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Volumn 44, Issue 10, 2006, Pages 594-604

Effect of postinjury intravenous or intrathecal methylprednisolone on spinal cord excitatory amino-acid release, nitric oxide generation, PGE 2 synthesis, and myeloperoxidase content in a pig model of acute spinal cord injury

Author keywords

Aspartate; Glutamate; Methylprednisolone; Myeloperoxidase; Nitric oxide; PGE2

Indexed keywords

ASPARTIC ACID; CITRULLINE; EXCITATORY AMINO ACID; GLUTAMIC ACID; METHYLPREDNISOLONE; MYELOPEROXIDASE; NITRIC OXIDE; PROSTAGLANDIN E2;

EID: 33750156013     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sj.sc.3101891     Document Type: Article
Times cited : (26)

References (50)
  • 1
  • 2
    • 0022224135 scopus 로고
    • Lipid hydrolysis and peroxidation in injured spinal cord: Partial protection with methylprednisolone or vitamin E and selenium
    • Anderson DK et al. Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Central Nerv Syst Trauma 1985; 2: 257-267.
    • (1985) Central Nerv Syst Trauma , vol.2 , pp. 257-267
    • Anderson, D.K.1
  • 3
    • 0023195163 scopus 로고
    • Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue
    • Saunders RD, Dugan LL, Demediuk P, Means ED, Horrocks LA, Anderson DK. Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue. J Neurochem 1987; 49: 24-31.
    • (1987) J Neurochem , vol.49 , pp. 24-31
    • Saunders, R.D.1    Dugan, L.L.2    Demediuk, P.3    Means, E.D.4    Horrocks, L.A.5    Anderson, D.K.6
  • 4
    • 0027285503 scopus 로고
    • Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury
    • Liu D, McAdoo DJ. Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury. Brain Res 1993; 609: 293-297.
    • (1993) Brain Res , vol.609 , pp. 293-297
    • Liu, D.1    McAdoo, D.J.2
  • 5
    • 0030049084 scopus 로고    scopus 로고
    • Effects of methylprednisolone on extracellular lactic acidosis and amino acids after severe compression injury of rat spinal cord
    • Farooque M, Hillered L, Holtz A, Olsson Y. Effects of methylprednisolone on extracellular lactic acidosis and amino acids after severe compression injury of rat spinal cord. J Neurochem 1996; 66: 1125-1130.
    • (1996) J Neurochem , vol.66 , pp. 1125-1130
    • Farooque, M.1    Hillered, L.2    Holtz, A.3    Olsson, Y.4
  • 6
    • 0034999442 scopus 로고    scopus 로고
    • Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: A site of the neuroprotective action of methylprednisolone
    • Liu D, Li L, Augustus L. Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone. J Neurochem 2001; 77: 1036-1047.
    • (2001) J Neurochem , vol.77 , pp. 1036-1047
    • Liu, D.1    Li, L.2    Augustus, L.3
  • 7
    • 0036367655 scopus 로고    scopus 로고
    • Efficacy of methylprednisolone in acute experimental cauda equina injury
    • discussion 821
    • Gok A, Uk C, Yilmaz M, Bakir K, Erkutlu I, Alptekin M. Efficacy of methylprednisolone in acute experimental cauda equina injury. Acta Neurochir (Wien) 2002; 144: 817-821 (discussion 821).
    • (2002) Acta Neurochir (Wien) , vol.144 , pp. 817-821
    • Gok, A.1    Uk, C.2    Yilmaz, M.3    Bakir, K.4    Erkutlu, I.5    Alptekin, M.6
  • 8
    • 0030273305 scopus 로고    scopus 로고
    • The effects of taxol, methylprednisolone, and 4-aminopyridine in compressive spinal cord injury: A qualitative experimental study
    • Perez-Espejo MA, Haghighi SS, Adelstein EH, Madsen R. The effects of taxol, methylprednisolone, and 4-aminopyridine in compressive spinal cord injury: a qualitative experimental study. Surg Neurol 1996; 46: 350-357.
    • (1996) Surg Neurol , vol.46 , pp. 350-357
    • Perez-Espejo, M.A.1    Haghighi, S.S.2    Adelstein, E.H.3    Madsen, R.4
  • 9
    • 0028293108 scopus 로고
    • Modeling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673
    • Behrmann DL, Bresnahan JC, Beattie MS. Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp Neurol 1994; 126: 61-75.
