Development of a New Family of Conformationally Restricted Peptides as Potent Nucleators of β-Turns. Design, Synthesis, Structure, and Biological Evaluation of β-Lactam Peptide Analogue of Melanostatin

Journal of the American Chemical Society

Volumn 125, Issue 52, 2003, Pages 16243-16260

  Palomo, Claudio ^a   Aizpurua, Jesus M ^a   Benito, Ana ^a   Miranda, José Ignacio ^a   Fratila, Raluca M ^a   Matute, Carlos ^a   Domercq, Maria ^a   Gago, Federico ^b   Martin Santamaria, Sonsoles ^b   Linden, Anthony ^c  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; ANNEALING; BIOASSAY; CELL CULTURE; COMPUTER SIMULATION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

POTENT NUCLEATORS;

CONFORMATIONS;

BETA LACTAM DERIVATIVE; DIMETHYL SULFOXIDE; DOPAMINE 2 RECEPTOR; DRUG DERIVATIVE; LACTAM; MELANOSTATIN; OLIGOPEPTIDE; PSEUDOPEPTIDE; TETRAPEPTIDE;

ALKYLATION; ANIMAL; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONFORMATION; DRUG DESIGN; DRUG POTENTIATION; MOLECULAR DYNAMICS; MOLECULAR STABILITY; NERVE CELL; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTEIN FAMILY; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RAT; SIMULATION; STEREOCHEMISTRY; STEREOISOMERISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BETA-LACTAMS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; MSH RELEASE-INHIBITING HORMONE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, DOPAMINE D2; STEREOISOMERISM;

EID: 9144267831     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja038180a     Document Type: Article

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