Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L Activity (Calcified Tissue International (2006) 79 (245-254) DOI: 10.1007/s00223-005-0289-z);Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity

Calcified Tissue International

Volumn 79, Issue 4, 2006, Pages 245-254

  Perez Amodio, S ^a   Jansen, D C ^a   Schoenmaker, T ^a   Vogels, I M C ^b   Reinheckel, T ^c   Hayman, A R ^d   Cox, T M ^e   Saftig, P ^f   Beertsen, W ^a   Everts, V ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF KIEL   (Germany)

Author keywords

Cysteine proteinase; Osteoclast; Tartrate resistant acid phosphatase

Indexed keywords

ACID PHOSPHATASE; CATHEPSIN K; CATHEPSIN L; TARTARIC ACID;

AMINO ACID SEQUENCE; ARTICLE; BONE CELL; CELL ISOLATION; CONTROLLED STUDY; GENOTYPE; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL;

EID: 33750561888     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-006-1024-0     Document Type: Erratum

References (58)

1. Vaananen HK, Horton M (1995) The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. J Cell Sci 108:2729-2732
2. Mulari M, Vaaraniemi J, Vaananen HK (2003) Intracellular membrane trafficking in bone resorbing osteoclasts. Microsc Res Tech 61:496-503
3. Debari K, Sasaki T, Udagawa N, Rifkin BR (1995) An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions. Calcif Tissue Int 56:566-570
4. Everts V, Beertsen W, Schroeder R (1988) Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption. Calcif Tissue Int 43:172-178
5. Xia L, Kilb J, Wex H, Li Z, Lipyansky A, Breuil V, Stein L, Palmer JT, Dempster DW, Bromme D (1999) Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Biol Chem 380:679-687
6. Salo J, Lehenkari P, Mulari M, Metsikko K, Vaananen HK (1997) Removal of osteoclast bone resorption products by transcytosis. Science 276:270-273
7. Nesbitt SA, Norton MA (1997) Trafficking of matrix collagens through bone-resorbing osteoclasts. Science 276:266-269
8. Zaidi M, Moonga B, Moss DW, MacIntyre I (1989) Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochem Biophys Res Commun 159:68-71
9. Moonga BS, Moss DW, Patchell A, Zaidi M (1990) Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption. J Physiol 429:29-45
10. Hayman AR, Jones SJ, Boyde A, Foster D, Colledge WH, Carlton MB, Evans MJ, Cox TM (1996) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development 122:3151-3162
11. Suter A, Everts V, Boyde A, Jones SJ, Lullmann-Rauch R, Hartmann D, Hayman AR, Cox TM, Evans MJ, Meister T, von Figura K, Saftig P (2001) Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. Development 128:4899-4910
12. Angel NZ, Walsh N, Forwood MR, Ostrowski MC, Cassady AI, Hume DA (2000) Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover. J Bone Miner Res 15:103-110
13. Andersson G, Ek-Rylander B (1995) The tartrate-resistant purple acid phosphatase of bone osteoclasts - a protein phosphatase with multivalent substrate specificity and regulation. Acta Orthop Scand Suppl 266:189-194
14. Ek-Rylander B, Flores M, Wendel M, Heinegard D, Andersson G (1994) Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro. J Biol Chem 269:14853-14856
15. Hollberg K, Hultenby K, Hayman A, Cox T, Andersson G (2002) Osteoclasts from mice deficient in tartrate-resistant acid phosphatase have altered ruffled borders and disturbed intracellular vesicular transport. Exp Cell Res 279:227-238
16. Ljusberg J, Ek-Rylander B, Andersson G (1999) Tartrate-resistant purple acid phosphatase is synthesized as a latent proenzyme and activated by cysteine proteinases. Biochem J 343:63-69
17. Funhoff EG, Ljusberg J, Wang Y, Andersson G, Averill BA (2001) Mutational analysis of the interaction between active site residues and the loop region in mammalian purple acid phosphatases. Biochemistry 40:11614-11622
