4,5-diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)

Medicinal Research Reviews

Volumn 19, Issue 3, 1999, Pages 199-208

  Talley, John J ^a   Bertenshaw, Stephen R ^a   Brown, David L ^a   Carter, Jeffery S ^a   Graneto, Mathew J ^a   Koboldt, Carol M ^a   Masferrer, Jaime L ^a   Norman, Bryan H ^a   Rogier Jr , D Joseph ^a   Zweifel, Ben S ^a   Seibert, Karen ^a  

^a PFIZER INC   (United States)

Author keywords

Anti inflammatory; COX 2; COX 2 inhibitors; Cyclooxygenase 2; Diaryloxazole; Inflammation

Indexed keywords

2 TRIFLUOROMETHYL 4,5 DIARYLOXAZOLE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PYRROLE DERIVATIVE; SC 299; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; DRUG ABSORPTION; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFLAMMATION; ISOMERISM; NONHUMAN; RAT; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; OXAZOLES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0032923346     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1128(199905)19:3<199::AID-MED1>3.0.CO;2-7     Document Type: Review

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24. Prepared by the reaction of the appropriate benzoin with trifluoroacetonitrile in the presence of base followed by chlorosulfonation and reaction of the sulfonyl chloride with aqueous ammonia.
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