메뉴 건너뛰기




Volumn 6, Issue 6, 2006, Pages 553-558

Potential of ghrelin as a therapeutic approach for gastrointestinal motility disorders

Author keywords

[No Author keywords available]

Indexed keywords

ALEMCINAL; CAPSAICIN; GHRELIN; GHRELIN AGONIST; GHRELIN ANTAGONIST; GHRELIN RECEPTOR; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE; HORMONE RECEPTOR; IBUTAMOREN; MORPHINE; MOTILIN; MOTILIN AGONIST; MOTILIN ANTAGONIST; PEPTIDE HORMONE; PEPTIDE HORMONE ANTAGONIST; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; PROKINETIC AGENT; TZP 101; UNCLASSIFIED DRUG;

EID: 33750496964     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2006.08.005     Document Type: Review
Times cited : (37)

References (48)
  • 1
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: structure and function
    • Kojima M., and Kangawa K. Ghrelin: structure and function. Physiol Rev 85 (2005) 495-522
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 2
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25 (2004) 426-457
    • (2004) Endocr Rev , vol.25 , pp. 426-457
    • van der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 3
    • 27444446161 scopus 로고    scopus 로고
    • Ghrelin: a new player in the control of gastrointestinal functions
    • A review that discusses how the remarkable events leading to the discovery of ghrelin are related to the study of motilin, and which focuses on the effects on gastrointestinal function.
    • Peeters T.L. Ghrelin: a new player in the control of gastrointestinal functions. Gut 54 (2005) 1638-1649. A review that discusses how the remarkable events leading to the discovery of ghrelin are related to the study of motilin, and which focuses on the effects on gastrointestinal function.
    • (2005) Gut , vol.54 , pp. 1638-1649
    • Peeters, T.L.1
  • 4
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 8
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • An exciting new development, around which skepticism is presently mounting. Soon, papers challenging these findings can be expected.
    • Zhang J.V., Ren P.G., Avsian-Kretchmer O., Luo C.W., Rauch R., Klein C., and Hsueh A.J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310 (2005) 996-999. An exciting new development, around which skepticism is presently mounting. Soon, papers challenging these findings can be expected.
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3    Luo, C.W.4    Rauch, R.5    Klein, C.6    Hsueh, A.J.7
  • 9
    • 8444226059 scopus 로고    scopus 로고
    • Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus
    • Xu L., Depoortere I., Tomasetto C., Zandecki M., Tang M., Timmermans J.P., and Peeters T.L. Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regul Pept 124 (2005) 119-125
    • (2005) Regul Pept , vol.124 , pp. 119-125
    • Xu, L.1    Depoortere, I.2    Tomasetto, C.3    Zandecki, M.4    Tang, M.5    Timmermans, J.P.6    Peeters, T.L.7
  • 10
    • 15444371950 scopus 로고    scopus 로고
    • Ghrelin and energy balance: focus on current controversies
    • Detailed and balanced discussion of current controversies.
    • Cummings D.E., Foster-Schubert K.E., and Overduin J. Ghrelin and energy balance: focus on current controversies. Curr Drug Targets 6 (2005) 153-169. Detailed and balanced discussion of current controversies.
    • (2005) Curr Drug Targets , vol.6 , pp. 153-169
    • Cummings, D.E.1    Foster-Schubert, K.E.2    Overduin, J.3
  • 12
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist
    • Holst B., Cygankiewicz A., Jensen T.H., Ankersen M., and Schwartz T.W. High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Mol Endocrinol 17 (2003) 2201-2210
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 13
    • 33644658516 scopus 로고    scopus 로고
    • Ghrelin receptor mutations - too little height and too much hunger
    • A most interesting proposal about the importance of constitutive signaling, which could force us to reconsider the role of ghrelin itself.
    • Holst B., and Schwartz T.W. Ghrelin receptor mutations - too little height and too much hunger. J Clin Invest 116 (2006) 637-641. A most interesting proposal about the importance of constitutive signaling, which could force us to reconsider the role of ghrelin itself.
    • (2006) J Clin Invest , vol.116 , pp. 637-641
    • Holst, B.1    Schwartz, T.W.2
  • 14
    • 33646876842 scopus 로고    scopus 로고
    • Ghrelin acts on the dorsal vagal complex to stimulate pancreatic protein secretion
    • An elegant study describing a new effect of ghrelin: stimulation of pancreatic exocrine secretion, and the involvement of the gut-brain axis in the effect. It is only unfortunate that the authors limited the measurements to an aspecific parameter, protein secretion.
    • Li Y., Wu X., Zhao Y., Chen S., and Owyang C. Ghrelin acts on the dorsal vagal complex to stimulate pancreatic protein secretion. Am J Physiol Gastrointest Liver Physiol 290 (2006) G1350-G1358. An elegant study describing a new effect of ghrelin: stimulation of pancreatic exocrine secretion, and the involvement of the gut-brain axis in the effect. It is only unfortunate that the authors limited the measurements to an aspecific parameter, protein secretion.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Li, Y.1    Wu, X.2    Zhao, Y.3    Chen, S.4    Owyang, C.5
  • 15
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • Sun Y., Ahmed S., and Smith R.G. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23 (2003) 7973-7981
