Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7816-7825

  Zhao, Xue Zhi ^a   Semenova, Elena A ^b   Liao, Chenzhong ^a   Nicklaus, Marc ^a   Pommier, Yves ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Biotin; HIV 1 integrase; Inhibitor; Photoaffinity

Indexed keywords

2,4 DIOXOBUTANOIC ACID; BUTYRIC ACID; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CROSS LINKING; CYCLOADDITION; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; DRUG DETERMINATION; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; IC 50; MOLECULAR PROBE; PHARMACOPHORE; PHOTOAFFINITY LABELING; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ACETOACETATES; ANTI-HIV AGENTS; BINDING SITES; BIOTINYLATION; BIPHENYL COMPOUNDS; CROSS-LINKING REAGENTS; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; PHOTOAFFINITY LABELS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750070340     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.064     Document Type: Article

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