Prostaglandin E1 reduces compression trauma-induced spinal cord injury in rats mainly by inhibiting neutrophil activation

Journal of Neurotrauma

Volumn 20, Issue 2, 2003, Pages 221-228

  Naruo, Seiichiro ^a   Okajima, Kenji ^a   Taoka, Yuji ^a,b   Uchiba, Mitsuhiro ^a   Nakamura, Takafumi ^a   Okabe, Hiroaki ^a   Takagi, Katsumasa ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Motor disturbances; Neutrophils; Prostaglandin E1; Spinal cord injury; Tumor necrosis factor alpha

Indexed keywords

CYTOKINE; MYELOPEROXIDASE; PROSTAGLANDIN E1; TUMOR NECROSIS FACTOR ALPHA; PEROXIDASE; VASODILATOR AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG INFUSION; ENZYME ASSAY; EXPERIMENTAL MODEL; IMMUNE RESPONSE; LEUKOCYTE ACTIVATION; NONHUMAN; RAT; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; VASODILATATION; ANIMAL; BLUNT TRAUMA; DRUG EFFECT; MALE; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL CORD; WISTAR RAT;

ALPROSTADIL; ANIMALS; MALE; MOTOR ACTIVITY; NEUTROPHIL ACTIVATION; PEROXIDASE; RATS; RATS, WISTAR; SPINAL CORD; SPINAL CORD INJURIES; TUMOR NECROSIS FACTOR-ALPHA; VASODILATOR AGENTS; WOUNDS, NONPENETRATING;

EID: 0038101299     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/08977150360547125     Document Type: Article

References (39)

