메뉴 건너뛰기




Volumn 14, Issue 3, 2005, Pages 447-460

Elevated amyloid β protein (Aβ42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; LEUCINE; PLASMA PROTEIN; PLASMIN; PLASMINOGEN; PROLINE; UROKINASE;

EID: 13544273507     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddi041     Document Type: Article
Times cited : (63)

References (37)
  • 4
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner, G.G. and Wong, C.W. (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun., 122, 1131-1135.
    • (1984) Biochem. Biophys. Res. Commun. , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 5
    • 0028915895 scopus 로고
    • Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
    • Gravina, S.A., Ho, L., Eckman, C.B., Long, K.E., Otvos, L., Younkin, L.H., Suzuki, N. and Younkin, S.G. (1995) Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J. Biol. Chem., 270, 7013-7016.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7013-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3    Long, K.E.4    Otvos, L.5    Younkin, L.H.6    Suzuki, N.7    Younkin, S.G.8
  • 7
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
    • Suzuki, N., Cheung, T.T., Cai, X.D., Odaka, A., Otvos, L., Jr, Eckman, C., Golde, T.E. and Younkin, S.G. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science, 264, 1336-1340.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.D.3    Odaka, A.4    Otvos Jr., L.5    Eckman, C.6    Golde, T.E.7    Younkin, S.G.8
  • 10
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. and Cole, G. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science, 274, 99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 11
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T.D., Hardy, J., Hutton, M., Kukull, W. et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med., 2, 864-870.
    • (1996) Nat. Med. , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6    Bird, T.D.7    Hardy, J.8    Hutton, M.9    Kukull, W.10
  • 12
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
    • Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K, Lee, M., Seubert, P., Davis, A. et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med., 3, 67-72.
    • (1997) Nat. Med. , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3    Carlson, G.4    Diehl, T.5    Levesque, G.6    Johnson-Wood, K.7    Lee, M.8    Seubert, P.9    Davis, A.10
  • 13
    • 0028181436 scopus 로고
    • Solution structure of the kringle domain from urokinase-type plasminogen activator
    • Li, X., Bokman, A.M., Llinas, M., Smith, R.A. and Dobson, C.M. (1994) Solution structure of the kringle domain from urokinase-type plasminogen activator. J. Mol. Biol., 235, 1548-1559.
    • (1994) J. Mol. Biol. , vol.235 , pp. 1548-1559
    • Li, X.1    Bokman, A.M.2    Llinas, M.3    Smith, R.A.4    Dobson, C.M.5
  • 14
    • 0029969280 scopus 로고    scopus 로고
    • Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure
    • Yoshimoto, M., Ushiyama, Y., Sakai, M., Tamaki, S., Hara, H., Takahashi, K., Sawasaki, Y. and Hanada, K. (1996) Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure. Biochim. Biophys. Acta, 1293, 83-89.
    • (1996) Biochim. Biophys. Acta , vol.1293 , pp. 83-89
    • Yoshimoto, M.1    Ushiyama, Y.2    Sakai, M.3    Tamaki, S.4    Hara, H.5    Takahashi, K.6    Sawasaki, Y.7    Hanada, K.8
  • 15
    • 0141568946 scopus 로고    scopus 로고
    • Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2
    • Finckh, U., van Hadeln, K., Muller-Thomsen, T., Alberici, A., Binetti, G., Hock, C., Nitsch, R.M., Stoppe, G., Reiss, J. and Gal, A. (2003) Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. Neurogenetics, 4, 213-217.
    • (2003) Neurogenetics , vol.4 , pp. 213-217
    • Finckh, U.1    van Hadeln, K.2    Muller-Thomsen, T.3    Alberici, A.4    Binetti, G.5    Hock, C.6    Nitsch, R.M.7    Stoppe, G.8    Reiss, J.9    Gal, A.10
  • 17
    • 0029062606 scopus 로고
    • Computer programs for multilocus haplotyping of general pedigrees
    • Weeks D.E., Sobel E., O'Connell J.R. and Lange K. (1995) Computer programs for multilocus haplotyping of general pedigrees. Am. J. Hum. Genet., 56, 1506-1507.
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 1506-1507
    • Weeks, D.E.1    Sobel, E.2    O'Connell, J.R.3    Lange, K.4
  • 18
    • 0029945706 scopus 로고    scopus 로고
    • Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker-sharing statistics
    • Sobel, E. and Lange, K. (1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am. J. Hum. Genet., 58, 1323-1337.
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 1323-1337
    • Sobel, E.1    Lange, K.2
  • 19
    • 0000951097 scopus 로고
    • The evolutionary dynamics of complex polymorphisms
    • Lewontin, R.C. and Kojima, K. (1960) The evolutionary dynamics of complex polymorphisms. Evolution, 14, 450-472.
