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Volumn 65, Issue 11, 2006, Pages 1059-1068

The human prion protein residue 129 polymorphism lies within a cluster of epitopes for T cell recognition

Author keywords

Creutzfeldt Jakob disease; Prion protein; T cell responses

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 6; PRION PROTEIN;

EID: 33750599513     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000240467.18381.49     Document Type: Article
Times cited : (4)

References (60)
  • 1
    • 0034916581 scopus 로고    scopus 로고
    • Prion diseases of humans and animals: Their causes and molecular basis
    • Collinge J. Prion diseases of humans and animals: Their causes and molecular basis. Annu Rev Neurosci 2001;24:519-50
    • (2001) Annu Rev Neurosci , vol.24 , pp. 519-550
    • Collinge, J.1
  • 2
    • 0014190760 scopus 로고
    • Self-replication and scrapie
    • Griffith JS. Self-replication and scrapie. Nature 1967;215:1043-44
    • (1967) Nature , vol.215 , pp. 1043-1044
    • Griffith, J.S.1
  • 3
    • 0020321767 scopus 로고
    • Novel proteinaceous infectious particles cause scrapie
    • Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982;216:136-44
    • (1982) Science , vol.216 , pp. 136-144
    • Prusiner, S.B.1
  • 4
    • 0036917840 scopus 로고    scopus 로고
    • The immune system and prion diseases: A relationship of complicity and blindness
    • Aucouturier P, Carnaud C. The immune system and prion diseases: A relationship of complicity and blindness. J Leukoc Biol 2002;72:1075-83
    • (2002) J Leukoc Biol , vol.72 , pp. 1075-1083
    • Aucouturier, P.1    Carnaud, C.2
  • 5
    • 0023663071 scopus 로고
    • Scrapie prion protein contains a phosphatidylinositol glycolipid
    • Stahl N, Borchelt DR, Hsiao K, et al. Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 1987;51:229-40
    • (1987) Cell , vol.51 , pp. 229-240
    • Stahl, N.1    Borchelt, D.R.2    Hsiao, K.3
  • 6
    • 0141515196 scopus 로고    scopus 로고
    • Putative functions of PrP(C)
    • Lasmezas CI. Putative functions of PrP(C). Br Med Bull 2003;66:61-70
    • (2003) Br Med Bull , vol.66 , pp. 61-70
    • Lasmezas, C.I.1
  • 7
    • 0027534612 scopus 로고
    • Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
    • Stahl N, Baldwin MA, Teplow DB, et al. Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry 1993;32:1991-2002
    • (1993) Biochemistry , vol.32 , pp. 1991-2002
    • Stahl, N.1    Baldwin, M.A.2    Teplow, D.B.3
  • 8
    • 0035891159 scopus 로고    scopus 로고
    • HLA-DQ7 antigen and resistance to variant CJD
    • Jackson GS, Beck JA, Navarrete C, et al. HLA-DQ7 antigen and resistance to variant CJD. Nature 2001;414:269-70
    • (2001) Nature , vol.414 , pp. 269-270
    • Jackson, G.S.1    Beck, J.A.2    Navarrete, C.3
  • 9
    • 0037425776 scopus 로고    scopus 로고
    • MHC typing in variant Creutzfeldt-Jakob disease
    • Pepys MB, Bybee A, Booth DR, et al. MHC typing in variant Creutzfeldt-Jakob disease. Lancet 2003;361:487-89
    • (2003) Lancet , vol.361 , pp. 487-489
    • Pepys, M.B.1    Bybee, A.2    Booth, D.R.3
  • 10
    • 0034730170 scopus 로고    scopus 로고
    • Species barrier independent prion replication in apparently resistant species
    • Hill AF, Joiner S, Linehan J, et al. Species barrier independent prion replication in apparently resistant species. Proc Natl Acad Sci U S A 2000;97:10248-53
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 10248-10253
    • Hill, A.F.1    Joiner, S.2    Linehan, J.3
  • 11
    • 1142273431 scopus 로고    scopus 로고
    • Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion
    • Llewelyn CA, Hewitt PE, Knight RS, et al. Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 2004;363:417-21
    • (2004) Lancet , vol.363 , pp. 417-421
    • Llewelyn, C.A.1    Hewitt, P.E.2    Knight, R.S.3
  • 12
    • 4043157677 scopus 로고    scopus 로고
    • Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient
    • Peden AH, Head MW, Ritchie DL, et al. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 2004;364:527-29
    • (2004) Lancet , vol.364 , pp. 527-529
    • Peden, A.H.1    Head, M.W.2    Ritchie, D.L.3
  • 13
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-77
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 14
    • 0038100154 scopus 로고    scopus 로고
    • Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    • Hock C, Konietzko U, Streffer JR, et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003;38:547-54
    • (2003) Neuron , vol.38 , pp. 547-554
    • Hock, C.1    Konietzko, U.2    Streffer, J.R.3
  • 15
    • 0141782730 scopus 로고    scopus 로고
    • Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent
    • Schwarz A, Kratke O, Burwinkel M, et al. Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent. Neurosci Lett 2003;350:187-89
    • (2003) Neurosci Lett , vol.350 , pp. 187-189
    • Schwarz, A.1    Kratke, O.2    Burwinkel, M.3
  • 16
    • 21144432949 scopus 로고    scopus 로고
    • Mucosal vaccination delays or prevents prion infection via an oral route
    • Goni F, Knudsen E, Schreiber F, et al. Mucosal vaccination delays or prevents prion infection via an oral route. Neuroscience 2005;133:413-21
    • (2005) Neuroscience , vol.133 , pp. 413-421
    • Goni, F.1    Knudsen, E.2    Schreiber, F.3
  • 17
    • 20144377217 scopus 로고    scopus 로고
    • Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters
    • Magri G, Clerici M, Dall'Ara P, et al. Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters. Vaccine 2005;23:2862-68
    • (2005) Vaccine , vol.23 , pp. 2862-2868
    • Magri, G.1    Clerici, M.2    Dall'Ara, P.3
  • 18
    • 0036317750 scopus 로고    scopus 로고
    • Immunization delays the onset of prion disease in mice
    • Sigurdsson EM, Brown DR, Daniels M, et al. Immunization delays the onset of prion disease in mice. Am J Pathol 2002;161:13-17
    • (2002) Am J Pathol , vol.161 , pp. 13-17
    • Sigurdsson, E.M.1    Brown, D.R.2    Daniels, M.3
  • 19
    • 32344443856 scopus 로고    scopus 로고
    • Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy
    • Bade S, Baier M, Boetel T, et al. Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy. Vaccine 2006;24:1242-53
    • (2006) Vaccine , vol.24 , pp. 1242-1253
    • Bade, S.1    Baier, M.2    Boetel, T.3
  • 20
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after A beta 42 immunization
    • Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after A beta 42 immunization. Neurology 2003;61:46-54
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3
  • 21
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll JAR, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report. Nat Med 2003;9:448-52
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.R.1    Wilkinson, D.2    Holmes, C.3
  • 23
    • 0041825579 scopus 로고    scopus 로고
    • Cell mediated immune responses against human prion protein
    • Bainbridge J, Walker B. Cell mediated immune responses against human prion protein. Clin Exp Immunol 2003;133:310-17
    • (2003) Clin Exp Immunol , vol.133 , pp. 310-317
    • Bainbridge, J.1    Walker, B.2
  • 24
    • 3042699482 scopus 로고    scopus 로고
