Functional characterization of the modified melanocortin peptides responsible for ligand selectivity at the human melanocortin receptors

Peptides

Volumn 27, Issue 11, 2006, Pages 2836-2845

  Chen, Min ^a   Georgeson, Keith E ^a   Harmon, Carroll M ^a   Haskell Luevano, Carrie ^b   Yang, Yingkui ^a  

^a Kentucky   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

GPCR; MC3R; MC4R; Obesity; SHU9119

Indexed keywords

ALPHA INTERMEDIN DERIVATIVE; CYCLIC AMP; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; TETRAPEPTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; EMBRYO; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN MODIFICATION; STEREOCHEMISTRY; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL LINE; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MELANOCORTINS; MELANOCYTE-STIMULATING HORMONES; MOLECULAR SEQUENCE DATA; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, MELANOCORTIN;

EID: 33750057422     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.04.012     Document Type: Article

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