    • (2003) Mol Cell Biol , vol.23 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 18
    • 0037592273 scopus 로고    scopus 로고
    • Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    • Fujino K., Inui A., Asakawa A., Kihara N., Fujimura M., and Fujimiya M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 550 (2003) 227-240
    • (2003) J Physiol , vol.550 , pp. 227-240
    • Fujino, K.1    Inui, A.2    Asakawa, A.3    Kihara, N.4    Fujimura, M.5    Fujimiya, M.6
  • 19
    • 3142534319 scopus 로고    scopus 로고
    • Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
    • Edholm T., Levin F., Hellstrom P.M., and Schmidt P.T. Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept 121 (2004) 25-30
    • (2004) Regul Pept , vol.121 , pp. 25-30
    • Edholm, T.1    Levin, F.2    Hellstrom, P.M.3    Schmidt, P.T.4
  • 21
    • 10644280945 scopus 로고    scopus 로고
    • Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats
    • Fukuda H., Mizuta Y., Isomoto H., Takeshima F., Ohnita K., Ohba K., Omagari K., Taniyama K., and Kohno S. Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats. Scand J Gastroenterol 39 (2004) 1209-1214
    • (2004) Scand J Gastroenterol , vol.39 , pp. 1209-1214
    • Fukuda, H.1    Mizuta, Y.2    Isomoto, H.3    Takeshima, F.4    Ohnita, K.5    Ohba, K.6    Omagari, K.7    Taniyama, K.8    Kohno, S.9
  • 23
    • 33746780697 scopus 로고    scopus 로고
    • The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones
    • Bassil A.K., Dass N.B., and Sanger G.J. The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones. Eur J Pharmacol 544 (2006) 146-152
    • (2006) Eur J Pharmacol , vol.544 , pp. 146-152
    • Bassil, A.K.1    Dass, N.B.2    Sanger, G.J.3
  • 24
    • 22644444107 scopus 로고    scopus 로고
    • Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro
    • The first extensive study of the effect of ghrelin agonists on gastric emptying in mice, demonstrating a bell-shaped dose-response curve that should be kept in mind when planning applications.
    • Kitazawa T., De Smet B., Verbeke K., Depoortere I., and Peeters T.L. Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut 54 (2005) 1078-1084. The first extensive study of the effect of ghrelin agonists on gastric emptying in mice, demonstrating a bell-shaped dose-response curve that should be kept in mind when planning applications.
    • (2005) Gut , vol.54 , pp. 1078-1084
    • Kitazawa, T.1    De Smet, B.2    Verbeke, K.3    Depoortere, I.4    Peeters, T.L.5
  • 25
    • 20344388544 scopus 로고    scopus 로고
    • Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
    • Depoortere I., De Winter B., Thijs T., De Man J., Pelckmans P., and Peeters T. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur J Pharmacol 515 (2005) 160-168
    • (2005) Eur J Pharmacol , vol.515 , pp. 160-168
    • Depoortere, I.1    De Winter, B.2    Thijs, T.3    De Man, J.4    Pelckmans, P.5    Peeters, T.6
  • 27
    • 0037404479 scopus 로고    scopus 로고
    • Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum
    • Depoortere I., Thijs T., Thielemans L., Robberecht P., and Peeters T.L. Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum. J Pharmacol Exp Ther 305 (2003) 660-667
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 660-667
    • Depoortere, I.1    Thijs, T.2    Thielemans, L.3    Robberecht, P.4    Peeters, T.L.5
  • 29
    • 33644809274 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia
    • Nagaya N., Kojima M., and Kangawa K. Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia. Intern Med 45 (2006) 127-134
    • (2006) Intern Med , vol.45 , pp. 127-134
    • Nagaya, N.1    Kojima, M.2    Kangawa, K.3
  • 31
    • 0027141042 scopus 로고
    • Erythromycin and other macrolides as prokinetic agents
    • Peeters T.L. Erythromycin and other macrolides as prokinetic agents. Gastroenterology 105 (1993) 1886-1899
    • (1993) Gastroenterology , vol.105 , pp. 1886-1899
    • Peeters, T.L.1
  • 35
    • 23844433696 scopus 로고    scopus 로고
    • Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus
    • Poitras P., Polvino W.J., and Rocheleau B. Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus. Peptides 26 (2005) 1598-1601
    • (2005) Peptides , vol.26 , pp. 1598-1601
    • Poitras, P.1    Polvino, W.J.2    Rocheleau, B.3
  • 38
    • 33644960738 scopus 로고    scopus 로고
    • New motilin agonists: a long and winding road
    • Peeters T.L. New motilin agonists: a long and winding road. Neurogastroenterol Motil 18 (2006) 1-5
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 1-5
    • Peeters, T.L.1
  • 39
    • 0034873597 scopus 로고    scopus 로고
    • What comes after macrolides and other motilin stimulants?
    • Tack J., and Peeters T. What comes after macrolides and other motilin stimulants?. Gut 49 (2001) 317-318
    • (2001) Gut , vol.49 , pp. 317-318
    • Tack, J.1    Peeters, T.2
  • 44
    • 33645080691 scopus 로고    scopus 로고
    • Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs
    • Ohno T., Kamiyama Y., Aihara R., Nakabayashi T., Mochiki E., Asao T., and Kuwano H. Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs. Neurogastroenterol Motil 18 (2006) 129-135
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 129-135
    • Ohno, T.1    Kamiyama, Y.2    Aihara, R.3    Nakabayashi, T.4    Mochiki, E.5    Asao, T.6    Kuwano, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.