    • Identification of two immunogenic domains of the prion protein - PrP - Which activate class II-restricted T cells and elicit antibody responses against the native molecule
    • Gregoire S, Logre C, Metharom P, et al. Identification of two immunogenic domains of the prion protein - PrP - which activate class II-restricted T cells and elicit antibody responses against the native molecule. J Leukoc Biol 2004;76:125-34
    • (2004) J Leukoc Biol , vol.76 , pp. 125-134
    • Gregoire, S.1    Logre, C.2    Metharom, P.3
  • 25
    • 14844339706 scopus 로고    scopus 로고
    • Protein conformation significantly influences immune responses to prion protein
    • Khalili-Shirazi A, Quaratino S, Londei M, et al. Protein conformation significantly influences immune responses to prion protein. J Immunol 2005;174:3256-63
    • (2005) J Immunol , vol.174 , pp. 3256-3263
    • Khalili-Shirazi, A.1    Quaratino, S.2    Londei, M.3
  • 26
    • 0345373985 scopus 로고    scopus 로고
    • CD4+ T cell-mediated immunity against prion proteins
    • Stoltze L, Rezaei H, Jung G, et al. CD4+ T cell-mediated immunity against prion proteins. Cell Mol Life Sci 2003;60:629-38
    • (2003) Cell Mol Life Sci , vol.60 , pp. 629-638
    • Stoltze, L.1    Rezaei, H.2    Jung, G.3
  • 27
    • 2142706520 scopus 로고    scopus 로고
    • Breaking immune tolerance to the prion protein using prion protein peptides plus oligodeoxynucleotide-CpG in mice
    • Rosset MB, Ballerini C, Gregoire S, et al. Breaking immune tolerance to the prion protein using prion protein peptides plus oligodeoxynucleotide-CpG in mice. J Immunol 2004;172:5168-74
    • (2004) J Immunol , vol.172 , pp. 5168-5174
    • Rosset, M.B.1    Ballerini, C.2    Gregoire, S.3
  • 28
    • 0034856996 scopus 로고    scopus 로고
    • Modulation of proteinase-K resistant prion protein by prion peptide immunization
    • Souan L, Tal Y, Felling Y, et al. Modulation of proteinase-K resistant prion protein by prion peptide immunization. Eur J Immunol 2001;31:2338-46
    • (2001) Eur J Immunol , vol.31 , pp. 2338-2346
    • Souan, L.1    Tal, Y.2    Felling, Y.3
  • 29
    • 0037367652 scopus 로고    scopus 로고
    • The use of bioinformatics for identifying class II-restricted T-cell epitopes
    • Bian HJ, Reidhaar-Olson JF, Hammer J. The use of bioinformatics for identifying class II-restricted T-cell epitopes. Methods 2003;29:299-309
    • (2003) Methods , vol.29 , pp. 299-309
    • Bian, H.J.1    Reidhaar-Olson, J.F.2    Hammer, J.3
  • 30
    • 7944224384 scopus 로고    scopus 로고
    • Discovery of promiscuous HLA-II-restricted T cell epitopes with TEPITOPE
    • Bian HJ, Hammer J. Discovery of promiscuous HLA-II-restricted T cell epitopes with TEPITOPE. Methods 2004;34:468-75
    • (2004) Methods , vol.34 , pp. 468-475
    • Bian, H.J.1    Hammer, J.2
  • 31
    • 0029618012 scopus 로고
    • Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
    • Bunce M, O'Neill CM, Barnardo MC, et al. Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995;46:355-67
    • (1995) Tissue Antigens , vol.46 , pp. 355-367
    • Bunce, M.1    O'Neill, C.M.2    Barnardo, M.C.3
  • 32
    • 0032956989 scopus 로고    scopus 로고
    • A DNA-based detection and screening system for identifying HLA class I expression variants by sequence-specific primers
    • Bunce M, Procter J, Welsh KI. A DNA-based detection and screening system for identifying HLA class I expression variants by sequence-specific primers. Tissue Antigens 1999;53:498-506
    • (1999) Tissue Antigens , vol.53 , pp. 498-506
