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Volumn 26, Issue 8, 2003, Pages 743-747

Rapid desensitisation of the GH secretagogue (ghrelin) receptor to hexarelin in vitro

Author keywords

Calcium; Desensitisation; GH secretagogues; Ghrelin; Ghrelin receptor; GHS; GHS receptor; Hexarelin

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; COMPLEMENTARY DNA; FURA 2; GHRELIN; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE SECRETAGOGUE DERIVATIVE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; HEXARELIN; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 0344013162     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347357     Document Type: Article
Times cited : (20)

References (33)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 2
    • 0026513232 scopus 로고
    • From ligand binding to gene expression: New insights into the regulation of G-protein-coupled receptors
    • Collins S, CAron MG, Lefkowitz RJ. From ligand binding to gene expression: New insights into the regulation of G-protein-coupled receptors. Trends Biochem Sci 1992, 17: 37-9.
    • (1992) Trends Biochem Sci , vol.17 , pp. 37-39
    • Collins, S.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 3
    • 0021202398 scopus 로고
    • The effects of growth hormone (GH)-releasing peptides on GH secretion in perifused pituitary cells of adult male rats
    • Badger TM, Millard WJ, McMormick GF, Bowers CY, Martin JB. The effects of growth hormone (GH)-releasing peptides on GH secretion in perifused pituitary cells of adult male rats. Endocrinology 1984, 115: 1432-8.
    • (1984) Endocrinology , vol.115 , pp. 1432-1438
    • Badger, T.M.1    Millard, W.J.2    McMormick, G.F.3    Bowers, C.Y.4    Martin, J.B.5
  • 4
    • 0030945349 scopus 로고    scopus 로고
    • Growth hormone releasing peptides: A comparison of the growth hormone releasing peptides: A comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells
    • Cheng J, Wu TJ, Butler B, Cheng K. Growth hormone releasing peptides: A comparison of the growth hormone releasing peptides: A comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells. Life Sci 1997; 60: 1385-92.
    • (1997) Life Sci , vol.60 , pp. 1385-1392
    • Cheng, J.1    Wu, T.J.2    Butler, B.3    Cheng, K.4
  • 6
    • 0026016294 scopus 로고
    • Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites
    • Blake AD, Smith RG. Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites. J Endocrinol 1991, 129: 11-9.
    • (1991) J Endocrinol , vol.129 , pp. 11-19
    • Blake, A.D.1    Smith, R.G.2
  • 7
    • 0029994796 scopus 로고    scopus 로고
    • Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children
    • Klinger B, Sibergeld A, Deghenghi R, Frenkel J, Laron Z. Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children. Eur J Endocrinol 1996, 134: 716-9.
    • (1996) Eur J Endocrinol , vol.134 , pp. 716-719
    • Klinger, B.1    Sibergeld, A.2    Deghenghi, R.3    Frenkel, J.4    Laron, Z.5
  • 8
    • 0031724499 scopus 로고    scopus 로고
    • Growth hormone status during long-term hexarelin therapy
    • Rahim A, O'Neill PA, Shalet SM. Growth hormone status during long-term hexarelin therapy. J Clin Endocrinol Metab 1998; 83: 1644-9.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1644-1649
    • Rahim, A.1    O'Neill, P.A.2    Shalet, S.M.3
  • 9
    • 0344546950 scopus 로고    scopus 로고
    • Does desensitisation to growth hormone secretagogues occur?
    • In: Dieguez C, Ghigo E, Boghen MF, Casanueva FF eds; Rotterdam: Elsevier
    • Rahim A, Shalet SM. Does desensitisation to growth hormone secretagogues occur? In: Dieguez C, Ghigo E, Boghen MF, Casanueva FF eds. Growth Hormone Secretagogues: Basic Findings and Clinical Implications. Rotterdam: Elsevier 1999, 175-81.
    • (1999) Growth Hormone Secretagogues: Basic Findings and Clinical Implications , pp. 175-181
    • Rahim, A.1    Shalet, S.M.2
  • 10
    • 0033044313 scopus 로고    scopus 로고
    • Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon
    • Freir S, Weiss O, Eran M, et al. Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon. Gut 1999, 44: 704-8.
    • (1999) Gut , vol.44 , pp. 704-708
    • Freir, S.1    Weiss, O.2    Eran, M.3
  • 11
    • 0031059468 scopus 로고    scopus 로고
    • Regulatory mechanisms that modulate signalling by G-protein-coupled receptors
    • Bohm SK, Grady EF, Bunnett NW. Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J 1997, 322: 1-18.
    • (1997) Biochem J , vol.322 , pp. 1-18
    • Bohm, S.K.1    Grady, E.F.2    Bunnett, N.W.3
  • 12
    • 0029719789 scopus 로고    scopus 로고
    • Desensitization of G protein-coupled receptors
    • Freedman NJ, Lefkowitz RJ. Desensitization of G protein-coupled receptors. Recent Prog Horm Res 1996, 51: 319-51.
    • (1996) Recent Prog Horm Res , vol.51 , pp. 319-351
    • Freedman, N.J.1    Lefkowitz, R.J.2
  • 13
    • 15444346101 scopus 로고    scopus 로고
    • Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors
    • Korbonits M, Jacobs RA, Aylwin SBJ, et al. Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors. J Clin Endocrinol Metab 1998, 83: 3624-30.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3624-3630
    • Korbonits, M.1    Jacobs, R.A.2    Aylwin, S.B.J.3
  • 14
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985, 260: 3440-50.
    • (1985) J Biol Chem , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 15
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996, 273: 974-7.
    • (1996) Science , vol.273 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3
  • 16
    • 0025790152 scopus 로고
    • Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells
    • Cheng K, Chan WW, Butler B, Barreto Jr. A, Smith RG. Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells. Endocrinology 1991, 129: 3337-42.
    • (1991) Endocrinology , vol.129 , pp. 3337-3342
    • Cheng, K.1    Chan, W.W.2    Butler, B.3    Barreto Jr., A.4    Smith, R.G.5
  • 17
    • 0028037649 scopus 로고
    • Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotropes by 2 mechanisms
    • Herrington J, Hille B. Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotropes by 2 mechanisms. Endocrinology 1994, 135: 1100-8.
    • (1994) Endocrinology , vol.135 , pp. 1100-1108
    • Herrington, J.1    Hille, B.2
  • 18
    • 0028983836 scopus 로고
    • Central actions of peptide and non-peptide growth hormone secretagogues in the rat
    • Dickson SL, Leng G, Dyball REJ, Smith RG. Central actions of peptide and non-peptide growth hormone secretagogues in the rat. Neuroendocrinol 1995; 61: 36-43.
    • (1995) Neuroendocrinol , vol.61 , pp. 36-43
    • Dickson, S.L.1    Leng, G.2    Dyball, R.E.J.3    Smith, R.G.4
  • 19
    • 9844230970 scopus 로고    scopus 로고
    • Peptidomimetic regulation of growth hormone secretion
    • Smith RG, Van Der Ploeg LHT, Howard AD, et al. Peptidomimetic regulation of growth hormone secretion. Endocrine Rev 1997, 18: 621-45.
    • (1997) Endocrine Rev , vol.18 , pp. 621-645
    • Smith, R.G.1    Van Der Ploeg, L.H.T.2    Howard, A.D.3
  • 20
    • 0030028275 scopus 로고    scopus 로고
    • Identification of a new G-protein-linked receptor for growth hormone secretagogues
    • Pong SS, Chaung L-YP, Dean CD, et al. Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol Endocrinol 1996, 10: 57-61.
    • (1996) Mol Endocrinol , vol.10 , pp. 57-61
    • Pong, S.S.1    Chaung, L.-Y.P.2    Dean, C.D.3
  • 21
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic heptapeptide that acts on the pituitary to specifically release growth hormone
    • Bowers CY, Momany FA, Reynolds GA, Hong A. On the in vitro and in vivo activity of a new synthetic heptapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 1984, 114: 1537-45.
    • (1984) Endocrinology , vol.114 , pp. 1537-1545
    • Bowers, C.Y.1    Momany, F.A.2    Reynolds, G.A.3    Hong, A.4
  • 22
    • 0025809717 scopus 로고
    • On the actions of the growth hormone-releasing hexapeptide, GHRP
    • Bowers CY, Sartor AO, Reynolds GA, Badger TM. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 1991, 128: 2027-35.