18. Ljusberg J, Wang Y, Lang P, Norgard M, Dodds R, Hultenby K, Ek-Rylander B, Andersson G (2005) Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem 280:28370-28381
19. Ljusberg J, Dodds RA, Lark MW, Gowen M, Lazner F, Kola I, Ek-Rylander B, Andersson G (1999) Tartrate-resistant/purple acid phosphatase is proteolytically cleaved in vivo by cathepsin K. J Bone Miner Res 14(suppl):358
20. Dodds RA, Connor JR, Drake F, Feild J, Gowen M (1998) Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development. J Bone Miner Res 13:673-682
21. Drake FH, Dodds RA, James IE, Connor JR, Debouck C, Richardson S, Lee-Rykaczewski E, Coleman L, Rieman D, Barthlow R, Hastings G, Gowen M (1996) Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem 271:12511-12516
22. Littlewood-Evans A, Kokubo T, Ishibashi O, Inaoka T, Wlodarski B, Gallagher JA, Bilbe G (1997) Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Bone 20:81-86
23. Yamaza T, Goto T, Kamiya T, Kobayashi Y, Sakai H, Tanaka T (1998) Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur. Bone 23:499-509
24. Katunuma N, Matsui A, Inubushi T, Murata E, Kakegawa H, Ohba Y, Turk D, Turk V, Tada Y, Asao T (2000) Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo. Biochem Biophys Res Commun 267:850-854
25. Thompson SK, Halbert SM, Bossard MJ, Tomaszek TA, Levy MA, Zhao B, Smith WW, Abdel-Meguid SS, Janson CA, D'Alessio KJ, McQueney MS, Amegadzie BY, Hanning CR, DesJarlais RL, Briand J, Sarkar SK, Huddleston MJ, Ijames CF, Carr SA, Garnes KT, Shu A, Heys JR, Bradbeer J, Zembryki D, Veber DF (1997) Design of potent and selective human cathepsin K inhibitors that span the active site. Proc Natl Acad Sci USA 94:14249-14254
26. Votta BJ, Levy MA, Badger A, Bradbeer J, Dodds RA, James IE, Thompson S, Bossard MJ, Carr T, Connor JR, Tomaszek TA, Szewczuk L, Drake FH, Veber DF, Gowen M (1997) Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo. J Bone Miner Res 12:1396-1406
27. Inui T, Ishibashi O, Inaoka T, Origane Y, Kumegawa M, Kokubo T, Yamamura T (1997) Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption. J Biol Chem 272:8109-8112
28. Gowen M, Lazner F, Dodds R, Kapadia R, Feild J, Tavaria M, Bertoncello I, Drake F, Zavarselk S, Tellis I, Hertzog P, Debouck C, Kola I (1999) Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J Bone Miner Res 14:1654-1663
29. Saftig P, Hunziker E, Wehmeyer O, Jones S, Boyde A, Rommerskirch W, Moritz JD, Schu P, von Figura K (1998) Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci USA 95:13453-13458
30. Goto T, Tsukuba T, Kiyoshima T, Nishimura Y, Kato K, Yamamoto K, Tanaka T (1993) Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast. Histochemistry 99:411-414
31. Goto T, Kiyoshima T, Moroi R, Tsukuba T, Nishimura Y, Himeno M, Yamamoto K, Tanaka T (1994) Localization of cathepsins B, D, and L in the rat osteoclast by immuno-light and -electron microscopy. Histochemistry 101:33-40
32. Guay J, Falgueyret JP, Ducret A, Percival MD, Mancini JA (2000) Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides. Eur J Biochem 267:6311-6318
33. Ishibashi O, Inui T, Mori Y, Kurokawa T, Kokubo T, Kumegawa M (2001) Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR. Calcif Tissue Int 68:109-116
34. Everts V, Delaisse JM, Korper W, Beertsen W (1998) Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone. J Bone Miner Res 13:1420-1430
35. Hill PA, Buttle DJ, Jones SJ, Boyde A, Murata M, Reynolds JJ, Meikle MC (1994) Inhibition of bone resorption by selective inactivators of cysteine proteinases. J Cell Biochem 56:118-130
36. Rifkin BR, Vernillo AT, Kleckner AP, Auszmann JM, Rosenberg LR, Zimmerman M (1991) Cathepsin B and L activities in isolated osteoclasts. Biochem Biophys Res Commun 179:63-69
37. Everts V, Korper W, Jansen DC, Steinfort J, Lammerse I, Heera S, Docherty AJ, Beertsen W (1999) Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone. FASEB J 13:1219-1230