    • Bunce, M.1    Procter, J.2    Welsh, K.I.3
  • 33
    • 0035928432 scopus 로고    scopus 로고
    • Tissue distribution of protease resistant prion protein in variant CJD using a highly sensitive immuno-blotting assay
    • Wadsworth JDF, Joiner S, Hill AF, et al. Tissue distribution of protease resistant prion protein in variant CJD using a highly sensitive immuno-blotting assay. Lancet 2001;358:171-80
    • (2001) Lancet , vol.358 , pp. 171-180
    • Wadsworth, J.D.F.1    Joiner, S.2    Hill, A.F.3
  • 34
    • 25444525438 scopus 로고    scopus 로고
    • High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease
    • Joiner S, Linehan JM, Brandner S, et al. High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease. Gut 2005;54:1506-08
    • (2005) Gut , vol.54 , pp. 1506-1508
    • Joiner, S.1    Linehan, J.M.2    Brandner, S.3
  • 35
    • 0242361687 scopus 로고    scopus 로고
    • Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease
    • Glatzel M, Abela E, Maissen M, et al. Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. N Engl J Med 2003;349:1812-20
    • (2003) N Engl J Med , vol.349 , pp. 1812-1820
    • Glatzel, M.1    Abela, E.2    Maissen, M.3
  • 36
    • 16244394033 scopus 로고    scopus 로고
    • Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease
    • Cunningham C, Wilcockson DC, Boche D, et al. Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease. J Virol 2005;79:5174-84
    • (2005) J Virol , vol.79 , pp. 5174-5184
    • Cunningham, C.1    Wilcockson, D.C.2    Boche, D.3
  • 37
    • 0037333853 scopus 로고    scopus 로고
    • T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies
    • Lewicki H, Tishon A, Homann D, et al. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies. J Virol 2003;77:3799-808
    • (2003) J Virol , vol.77 , pp. 3799-3808
    • Lewicki, H.1    Tishon, A.2    Homann, D.3
  • 38
    • 0036267207 scopus 로고    scopus 로고
    • Atypical inflammation in the central nervous system in prion disease
    • Perry VH, Cunningham C, Boche D. Atypical inflammation in the central nervous system in prion disease. Curr Opin Neurol 2002;15:349-54
    • (2002) Curr Opin Neurol , vol.15 , pp. 349-354
    • Perry, V.H.1    Cunningham, C.2    Boche, D.3
  • 39
    • 18244409880 scopus 로고    scopus 로고
    • Spread of T lymphocyte immune responses to myelin epitopes with duration of multiple sclerosis
    • Davies S, Nicholson T, Laura M, et al. Spread of T lymphocyte immune responses to myelin epitopes with duration of multiple sclerosis. J Neuropathol Exp Neurol 2005;64:371-77
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 371-377
    • Davies, S.1    Nicholson, T.2    Laura, M.3
  • 40
    • 0029830124 scopus 로고    scopus 로고
    • APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease
    • Trieb K, Ransmayr G, Sgonc R, et al. APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease. Neurobiol Aging 1996;17:541-47
    • (1996) Neurobiol Aging , vol.17 , pp. 541-547
    • Trieb, K.1    Ransmayr, G.2    Sgonc, R.3
  • 41
    • 0037262642 scopus 로고    scopus 로고
    • T cell response to amyloid-beta and to mitochondrial antigens in Alzheimer's disease
    • Giubilei F, Antonini G, Montesperelli C, et al. T cell response to amyloid-beta and to mitochondrial antigens in Alzheimer's disease. Dement Geriatr Cogn Disord 2003;16:35-38
    • (2003) Dement Geriatr Cogn Disord , vol.16 , pp. 35-38
    • Giubilei, F.1    Antonini, G.2    Montesperelli, C.3
  • 42
    • 0041886776 scopus 로고    scopus 로고
    • Increased T cell reactivity to amyloid b protein in older humans and patients with Alzheimer disease