    • (1991) Endocrinology , vol.128 , pp. 2027-2035
    • Bowers, C.Y.1    Sartor, A.O.2    Reynolds, G.A.3    Badger, T.M.4
  • 24
    • 0028884562 scopus 로고
    • Intranasal administration of the GHRP hexarelin accelerates growth in short children
    • Laron Z, Frenkel J, Deghenghi R, et al. Intranasal administration of the GHRP hexarelin accelerates growth in short children. Clin Endocrinol (Oxf) 1995, 43: 631-5.
    • (1995) Clin Endocrinol (Oxf) , vol.43 , pp. 631-635
    • Laron, Z.1    Frenkel, J.2    Deghenghi, R.3
  • 25
    • 0031759899 scopus 로고    scopus 로고
    • Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children
    • Mericq V, Cassorla F, Salazar T, et al. Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children. J Clin Endocrinol Metab 1998, 83: 2355-60.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2355-2360
    • Mericq, V.1    Cassorla, F.2    Salazar, T.3
  • 26
    • 0029074029 scopus 로고
    • Consistent GH responses to repeated injections of GH-releasing hexapeptide (GHRP-6) and the nonpeptide GH secretagogue, L-692,585
    • Fairhall KM, Mynett A, Smith RG, Robinson ICAF. Consistent GH responses to repeated injections of GH-releasing hexapeptide (GHRP-6) and the nonpeptide GH secretagogue, L-692,585. J Endocrinol 1995, 145: 417-26.
    • (1995) J Endocrinol , vol.145 , pp. 417-426
    • Fairhall, K.M.1    Mynett, A.2    Smith, R.G.3    Robinson, I.C.A.F.4
  • 27
    • 0025740899 scopus 로고
    • Growth hormone (GH) secretion during continuous infusion of GH-releasing peptide: Partial response attenuation
    • DeBell WK, Pezzoli SS, Thorner MO. Growth hormone (GH) secretion during continuous infusion of GH-releasing peptide: Partial response attenuation. J Clin Endocrinol Metab 191, 72, 1312-6.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1312-1316
    • DeBell, W.K.1    Pezzoli, S.S.2    Thorner, M.O.3
  • 28
    • 0027278470 scopus 로고
    • Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
    • Huhn WC, Hartman ML, Pezzoli SS, Thorner MO. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. J Clin Endocrinol Metab 1993, 76: 1202-8.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1202-1208
    • Huhn, W.C.1    Hartman, M.L.2    Pezzoli, S.S.3    Thorner, M.O.4
  • 29
    • 0027131717 scopus 로고
    • Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men
    • Jaffe CA, Ho PJ, Demott-Friberg R, Bowers CY, Barkan AL. Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men. J Clin Endocrinol Metab 1993, 77: 1641-7.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1641-1647
    • Jaffe, C.A.1    Ho, P.J.2    Demott-Friberg, R.3    Bowers, C.Y.4    Barkan, A.L.5
  • 30
    • 0031757867 scopus 로고    scopus 로고
    • A five day treatment with daily subcutaneous injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-I secretion in healthy young men
    • Nijland EA, Strasburger CJ, PoppSnijders C, VanderWal PS, Van Der Veen EA. A five day treatment with daily subcutaneous injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-I secretion in healthy young men. Eur J Endocrinol 1998, 139: 395-401.
    • (1998) Eur J Endocrinol , vol.139 , pp. 395-401
    • Nijland, E.A.1    Strasburger, C.J.2    PoppSnijders, C.3    VanderWal, P.S.4    Van Der Veen, E.A.5
  • 31
    • 0035044615 scopus 로고    scopus 로고
    • Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women
    • Murphy MG, Weiss S, McClung M, et al. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab 2001, 86: 1116-25.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1116-1125
    • Murphy, M.G.1    Weiss, S.2    McClung, M.3
  • 32
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002, 87: 2988.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2988
    • Gnanapavan, S.1    Kola, B.2    Bustin, S.A.3
  • 33
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003; 37: 649-61.
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3


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