NEWBORN; NONHUMAN; NONVIRAL GENE THERAPY; OSMOTIC MINIPUMP; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; PRIORITY JOURNAL; RAT; TIBIA; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BLOTTING, WESTERN; CALCINOSIS; CELL LINE; DENTAL ENAMEL PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; LENTIVIRUS; MALE; MANDIBLE; MICROSCOPY, FLUORESCENCE; OSTEOBLASTS; OSTEOGENESIS; RATS; RATS, WISTAR; TIBIA; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 33750622752     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302824     Document Type: Article

References (58)

1. Evans CH, Ghivizzani SC, Robbins PD. The 2003 Nicolas Andry Award. Orthopaedic gene therapy. Clin Orthop Relat Res 2004; 429: 316-329.
2. Kofron MD, Laurencin CT. Orthopaedic applications of gene therapy. Curr Gene Ther 2005; 5: 37-61.
3. Jin QM, Anusaksathien O, Webb SA, Rutherford RB, Giannobile WV. Gene therapy of bone morphogenetic protein for periodontal tissue engineering. J Periodontol 2003; 74: 202-213.
4. Partridge KA, Oreffo ROC. Gene delivery in bone tissue engineering: progress and prospects using viral and nonviral strategies. Tissue Eng 2004; 10: 295-307.
5. Katsube K, Bishop AT, Simari RD, Yla-Herttuala S, Friedrich PF. Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone. J Orthop Res 2005; 23: 469-474.
6. Musgrave DS, Bosch P, Ghivizzani S, Robbins PD, Evans CH, Huard J. Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone 1999; 24: 541-547.
7. Alden TD, Beres EJ, Laurent JS, Engh JA, Das S, London SD et al. The use of bone morphogenetic protein gene therapy in craniofacial bone repair. J Craniofac Surg 2000; 11: 24-30.
8. Luk KD, Chen Y, Cheung KM, Kung HF, Lu WW, Leong JC. Adeno-associated virus-mediated bone morphogenetic protein-4 gene therapy for in vivo bone formation. Biochem Biophys Res Commun 2003; 308: 636-645.
9. Chen Y, Luk KD, Cheung KM, Xu R, Lin MC, Lu WW et al. Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors. Gene Therapy 2003; 10: 1345-1353.
10. Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD et al. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 2002; 5: 397-404.
11. Hiltunen MO, Ruuskanen M, Huuskonen J, Mahonen AJ, Ahonen M, Rutanen J et al. Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB J 2003; 17: 1147-1149.
12. Robbins PD, Evans CH, Chernajovsky Y. Gene therapy for arthritis. Gene Therapy 2003; 10: 902-911.
13. Kuboki T, Nakanishi T, Kanyama M, Sonoyama W, Fujisawa T, Kobayashi K et al. Direct adenovirus-mediated gene delivery to the temporomandibular joint in guinea-pigs. Arch Oral Biol 1999; 44: 701-709.
14. Watanabe S, Imagawa T, Boivin GP, Gao GP, Wilson JM, Hirsch R. Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mol Ther 2000; 2: 147-152.
15. Ashinoff RL, Cetrulo Jr CL, Galiano RD, Dobryansky M, Bhatt KA, Ceradini DJ et al. Bone morphogenic protein-2 gene therapy for mandibular distraction osteogenesis. Ann Plast Surg 2004; 52: 585-590.
16. Baltzer AW, Lattermann C, Whalen JD, Wooley P, Weiss K, Grimm M et al. Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Therapy 2000; 7: 734-739.
17. Baltzer AW, Lattermann C, Whalen JD, Ghivizzani S, Wooley P, Krauspe R et al. Potential role of direct adenoviral gene transfer in enhancing fracture repair. Clin Orthop Relat Res 2000; 379 (Suppl): S120-S125.
18. Helm GA, Alden TD, Beres EJ, Hudson SB, Das S, Engh JA et al. Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. J Neurosurg 2000; 92: 191-196.
19. Kostenuik PJ, Bolon B, Morony S, Daris M, Geng ZO, Carter C et al. Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice. Bone 2004; 34: 656-664.
20. Mason JM, Grande DA, Barcia M, Grant R, Pergolizzi RG, Breitbart AS. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: Potential utility in gene therapy for osteochondral repair. Gene Therapy 1998; 5: 1098-1104.
21. Gouze E, Pawliuk R, Gouze JN, Pilapil C, Fleet C, Palmer GD et al. Lentiviral-mediated gene delivery to synovium: Potent intra-articular expression with amplification by inflammation. Mol Ther 2003; 7: 460-466.
22. Lieberman JR, Daluiski A, Stevenson S, Wu L, McAllister P, Lee YP et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg (America) 1999; 81A: 905-917.
23. Krebsbach PH, Gu K, Franceschi RT, Rutherford RB. Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. Hum Gene Ther 2000; 11: 1201-1210.
24. Yla-Herttuala S, Martin JF. Cardiovascular gene therapy. Lancet 2000; 355: 213-222.
25. Kanerva A, Hemminki A. Adenoviruses for treatment of cancer. Ann Med 2005; 37: 33-43.
26. Verma IM, Weitzman MD. Gene therapy: Twenty-first century medicine. Ann Rev Biochem 2005; 74: 711-738.
27. Newman KD, Dunn PF, Owens JW, Schulick AH, Virmani R, Sukhova G et al. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest 1995; 96: 2955-2965.