    • (1994) Exp Neurol , vol.126 , pp. 61-75
    • Behrmann, D.L.1    Bresnahan, J.C.2    Beattie, M.S.3
  • 10
    • 0028326586 scopus 로고
    • Effect of the 21-aminosteroid U74006F and methylprednisolone on motor function recovery and oedema after spinal cord compression in rats
    • Farooque M, Olsson Y, Holtz A. Effect of the 21-aminosteroid U74006F and methylprednisolone on motor function recovery and oedema after spinal cord compression in rats. Acta Neurol Scand 1994; 89: 36-41.
    • (1994) Acta Neurol Scand , vol.89 , pp. 36-41
    • Farooque, M.1    Olsson, Y.2    Holtz, A.3
  • 11
    • 0025032726 scopus 로고
    • Effect of methylprednisolone on motor function and spinal cord blood flow after spinal cord compression in rats
    • Holtz A, Nystrom B, Gerdin B. Effect of methylprednisolone on motor function and spinal cord blood flow after spinal cord compression in rats. Acta Neurol Scand 1990; 82: 68-73.
    • (1990) Acta Neurol Scand , vol.82 , pp. 68-73
    • Holtz, A.1    Nystrom, B.2    Gerdin, B.3
  • 12
    • 0022366322 scopus 로고
    • Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study
    • Bracken MB et al. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. J Neurosurg 1985; 63: 704-713.
    • (1985) J Neurosurg , vol.63 , pp. 704-713
    • Bracken, M.B.1
  • 13
    • 0025344617 scopus 로고
    • A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study
    • Bracken MB et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990; 322: 1405-1411.
    • (1990) N Engl J Med , vol.322 , pp. 1405-1411
    • Bracken, M.B.1
  • 14
    • 0026601887 scopus 로고
    • Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-Year follow-up data. Results of the second National Acute Spinal Cord Injury Study
    • Bracken MB et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg 1992; 76: 23-31.
    • (1992) J Neurosurg , vol.76 , pp. 23-31
    • Bracken, M.B.1
  • 15
    • 1642422176 scopus 로고    scopus 로고
    • Administration of methylprednisolone for 24 or 48 h or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study
    • Bracken MB et al. Administration of methylprednisolone for 24 or 48 h or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997; 277: 1597-1604.
    • (1997) JAMA , vol.277 , pp. 1597-1604
    • Bracken, M.B.1
  • 16
    • 17144468967 scopus 로고    scopus 로고
    • Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-Year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial
    • Bracken MB et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 1998; 89: 699-706.
    • (1998) J Neurosurg , vol.89 , pp. 699-706
    • Bracken, M.B.1
  • 17
    • 0036128846 scopus 로고    scopus 로고
    • Neurological and functional status 1 year after acute spinal cord injury: Estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III
    • Bracken MB, Holford TR. Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III. J Neurosurg Spine 2002; 96: 259-266.
    • (2002) J Neurosurg Spine , vol.96 , pp. 259-266
    • Bracken, M.B.1    Holford, T.R.2
  • 18
    • 0034104861 scopus 로고    scopus 로고
    • Pharmacological therapy of spinal cord injury during the acute phase
    • Pointillart V et al. Pharmacological therapy of spinal cord injury during the acute phase. Spinal Cord 2000; 38: 71-76.
    • (2000) Spinal Cord , vol.38 , pp. 71-76
    • Pointillart, V.1
  • 19
    • 0031409984 scopus 로고    scopus 로고
    • An evaluation of the factors affecting neurological recovery following spinal cord injury
    • Poynton AR, O'Farrell DA, Shannon F, Murray P, McManus F, Walsh MG. An evaluation of the factors affecting neurological recovery following spinal cord injury. Injury 1997; 28: 545-548.
    • (1997) Injury , vol.28 , pp. 545-548
    • Poynton, A.R.1    O'Farrell, D.A.2    Shannon, F.3    Murray, P.4    McManus, F.5    Walsh, M.G.6
  • 20
    • 0031050315 scopus 로고    scopus 로고
    • Consequences of high-dose steroid therapy for acute spinal cord injury
    • Gerndt SJ et al. Consequences of high-dose steroid therapy for acute spinal cord injury. J Trauma 1997; 42: 279-284.