    • Monsonego A, Zota V, Karni A, et al. Increased T cell reactivity to amyloid b protein in older humans and patients with Alzheimer disease. J Clin Invest 2003;112:415-22
    • (2003) J Clin Invest , vol.112 , pp. 415-422
    • Monsonego, A.1    Zota, V.2    Karni, A.3
  • 43
    • 1542347153 scopus 로고    scopus 로고
    • Immune response to A beta-peptides in peripheral blood from patients with Alzheimer's disease and control subjects
    • Baril L, Nicolas L, Croisile B, et al. Immune response to A beta-peptides in peripheral blood from patients with Alzheimer's disease and control subjects. Neurosci Lett 2004;355:226-30
    • (2004) Neurosci Lett , vol.355 , pp. 226-230
    • Baril, L.1    Nicolas, L.2    Croisile, B.3
  • 44
    • 0025212147 scopus 로고
    • Cellular isoform of the scrapie agent protein participates in lymphocyte activation
    • Cashman NR, Loertscher R, Nalbantoglu J, et al. Cellular isoform of the scrapie agent protein participates in lymphocyte activation. Cell 1990;61:185-92
    • (1990) Cell , vol.61 , pp. 185-192
    • Cashman, N.R.1    Loertscher, R.2    Nalbantoglu, J.3
  • 45
    • 1342329324 scopus 로고    scopus 로고
    • Prion protein is a component of the multimolecular signaling complex involved in T cell activation
    • Mattei V, Garofalo T, Misasi R, et al. Prion protein is a component of the multimolecular signaling complex involved in T cell activation. FEBS Lett 2004;560:14-18
    • (2004) FEBS Lett , vol.560 , pp. 14-18
    • Mattei, V.1    Garofalo, T.2    Misasi, R.3
  • 46
    • 4444325310 scopus 로고    scopus 로고
    • Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection
    • Polymenidou M, Heppner FL, Pellicioli EC, et al. Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection. Proc Natl Acad Sci U S A 2004;101:14670-76
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14670-14676
    • Polymenidou, M.1    Heppner, F.L.2    Pellicioli, E.C.3
  • 47
    • 0033847725 scopus 로고    scopus 로고
    • Different levels of prion protein (PrPc) expression on hamster, mouse and human blood cells
    • Holada K, Vostal JG. Different levels of prion protein (PrPc) expression on hamster, mouse and human blood cells. Br J Haematol 2000;110:472-80
    • (2000) Br J Haematol , vol.110 , pp. 472-480
    • Holada, K.1    Vostal, J.G.2
  • 48
    • 4444298682 scopus 로고    scopus 로고
    • Recent developments in prion immunotherapy
    • Heppner FL, Aguzzi A. Recent developments in prion immunotherapy. Curr Opin Immunol 2004;16:594-98
    • (2004) Curr Opin Immunol , vol.16 , pp. 594-598
    • Heppner, F.L.1    Aguzzi, A.2
  • 49
    • 27744463376 scopus 로고    scopus 로고
    • The murine B cell repertoire is severely selected against endogenous cellular prion protein
    • Gregoire S, Bergot AS, Feraudet C, et al. The murine B cell repertoire is severely selected against endogenous cellular prion protein. J Immunol 2005;175:6443-49
    • (2005) J Immunol , vol.175 , pp. 6443-6449
    • Gregoire, S.1    Bergot, A.S.2    Feraudet, C.3
  • 50
    • 0035698098 scopus 로고    scopus 로고
    • Self prion protein peptides are immunogenic in Lewis rats
    • Souan L, Margalit R, Brenner O, et al. Self prion protein peptides are immunogenic in Lewis rats. J Autoimmun 2001;17:303-10
    • (2001) J Autoimmun , vol.17 , pp. 303-310
    • Souan, L.1    Margalit, R.2    Brenner, O.3
  • 51
    • 1642495749 scopus 로고    scopus 로고
    • Quantitative analysis of prion-protein degradation by constitutive and immuno-20s proteasomes indicates differences correlated with disease susceptibility