28. Federico M. Lentivirus Gene Engineering Protocols. Humana Press: New Jersey, 2003.
29. Kafri T, Blomer U, Peterson DA, Gage FH, Verma IM. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 1997; 17: 314-317.
30. Shai E, Palmon A, Panet A, Marmary Y, Sherman Y, Curran MA et al. Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction. Mol Ther 2005; 12: 137-143.
31. Naldini L, Blomer U, Gage FH, Trono D, Verma IM. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 1996; 93: 11382-11388.
32. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
33. Ghazizadeh S, Katz AB, Harrington R, Taichman LB. Lentivirus- mediated gene transfer to human epidermis. J Investig Dermatol Symp Proc 2004; 9: 269-275.
34. Sugiyama O, An DS, Kung SP, Feeley BT, Gamradt S, Liu NQ et al. Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo. Mol Ther 2005; 11: 390-398.
35. Kyrkanides S, Kambylafkas P, Miller JH, Tallents RH. Nonprimate lentiviral vector administration in the TMJ. J Dent Res 2004; 83: 65-70.
36. Franceschi RT. Biological approaches to bone regeneration by gene therapy. J Dent Res 2005; 84: 1093-1103.
37. Vu D-D, Daniel NG, Nanci A. In vivo model for the experimental manipulation of calcified tissues: A surgical approach for accessing the odontogenic organ and associated tissues in the rat incisor. J Histochem Cytochem 1999; 47: 1-14.
38. Orsini G, Zalzal S, Nanci A. Localized infusion of tunicamycin in rat hemimandibles: Alteration of the basal lamina associated with maturation stage ameloblasts. J Histochem Cytochem 2001; 49: 165-176.
39. Nanci A, Wazen RM, Zalzal S, Fortin M, Goldberg HA, Hunter GK et al. A tracer study with systemically and locally administered dinitrophenylated osteopontin. J Histochem Cytochem 2004; 52: 1591-1600.
40. Fincham AG, Moradian-Oldak J, Simmer JP. The structural biology of the developing dental enamel matrix. J Struct Biol 1999; 126: 270-299.
41. Luo J, Sun MH, Kang Q, Peng Y, Jiang W, Luu HH et al. Gene therapy for bone regeneration. Curr Gene Ther 2005; 5: 167-179.
42. Schwarz EM. The adeno-associated virus vector for orthopaedic gene therapy. Clin Orthop Relat Res 2000; 379 (Suppl): S31-S39.
43. Dai J, Rabie AB, Hagg U, Xu R. Alternative gene therapy strategies for the repair of craniofacial bone defects. Curr Gene Ther 2004; 4: 469-485.
44. Ulrich-Vinther M, Carmody EE, Goater JJ, Soballe K, O'Keefe RJ, Schwarz EM. Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. J Bone Joint Surg (America) 2002; 84A: 1405-1412.
45. Kootstra NA, Verma IM. Gene therapy with viral vectors. Annu Rev Pharmacol Toxicol 2003; 43: 413-439.
46. H-thymidine. Anat Rec 1975; 183: 523-562.
47. Li M, Amizuka N, Oda K, Tokunaga K, Ito T, Takeuchi K et al. Histochemical evidence of the initial chondrogenesis and osteogenesis in the periosteum of a rib fractured model: Implications of osteocyte involvement in periosteal chondrogenesis. Microsc Res Tech 2004; 64: 330-342.
48. Rundle CH, Miyakoshi N, Kasukawa Y, Chen ST, Sheng MH, Wergedal JE et al. In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4. Bone 2003; 32: 591-601.
49. Zhang XY, La Russa VF, Bao L, Kolls J, Schwarzenberger P, Reiser J. Lentiviral vectors for sustained transgene expression in human bone marrow-derived stromal cells. Mol Ther 2002; 5: 555-565.
50. Smith CE, Nanci A. A method for sampling the stages of amelogenesis on mandibular rat incisors using the molars as a reference for dissection. Anat Rec 1989; 225: 257-266.
51. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
52. Krebsbach PH, Lee SK, Matsuki Y, Kozak CA, Yamada KM. Fulllength sequence, localization, and chromosomal mapping of ameloblastin: A novel tooth-specific gene. J Biol Chem 1996; 271: 4431-4435.
53. Chen W-Y, Nanci A, Smith CE. Immunoblotting studies on artifactual contamination of enamel homogenates by albumin and other proteins. Calcif Tissue Int 1995; 57: 145-151.
54. Wang D, Christensen K, Chawla K, Xiao G, Krebsbach PH, Franceschi RT. Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res 1999; 14: 893-903.
55. Nanci A, Zalzal S, Gotoh Y, McKee MD. Ultrastructural characterization and immunolocalization of osteopontin in rat calvarial osteoblast primary cultures. Microsc Res Technol 1996; 33: 214-231.
56. Irie K, Zalzal S, Ozawa H, McKee MD, Nanci A. Morphological and immunocytochemical characterization of primary osteogenic cell cultures derived from fetal rat cranial tissue. Anat Rec 1998; 252: 554-567.
57. Tambasco De Oliveira P, Zalzal S, Irie K, Nanci A. Early expression of bone matrix proteins in osteogenic cell cultures. J Histochem Cytochem 2003; 51: 633-641.
58. Warshawsky H, Moore G. A technique for the fixation and decalcification of rat incisors for electron microscopy. J Histochem Cytochem 1967; 15: 542-549.