    • (1997) J Trauma , vol.42 , pp. 279-284
    • Gerndt, S.J.1
  • 23
    • 0028099683 scopus 로고
    • High-performance liquid chromatographic analysis of synthetic peptides using derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate
    • De Antonis KM, Brown PR, Cohen SA. High-performance liquid chromatographic analysis of synthetic peptides using derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Anal Biochem 1994; 223: 191-197.
    • (1994) Anal Biochem , vol.223 , pp. 191-197
    • De Antonis, K.M.1    Brown, P.R.2    Cohen, S.A.3
  • 24
    • 0027305020 scopus 로고
    • Synthesis of a fluorescent derivatizing reagent, 6-aminoquinolyl-N- hydroxysuccinimidyl carbamate, and its application for the analysis of hydrolysate amino acids via high-performance liquid chromatography
    • Cohen SA, Michaud DP. Synthesis of a fluorescent derivatizing reagent, 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate, and its application for the analysis of hydrolysate amino acids via high-performance liquid chromatography. Anal Biochem 1993; 211: 279-287.
    • (1993) Anal Biochem , vol.211 , pp. 279-287
    • Cohen, S.A.1    Michaud, D.P.2
  • 25
    • 0029157657 scopus 로고
    • Lack of effect of postinjury treatment with methylprednisolone or tirilazad mesylate on the increase in eicosanoid levels in the acutely injured cat spinal cord
    • Hall ED, Yonkers PA, Taylor BM, Sun FF. Lack of effect of postinjury treatment with methylprednisolone or tirilazad mesylate on the increase in eicosanoid levels in the acutely injured cat spinal cord. J Neurotrauma 1995; 12: 245-256.
    • (1995) J Neurotrauma , vol.12 , pp. 245-256
    • Hall, E.D.1    Yonkers, P.A.2    Taylor, B.M.3    Sun, F.F.4
  • 26
    • 0033793219 scopus 로고    scopus 로고
    • The role of reactive nitrogen species in secondary spinal cord injury: Formation of nitric oxide, peroxynitrite, and nitrated protein
    • Liu D, Ling X, Wen J, Liu J. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 2000; 75: 2144-2154.
    • (2000) J Neurochem , vol.75 , pp. 2144-2154
    • Liu, D.1    Ling, X.2    Wen, J.3    Liu, J.4
  • 27
    • 18744418274 scopus 로고    scopus 로고
    • Superoxide production after spinal injury detected by microperfusion of cytochrome c
    • Liu D, Sybert TE, Qian H, Liu J. Superoxide production after spinal injury detected by microperfusion of cytochrome c. Free Radic Biol Med 1998; 25: 298-304.
    • (1998) Free Radic Biol Med , vol.25 , pp. 298-304
    • Liu, D.1    Sybert, T.E.2    Qian, H.3    Liu, J.4
  • 28
    • 0036907529 scopus 로고    scopus 로고
    • The increase of reactive oxygen species and their inhibition in an isolated guinea pig spinal cord compression model
    • Luo J, Li N, Robinson JP, Shi R. The increase of reactive oxygen species and their inhibition in an isolated guinea pig spinal cord compression model. Spinal Cord 2002; 40: 656-665.
    • (2002) Spinal Cord , vol.40 , pp. 656-665
    • Luo, J.1    Li, N.2    Robinson, J.P.3    Shi, R.4
  • 29
    • 17444427385 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury
    • Xu W et al. Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord 2005; 43: 204-213.
    • (2005) Spinal Cord , vol.43 , pp. 204-213
    • Xu, W.1
  • 31
    • 0030990083 scopus 로고    scopus 로고
    • Calcium-dependent and calcium-independent activation of the endothelial NO synthase
    • Fleming I, Bauersachs J, Busse R. Calcium-dependent and calcium-independent activation of the endothelial NO synthase. J Vasc Res 1997; 34: 165-174.