    • (1960) Evolution , vol.14 , pp. 450-472
    • Lewontin, R.C.1    Kojima, K.2
  • 20
    • 0031966959 scopus 로고    scopus 로고
    • Multipoint quantitative-trait linkage analysis in general pedigrees
    • Almasy, L. and Blangero, J. (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet., 62, 1198-1211.
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 1198-1211
    • Almasy, L.1    Blangero, J.2
  • 21
    • 0019920786 scopus 로고
    • Extensions to multivariate normal models for pedigree analysis
    • Hopper, J.L. and Mathews, J.D. (1982) Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet., 46, 373-383.
    • (1982) Ann. Hum. Genet. , vol.46 , pp. 373-383
    • Hopper, J.L.1    Mathews, J.D.2
  • 22
    • 0034017850 scopus 로고    scopus 로고
    • GOLD - Graphical overview of linkage disequilibrium
    • Abecasis, G.R. and Cookson, W.O. (2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics, 16, 182-183.
    • (2000) Bioinformatics , vol.16 , pp. 182-183
    • Abecasis, G.R.1    Cookson, W.O.2
  • 23
    • 0028909113 scopus 로고
    • Monte, Carlo tests for associations between disease and alleles at highly polymorphic loci
    • Sham, P.C. and Curtis, D. (1995) Monte, Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet., 59, 97-105.
    • (1995) Ann. Hum. Genet. , vol.59 , pp. 97-105
    • Sham, P.C.1    Curtis, D.2
  • 28
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi, T., Younkin, L.H., Saido, T.C., Shoji, M., Hsiao, Ashe, K. and Younkin, S.G. (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci., 21, 372-381.
    • (2001) J. Neurosci. , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Hsiao Ashe, K.5    Younkin, S.G.6
  • 29
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S. and Hirschhorn, J.N. (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet., 33, 177-182.
    • (2003) Nat. Genet. , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 31
    • 0344668728 scopus 로고    scopus 로고
    • Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    • Ertekin-Taner, N., Ronald, J., Asahara, H., Younkin, L., Hella, M., Jain, S., Gnida, E., Younkin, S., Fadale, D., Ohyagi, Y. et al. (2003) Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum. Mol. Genet., 12, 3133-3143.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 3133-3143
    • Ertekin-Taner, N.1    Ronald, J.2    Asahara, H.3    Younkin, L.4    Hella, M.5    Jain, S.6    Gnida, E.7    Younkin, S.8    Fadale, D.9    Ohyagi, Y.10
  • 32
    • 1842765688 scopus 로고    scopus 로고
    • Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer's disease
    • Ertekin-Taner, N., Allen, M., Fadale, D., Scanlin, L., Younkin, L., Petersen, R.C., Graff-Radford, N. and Younkin, S.G. (2004) Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer's disease. Hum. Mutat., 23, 334-342.
    • (2004) Hum. Mutat. , vol.23 , pp. 334-342
    • Ertekin-Taner, N.1    Allen, M.2    Fadale, D.3    Scanlin, L.4    Younkin, L.5    Petersen, R.C.6    Graff-Radford, N.7    Younkin, S.G.8
  • 33
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E.M. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 34
    • 0032903821 scopus 로고    scopus 로고
    • Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms
    • Howell, W.M., Jobs, M., Gyllensten, U. and Brookes, A.J. (1999) Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms. Nat. Biotechnol., 17, 87-88.
    • (1999) Nat. Biotechnol. , vol.17 , pp. 87-88
    • Howell, W.M.1    Jobs, M.2    Gyllensten, U.3    Brookes, A.J.4
  • 35
    • 0035147075 scopus 로고    scopus 로고
    • Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): Design criteria and assay validation
    • Prince, J.A., Feuk, L., Howell, W.M., Jobs, M., Emahazion, T., Blennow, K. and Brookes, A.J. (2001) Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): design criteria and assay validation. Genome Res., 11, 152-162.
    • (2001) Genome Res. , vol.11 , pp. 152-162
    • Prince, J.A.1    Feuk, L.2    Howell, W.M.3    Jobs, M.4    Emahazion, T.5    Blennow, K.6    Brookes, A.J.7
  • 36
    • 0003555521 scopus 로고    scopus 로고
    • Population Genetics Laboratory Department of Genetics Southwest Foundation for Biomedical Research San Antonio, TX
    • Dyke, B. and Mamelka, P. (1996) PEDSYS, A Pedigree Data Management System, version 2.0. Population Genetics Laboratory Department of Genetics Southwest Foundation for Biomedical Research, San Antonio, TX.
    • (1996) PEDSYS, A Pedigree Data Management System, Version 2.0
    • Dyke, B.1    Mamelka, P.2
  • 37
    • 0029130796 scopus 로고
    • Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
    • Excoffier, L. and Slatkin, M. (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol., 12, 921-927.
    • (1995) Mol. Biol. Evol. , vol.12 , pp. 921-927
    • Excoffier, L.1    Slatkin, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.