Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover

Journal of Bone and Mineral Research

Volumn 15, Issue 1, 2000, Pages 103-110

  Angel, Nicola Z ^a   Walsh, Nicole ^a   Forwood, Mark R ^a   Ostrowski, Michael C ^b   Cassady, A Ian ^a   Hume, David A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Macrophage; Osteoclast; RAW 264.7; SV40; TRAP

Indexed keywords

ACID PHOSPHATASE; TARTARIC ACID;

ANIMAL CELL; ARTICLE; BONE TURNOVER; ENHANCER REGION; ENZYME RELEASE; MOUSE; NONHUMAN; PROMOTER REGION; REGULATORY MECHANISM; TRANSGENE;

EID: 0033962845     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.1.103     Document Type: Article

References (34)

1. Clark SA, Ambrose WW, Anderson TR, Terrell RS, Toverud SU 1989 Ultrastructural localization of tartrate-resistant, purple acid phosphatase in rat osteoclasts by histochemistry and immunocytochemistry. J Bone Miner Res 4:399-405.
2. Bresciani R, von Figura K 1996 Dephosphorylation of the mannose-6-phosphate recognition marker is localized in later compartments of the endocytic route. Identification of purple acid phosphatase (uteroferrin) as the candidate phosphatase. Eur J Biochem 238:669-674.
3. Zaidi M, Moonga B, Moss DW, MacIntyre I 1989 Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochem Biophys Res Commun 159:68-71.
4. Hayman AR, Jones SJ, Boyde A, Foster D, Colledge WH, Carlton MB, Evans MJ, Cox TM 1996 Mice lacking tartrate-resistant acid phosphatase (Acp5) have disrupted endochondral ossification and mild osteopetrosis. Development 122:3151-3162.
5. Simmen RCM, Srinivas V, Roberts RM 1989 cDNA sequence, gene organization and progesterone induction of mRNA for uteroferrin, a porcine iron transport protein. DNA 8:543-554.
6. Cassady AI, King AG, Cross NC, Hume DA 1993 Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase. Gene 130:201-207.
7. Fleckenstein E, Dirks W, Dehmel U, Drexel HG 1996 Cloning and characterization of the human tartrate-resistant acid phosphatase (TRAP) gene. Leukemia 10:637-643.
8. Reddy SV, Scarcez T, Windle JJ, Leach RJ, Hundley JE, Chirgwin JM, Chou JY, Roodman GD 1993 Cloning and characterization of the 5′-flanking region of the mouse tartrate-resistant acid phosphatase gene. J Bone Miner Res 8:1263-1270.
9. Lord DK, Cross NCP, Bevilacqua MA, Rider SH, Gorman PA, Groves AV, Moss DW, Sheer D, Cox TM 1990 Type 5 acid phosphatase: Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage. Eur J Biochem 189:287-293.
10. Moonga BS, Moss DW, Patchell A, Zaidi M 1990 Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption. J Physiol 429:29-45.
11. Lacey DL, Erdmann JM, Tan H-L 1994 Interleukin 4 increases type 5 acid phosphatase mRNA expression in murine bone marrow macrophages. J Cell Biochem 54:365-371.
12. Alcantara O, Reddy S, Roodman G, Boldt D 1994 Transcriptional regulation of the tartrate-resistant acid phosphatase gene (TRAP) gene by iron. Biochem J 298:421-425.
13. Reddy SV, Alcantara O, Roodman GD, Boldt DH 1996 Inhibition of tartrate-resistant acid phosphatase gene expression by hemin and protoporphyrin IX. Identification of a hemin-responsive inhibitor of transcription. Blood 88:2288-2297.
14. Tanaka S, Amling M, Neff L, Peyman A, Uhlmann E, Levy JB, Baron R 1996 c-Cb1 is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature 383:528-531.
15. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
16. Cassady AI, Stacey KJ, Nimmo KA, Murphy KM, von der Ahe D, Pearson D, Botteri FM, Nagamine Y, Hume DA 1991 Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5′ non-coding sequences that are conserved between mouse and pig. Nucleic Acids Res 19:6839-6847.
17. Hogan B, Beddington R, Costantini F, Lacy E 1994 Manipulating the Mouse Embryo. A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, New York, NY, U.S.A.
18. Campbell HD, Dionysius DA, Keough DT, Wilson BE, de Jersey J, Zerner B 1978 Iron-containing acid phosphatases: Comparison of the enzymes from beef spleen and pig allantoic fluid. Biochem Biophys Res Commun 82:615-620.
19. Chung-Ching LJ, Sherrard J, Maloney NA, Howard GA 1987 Reactivation of inhibited bone acid phosphatase and its significance in bone histomorphometry. J Histochem Cytochem 35:1355-1363.
20. Gurr E 1962 Staining Animal Tissues: Practical and Theoretical. Leonard Hill Books Ltd., London, U.K., pp. 244-245.
21. van de Wijngaert FP, Burger EH 1986 Demonstration of tartrate-resistant acid phosphatase in un-decalcified, glycomethacrylate-embedded mouse bone: A possible marker for (pre) osteoclast identification. J Histochem Cytochem 34:1317-1323.
22. Forwood M, Owan I, Takano Y, Turner CH 1996 Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo. Am J Physiol 270:E419-E423.
23. Arnold J, Jee W 1954 Embedding and sectioning undecalcified bone and its application to radioautography. Stain Technol 29:225-239.
24. Parfitt AM 1983 The physiologic and clinical significance of bone histomorphometric data. In: Recker RR (ed) Bone Histomorphometry: Techniques and Interpretation. CRC Press, Boca Raton, FL, U.S.A., pp. 143-224.
25. Boyce BF, Wright K, Reddy SV, Koop BA, Story B, Devlin R, Leach RJ, Roodman GD, Windle JJ 1995 Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts. Endocrinol 136:5751-5759.
26. Hentunen TA, Reddy SV, Boyce BF, Devlin R, Park HR, Chung H, Selander KS, Dallas M, Kurihara N, Galson DL, Goldring SR, Koop BA, Windle JJ, Roodman GD 1998 Immortalization of osteoclast precursors by targeting Bcl-XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice. J Clin Invest 102:88-97.
27. Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE 1997 Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev 11:2835-2844.
28. Ross IL, Dunn TL, Yue X, Roy S, Barnett CJ, Hume DA 1994 Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes. Oncogene 9:121-132.
29. Reddy SV, Kuzhandaivelu N, Acosta LG, Roodman GD 1995 Characterization of the 5′-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene. Bone 16:587-593.
30. Marshall K, Nash K, Haussman G, Cassady I, Hume D, de Jersey J, Hamilton S 1997 Recombinant human and mouse purple acid phosphatases: expression and characterization. Arch Biochem Biophys 345:230-236.
31. Ek-Rylander B, Flores M, Wendel M, Heinegård D, Andersson G 1994 Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem 269:14853-14856.
32. Hayman AR, Cox TM 1994 Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein secreted by baculovirus-infected insect cells. J Biol Chem 269:1294-1300.
33. Halleen JM, Raisanen S, Salo JJ, Reddy SV, Roodman GD, Hentunen TA, Lehenkari PP, Kaija H, Vihko P, Väänänen HK 1999 Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem 274: 22907-22910.
34. Guddat LN, McAlpine AS, Hume DA, Hamilton SE, de Jersey J, Martin JL 1999 Crystal structure of mammalian purple acid phosphatase. Structure 7:757-767.