38. Palmer JT, Rasnick D, Klaus JL, Bromme D (1996) Vinyl sulfones as mechanism-based cysteine protease inhibitors. J Med Chem 38:3193-3196
39. Roth W, Deussing J, Botchkarev VA, Pauly-Evers M, Saftig P, Hafner A, Schmidt P, Schmahl W, Scherer J, Anton-Lamprecht I, von Figura K, Paus R, Peters C (2000) Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and perturbation of hair follicle cycling. FASEB J 14:2075-2086
40. Kerkvliet E, Jansen I, Schoenmaker T, Beertsen W, Everts V (2003) Collagen type I, III and V differently modulate synthesis and activation of matrix metalloproteinases by cultured rabbit periosteal fibroblasts. Matrix Biol 22:217-227
41. Funhoff EG, Klaassen CH, Samyn B, Van Beeumen J, Averill BA (2001) The highly exposed loop region in mammalian purple acid phosphatase controls the catalytic activity. Chem Biochem 2:355-363
42. Kiviranta R, Morko J, Alatalo SL, Nicamhlaoibh R, Risteli J, Laitala-Leinonen T, Vuorio E (2005) Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone 36:159-172
43. Kominami E, Tsukahara T, Bando Y, Katunuma N (1987) Autodegradation of lysosomal cysteine proteinases. Biochem Biophys Res Commun 144:749-756
44. Montenez JP, Delaisse JM, Tulkens PM, Kishore BK (1994) Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors. Life Sci 55:1199-1208
45. Delaisse JM, Andersen TL, Engsig MT, Henriksen K, Troen T, Blavier L (2003) Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc Res Tech 61:504-513
46. Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA (1996) Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J Biol Chem 271:12517-12524
47. Bromme D, Okamoto K, Wang BB, Biroc S (1996) Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. J Biol Chem 271:2126-2132
48. Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake FH, McQueney MS, Foged NT, Delmas PD, Delaisse JM (1998) The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem 273:32347-32352
49. Potts W, Bowyer J, Jones H, Tucker D, Freemont AJ, Millest M, Martin M, Vernon W, Neerunjun D, Slynn G, Harper F, Maciewicz R (2004) Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy. Int J Exp Pathol 85:85-96
50. Brage M, Lie A, Ransjö M, Kasprzykowski F, Kasprzykowska R, Abrahamson M, Grubb A, Lerner UH (2004) Osteoclastogenesis is decreased by cysteine proteinase inhibitors. Bone 34:412-424
51. Brage M, Abrahamson M, Lindström V, Grubb A, Lerner UH (2005) Different cysteine proteinases involved in bone resorption and osteoclast formation. Calcif Tissue Int 76:439-447
52. Wittrant Y, Couillaud S, Theoleyre S, Dunstan C, Heymann D, Redini F (2002) Osteoprotegerin differentially regulates protease expression in osteoclast cultures. Biochem Biophys Res Commun 293:38-44
53. Wittrant Y, Theoleyre S, Couillaud S, Dunstan C, Heymann D, Redini F (2003) Regulation of osteoclast protease expression by RANKL. Biochem Biophys Res Commun 310:774-778
54. Kirstein B, Chambers TJ, Fuller K (2006) Secretion of tartrate-resistant acid phosphatase by osteoclasts correlates with resorptive behavior. J Cell Biochem 98:1085-1094
55. Sodek KL, Tupy JH, Sodek J, Grynpas MD (2000) Relationships between bone protein and mineral in developing porcine long bone and calvaria. Bone 26:189-198
56. Shorey S, Heersche JN, Manolson MF (2004) The relative contribution of cysteine proteinases and matrix metalloproteinases to the resorption process in osteoclasts derived from long bone and scapula. Bone 35:909-917
57. Buttle DJ, Handley CJ, Ilic MZ, Saklatvala J, Murata M, Barrett AJ (1993) Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum 36:1709-1717
58. Everts V, Korper W, Docherty AJ, Beertsen W (1999) Matrix metalloproteinase inhibitors block osteoclastic resorption of calvarial bone but not the resorption of long bone. Ann NY Acad Sci 878:603-606