1. 1 induced hypotension. Prostaglandins Leukot. Essent. Fatty Acids. 51, 173-176.
2. BLIGHT, A.R. (1992). Spinal cord injury models: neurophysiology. J. Neurotrauma 9, 147-149.
3. BRACKEN, M.B., SHEPARD, M.J., COLLINS, W.F., et al. (1990). A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N. Engl. J. Med. 322, 1405-1411.
4. CAGGIANO, A.O., and KRAIG, R.P. (1999). Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production. J. Neurochem. 72, 565-575.
5. CARLOS, T.M., and HARLAN, J.M. (1994). Leukocyte-endothelial adhesion molecules. Blood 84, 2068-2101.
6. 1 on microcirculation of rat cremaster muscle. Microsurgery 11, 204-208.
7. 1 as a pharmacoangiographic agent for arterial portography. Radiology 116, 207-209.
8. HAMADA, Y., IKATA, T., KATOH, S., et al. (1996). Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats. J. Neurochem. 66, 1525-1531.
9. HARLAN, J.M. (1987). Consequences of leukocyte-vessel wall interactions in inflammatory and immune reactions. Semin. Thromb. Hemost. 13, 434-444.
10. 1 suppress tumor necrosis factor-α and interleukin-10 production by lipopolysaccharides-stimulated mononuclear cells. Eur. J. Pharmacol. 344, 95-98.
11. 1 prevents apoptotic cell death in superficial dorsal horn of rat spinal cord. Neuropharmacology 36, 1023-1030.
12. KLEBANOFF, S.J., VADAS, M.A., HARLAN, J.M., et al. (1986). Stimulation of neutrophils by tumor necrosis factor. J. Immunol. 36, 4220-4225.
13. KOMATSU, Y., SHIRATORI, Y., KAWASE, T., et al. (1994). Role of polymorphonuclear leukocytes in galactosamine hepatitis: mechanism of adherence to hepatic endothelial cells. Hepatology 20, 1548-1556.
14. KUNKEL-BAGDEN, E., DAI, H.N., and BREGMAN, B.S. (1993). Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp. Neurol. 119, 153-164.
15. LALLI, E., and SASSONE-CORSI, P. (1994). Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem. 269, 17359-17362.
16. LIU, W., OKAJMA, K., MURAKAMI, K., et al. (1998). Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. J. Lab. Clin. Med. 132, 432-439.
17. 1. Hepatology 27, 822-828.
18. 1 infusion on limb hemodynamics and vasodilatory response in patients with arteriosclerosis obliterans. Cardiovasc. Drugs Ther. 11, 441-448.
19. 1 on blood flow to the gastric tube after esophagectomy. Ann. Thorac. Surg. 67, 908-910.
20. MEANS, E.D., and ANDERSON, D.K. (1983). Neuronophagia by leukocytes in experimental spinal cord injury. J. Neuropathol. Exp. Neurol. 42, 707-719.
21. MULLIGAN, M.S., VARANI, J., DAME, M.K., et al. (1991). Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J. Clin. Invest. 88, 1396-1406.
22. OH-ISHI, S., UTSUNOMIYA, I., YAMAMOTO, T., et al. (1996). Effects of prostaglandins and cyclic AMP on cytokine production in rat leukocytes. Eur. J. Pharmacol. 300, 255-259.
23. 1 on the release of neutrophil elastase from FMLP-stimulated neutrophils. J. Med. 22, 371-382.
24. κB-mediated transcription in human monocytic cells and endothelial cells. J. Biol. Chem. 271, 20828-20835.
25. 1-therapy reduces circulating adhesion molecules (ICAM-1, E-selectin, VCAM-1) in peripheral vascular disease. Vasa 29, 179-185.
26. PETROVA, T.V., AKAMA, K.T., and VAN ELDIK, L.J. (1999). Selective modulation of BV-2 microglial activation by prostaglandin E(2). Differential effects on endotoxin-stimulated cytokine induction. J. Biol. Chem. 274, 28823-28827.
27. 2, indomethacin, histamine, and tuftsin on chemiluminescence response of bovine polymorphonuclear leukocytes. Vet. Immunol. Immunopathol. 14, 233-244.
28. RIVLIN, A.S., and TATOR, C.H. (1977). Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47, 577-581.
29. 1 on lipopolysaccharide-evoked responses in vivo and in vitro following resuscitated trauma. Shock 3, 307-314.
30. SUTTORP, N., SEEGER, W., ZUCKER-REIMANN,'J., et al. (1987). Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin. Infect Immunol. 55, 104-110.
31. TAOKA, Y., NARUO, M., KOYANAGI, E., et al. (1995). Superoxide radicals play important roles in the pathogenesis of spinal cord injury. Paraplegia 33, 450-453.
32. TAOKA, Y., OKAJIMA, K., UCHIBA, M., et al. (1997a). Role of neutrophils in spinal cord injury in the rat. Neuroscience 79, 1177-1182.
33. TAOKA Y, OKAJIMA K, UCHIBA M, et al. (1997b) Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog. J. Neurosurg. 86, 1007-1011.
34. TAOKA, Y., OKAJIMA, K., UCHIBA, M., et al. (1998a). Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes. J. Neuroscience 18, 1393-1398.
35. TAOKA, Y., and OKAJIMA, K. (1998b). Spinal cord injury in the rat. Prog. Neurobiol. 56, 341-358.
36. TAOKA, Y., OKAJIMA, K., MURAKAMI, K., et al. (1998c). Role of neutrophil elastase in compression-induced spinal cord injury in rats. Brain Res. 20, 264-269.
37. TAOKA, Y., OKAJIMA, K., UCHIBA, M., et al. (2001). Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-alpha production. J. Neurotrauma 18, 533-543.
38. WONG, K., and FREUND, K. (1981). Inhibition of the n-formylmethionyl-leucyl-phenylalanine induced respiratory burst in human neutrophils by adrenergic agonists and prostaglandins of the E series. (1981). Can. J. Physiol. Pharmacol. 59, 915-920.
39. XU, J.A., HSU, C.Y., LIU, T.H., et al. (1990). Leukotriene B4 release and polymorphonuclear cell infiltration in spinal cord injury. J. Neurochem. 55, 907-912.