    • (1997) J Vasc Res , vol.34 , pp. 165-174
    • Fleming, I.1    Bauersachs, J.2    Busse, R.3
  • 32
    • 0030615095 scopus 로고    scopus 로고
    • 2+-dependent NO-production from central nervous system cells in culture measured by NO-nitrite/ozone chemoluminescence
    • 2+-dependent NO-production from central nervous system cells in culture measured by NO-nitrite/ozone chemoluminescence. Brain Res 1997; 748: 1-11.
    • (1997) Brain Res , vol.748 , pp. 1-11
    • Weikert, S.1
  • 33
    • 0141624363 scopus 로고    scopus 로고
    • White matter injury mechanisms
    • Stys PK. White matter injury mechanisms. Curr Mol Med 2004; 4: 113-130.
    • (2004) Curr Mol Med , vol.4 , pp. 113-130
    • Stys, P.K.1
  • 34
    • 0032791163 scopus 로고    scopus 로고
    • Neurotoxicity of glutamate at the concentration released upon spinal cord injury
    • Liu D, Xu GY, Pan E, McAdoo DJ. Neurotoxicity of glutamate at the concentration released upon spinal cord injury. Neuroscience 1999; 93: 1383-1389.
    • (1999) Neuroscience , vol.93 , pp. 1383-1389
    • Liu, D.1    Xu, G.Y.2    Pan, E.3    McAdoo, D.J.4
  • 35
    • 0031046652 scopus 로고    scopus 로고
    • Effects of moderate hypothermia on extracellular lactic acid and amino acids after severe compression injury of rat spinal cord
    • Farooque M, Hillered L, Holtz A, Olsson Y. Effects of moderate hypothermia on extracellular lactic acid and amino acids after severe compression injury of rat spinal cord. J Neurotrauma 1997; 14: 63-69.
    • (1997) J Neurotrauma , vol.14 , pp. 63-69
    • Farooque, M.1    Hillered, L.2    Holtz, A.3    Olsson, Y.4
  • 36
    • 0031035166 scopus 로고    scopus 로고
    • Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord
    • Farooque M, Hillered L, Holtz A, Olsson Y. Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord. Exp Brain Res 1997; 113: 1-4.
    • (1997) Exp Brain Res , vol.113 , pp. 1-4
    • Farooque, M.1    Hillered, L.2    Holtz, A.3    Olsson, Y.4
  • 37
    • 0029914112 scopus 로고    scopus 로고
    • Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: An experimental study in the rat using microdialysis
    • Farooque M, Hillered L, Holtz A, Olsson Y. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. J Neurotrauma 1996; 13: 537-548.
    • (1996) J Neurotrauma , vol.13 , pp. 537-548
    • Farooque, M.1    Hillered, L.2    Holtz, A.3    Olsson, Y.4
  • 38
    • 2342550091 scopus 로고    scopus 로고
    • Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord
    • Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ. Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord. Exp Neurol 2004; 187: 329-336.
    • (2004) Exp Neurol , vol.187 , pp. 329-336
    • Xu, G.Y.1    Hughes, M.G.2    Ye, Z.3    Hulsebosch, C.E.4    McAdoo, D.J.5
  • 39
    • 0037039534 scopus 로고    scopus 로고
    • Rapid changes in expression of glutamate transporters after spinal cord injury
    • Vera-Portocarrero LP et al. Rapid changes in expression of glutamate transporters after spinal cord injury. Brain Res 2002; 927: 104-110.
    • (2002) Brain Res , vol.927 , pp. 104-110
    • Vera-Portocarrero, L.P.1
  • 40
    • 0034727410 scopus 로고    scopus 로고
    • AIDA reduces glutamate release and attenuates mechanical allodynia after spinal cord injury
    • Mills CD et al. AIDA reduces glutamate release and attenuates mechanical allodynia after spinal cord injury. Neuroreport 2000; 11: 3067-3070.
    • (2000) Neuroreport , vol.11 , pp. 3067-3070
    • Mills, C.D.1
  • 41
    • 0034063626 scopus 로고    scopus 로고
    • Role of leukocytes in spinal cord injury in rats
    • Taoka Y, Okajima K. Role of leukocytes in spinal cord injury in rats. J Neurotrauma 2000; 17: 219-229.
    • (2000) J Neurotrauma , vol.17 , pp. 219-229
    • Taoka, Y.1    Okajima, K.2
  • 42
    • 0030845563 scopus 로고    scopus 로고
    • Role of neutrophils in spinal cord injury in the rat
    • Taoka Y et al. Role of neutrophils in spinal cord injury in the rat. Neuroscience 1997; 79: 1177-1182.
