Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7716-7727

  Moreau, Anne ^a   Chen, Qiao Hong ^a   Praveen Rao, P N ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

(E) 3 (4 Methanesulfonylphenyl) 2 (phenyl or biphenyl)acrylic acids; Anti inflammatory activity; Dual cyclooxygenase lipoxygenase inhibitors

Indexed keywords

2 (3 BROMOPHENYL) 3 (4 METHANESULFONYLPHENYL)ACRYLIC ACID; ACETYLSALICYLIC ACID; ACRYLIC ACID DERIVATIVE; ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LIPOXYGENASE INHIBITOR; LUTEOLIN; PALLADIUM; PARACETAMOL; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL REACTION; DRUG DESIGN; DRUG POTENTIATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50;

ACRYLATES; ARACHIDONATE 5-LIPOXYGENASE; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; LIPOXYGENASE INHIBITORS; LUTEOLIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 33750052919     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.08.008     Document Type: Article

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