    • Tenzer S, Stoltze L, Schonfisch B, et al. Quantitative analysis of prion-protein degradation by constitutive and immuno-20s proteasomes indicates differences correlated with disease susceptibility. J Immunol 2004;172:1083-91
    • (2004) J Immunol , vol.172 , pp. 1083-1091
    • Tenzer, S.1    Stoltze, L.2    Schonfisch, B.3
  • 52
    • 84925549112 scopus 로고    scopus 로고
    • The paradigm of IL-6: From basic science to medicine
    • Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: From basic science to medicine. Arthritis Res 2002;4 (suppl 3): S233-42
    • (2002) Arthritis Res , vol.4 , Issue.SUPPL. 3
    • Naka, T.1    Nishimoto, N.2    Kishimoto, T.3
  • 53
    • 0042570765 scopus 로고    scopus 로고
    • Activation by prion peptide PrP (106-126) induces a NF-kappaB-driven proinflammatory response in human monocyte-derived dendritic cells
    • Bacot SM, Lenz P, Frazier-Jessen MR, et al. Activation by prion peptide PrP (106-126) induces a NF-kappaB-driven proinflammatory response in human monocyte-derived dendritic cells. J Leukoc Biol 2003;74:118-25
    • (2003) J Leukoc Biol , vol.74 , pp. 118-125
    • Bacot, S.M.1    Lenz, P.2    Frazier-Jessen, M.R.3
  • 54
    • 0035689506 scopus 로고    scopus 로고
    • C-reactive protein and IL-6: New marker proteins for the diagnosis of CJD in plasma?
    • Volkel D, Zimmermann K, Zerr I, et al. C-reactive protein and IL-6: New marker proteins for the diagnosis of CJD in plasma? Transfusion 2001;41:1509-14
    • (2001) Transfusion , vol.41 , pp. 1509-1514
    • Volkel, D.1    Zimmermann, K.2    Zerr, I.3
  • 55
    • 0031058726 scopus 로고    scopus 로고
    • Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4(+) T cells
    • Rincon M, Anguita J, Nakamura T, et al. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4(+) T cells. J Exp Med 1997;185:461-69
    • (1997) J Exp Med , vol.185 , pp. 461-469
    • Rincon, M.1    Anguita, J.2    Nakamura, T.3
  • 56
    • 0036645028 scopus 로고    scopus 로고
    • Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation
    • Diehl S, Chow CW, Weiss L, et al. Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med 2002;196:39-49
    • (2002) J Exp Med , vol.196 , pp. 39-49
    • Diehl, S.1    Chow, C.W.2    Weiss, L.3
  • 57
    • 12244259034 scopus 로고    scopus 로고
    • Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice
    • Tal Y, Souan L, Cohen IR, et al. Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice. J Neurosci Res 2003;71:286-90
    • (2003) J Neurosci Res , vol.71 , pp. 286-290
    • Tal, Y.1    Souan, L.2    Cohen, I.R.3
  • 58
    • 0037422133 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit prion replication and delay the development of prion disease
    • White AR, Enever P, Tayebi M, et al. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 2003;422:80-83
    • (2003) Nature , vol.422 , pp. 80-83
    • White, A.R.1    Enever, P.2    Tayebi, M.3
  • 59
    • 0037384333 scopus 로고    scopus 로고
    • Adjuvant-dependent modulation of T(h)1 and T(h)2 responses to immunization with beta-amyloid
    • Cribbs DH, Ghochikyan A, Vasilevko V, et al. Adjuvant-dependent modulation of T(h)1 and T(h)2 responses to immunization with beta-amyloid. Int Immunol 2003;15:505-14
    • (2003) Int Immunol , vol.15 , pp. 505-514
    • Cribbs, D.H.1    Ghochikyan, A.2    Vasilevko, V.3
  • 60
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning. Nat Rev Neurosci 2002;3:824-28
    • (2002) Nat Rev Neurosci , vol.3 , pp. 824-828
    • Schenk, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.