    • (1997) Neuroscience , vol.79 , pp. 1177-1182
    • Taoka, Y.1
  • 43
    • 0038101299 scopus 로고    scopus 로고
    • Prostaglandin E1 reduces compression trauma-induced spinal cord injury in rats mainly by inhibiting neutrophil activation
    • Naruo S et al. Prostaglandin E1 reduces compression trauma-induced spinal cord injury in rats mainly by inhibiting neutrophil activation. J Neurotrauma 2003; 20: 221-228.
    • (2003) J Neurotrauma , vol.20 , pp. 221-228
    • Naruo, S.1
  • 44
    • 0026470092 scopus 로고
    • A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-eukocyte adhesion molecule 1 and intercellular adhesion molecule 1
    • Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G. A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-eukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89: 9991-9995.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9991-9995
    • Cronstein, B.N.1    Kimmel, S.C.2    Levin, R.I.3    Martiniuk, F.4    Weissmann, G.5
  • 45
    • 0030741887 scopus 로고    scopus 로고
    • Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils
    • Filep JG, Delalandre A, Payette Y, Foldes-Filep E. Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils. Circulation 1997; 96: 295-301.
    • (1997) Circulation , vol.96 , pp. 295-301
    • Filep, J.G.1    Delalandre, A.2    Payette, Y.3    Foldes-Filep, E.4
  • 46
    • 0036131321 scopus 로고    scopus 로고
    • Complications associated with the prophylactic use of methylprednisolone during surgical stabilization after spinal cord injury
    • Molano Mdel R, Broton JG, Bean JA, Calancie B. Complications associated with the prophylactic use of methylprednisolone during surgical stabilization after spinal cord injury. J Neurosurg Spine 2002; 96: 267-272.
    • (2002) J Neurosurg Spine , vol.96 , pp. 267-272
    • Molano Mdel, R.1    Broton, J.G.2    Bean, J.A.3    Calancie, B.4
  • 47
    • 2942722478 scopus 로고    scopus 로고
    • Acute traumatic spinal cord injury, 1993-2000A population-based assessment of methylprednisolone administration and hospitalization
    • McCutcheon EP, Selassie AW, Gu JK, Pickelsimer EE. Acute traumatic spinal cord injury, 1993-2000A population-based assessment of methylprednisolone administration and hospitalization. J Trauma 2004; 56: 1076-1083.
    • (2004) J Trauma , vol.56 , pp. 1076-1083
    • McCutcheon, E.P.1    Selassie, A.W.2    Gu, J.K.3    Pickelsimer, E.E.4
  • 48
    • 0035865654 scopus 로고    scopus 로고
    • Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury
    • Matsumoto T, Tamaki T, Kawakami M, Yoshida M, Ando M, Yamada H. Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury. Spine 2001; 26: 426-430.
    • (2001) Spine , vol.26 , pp. 426-430
    • Matsumoto, T.1    Tamaki, T.2    Kawakami, M.3    Yoshida, M.4    Ando, M.5    Yamada, H.6
  • 49
    • 0027423622 scopus 로고
    • The two-edged sword of large-dose steroids for spinal cord trauma
    • discussion 425-427
    • Galandiuk S, Raque G, Appel S, Polk Jr HC. The two-edged sword of large-dose steroids for spinal cord trauma. Ann Surg 1993; 218: 419-425; (discussion 425-427).
    • (1993) Ann Surg , vol.218 , pp. 419-425
    • Galandiuk, S.1    Raque, G.2    Appel, S.3    Polk Jr., H.C.4
  • 50
    • 0033961357 scopus 로고    scopus 로고
    • Spinal cord bioavailability of methylprednisolone after intravenous and intrathecal administration: The role of P-glycoprotein
    • Koszdin KL, Shen DD, Bernards CM. Spinal cord bioavailability of methylprednisolone after intravenous and intrathecal administration: the role of P-glycoprotein. Anesthesiology 2000; 92: 156-163.
    • (2000) Anesthesiology , vol.92 , pp. 156-163
    • Koszdin, K.L.1    Shen, D.D.2    Bernards, C.M.3


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