-
1
-
-
0034703979
-
Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
Ertekin-Taner, N., Graff-Radford, N., Younkin, L.H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M. and Younkin, S.G. (2000) Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science, 290, 2303-2304.
-
(2000)
Science
, vol.290
, pp. 2303-2304
-
-
Ertekin-Taner, N.1
Graff-Radford, N.2
Younkin, L.H.3
Eckman, C.4
Baker, M.5
Adamson, J.6
Ronald, J.7
Blangero, J.8
Hutton, M.9
Younkin, S.G.10
-
2
-
-
0034704197
-
Susceptibility locus for Alzheimer's disease on chromosome 10
-
Myers, A., Holmans, P., Marshall, H., Kwon, J., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVrieze, F.W., Crook, R. et al. (2000) Susceptibility locus for Alzheimer's disease on chromosome 10. Science, 290, 2304-2305.
-
(2000)
Science
, vol.290
, pp. 2304-2305
-
-
Myers, A.1
Holmans, P.2
Marshall, H.3
Kwon, J.4
Meyer, D.5
Ramic, D.6
Shears, S.7
Booth, J.8
DeVrieze, F.W.9
Crook, R.10
-
3
-
-
18544410708
-
The plasmin system is induced by and degrades amyloid-beta aggregates
-
Tucker, H.M., Kihiko, M., Caldwell, J.N., Wright, S., Kawarabayashi, T., Price, D., Walker, D., Scheff, S., McGillis, J.P., Rydel, R.E. et al. (2000) The plasmin system is induced by and degrades amyloid-beta aggregates. J. Neurosci., 20, 3937-3946.
-
(2000)
J. Neurosci.
, vol.20
, pp. 3937-3946
-
-
Tucker, H.M.1
Kihiko, M.2
Caldwell, J.N.3
Wright, S.4
Kawarabayashi, T.5
Price, D.6
Walker, D.7
Scheff, S.8
McGillis, J.P.9
Rydel, R.E.10
-
4
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner, G.G. and Wong, C.W. (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun., 122, 1131-1135.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
5
-
-
0028915895
-
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
-
Gravina, S.A., Ho, L., Eckman, C.B., Long, K.E., Otvos, L., Younkin, L.H., Suzuki, N. and Younkin, S.G. (1995) Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J. Biol. Chem., 270, 7013-7016.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
Long, K.E.4
Otvos, L.5
Younkin, L.H.6
Suzuki, N.7
Younkin, S.G.8
-
6
-
-
0026745610
-
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
-
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A.Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I. and Selkoe, D.J. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature, 360, 672-674.
-
(1992)
Nature
, vol.360
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
McConlogue, L.4
Hung, A.Y.5
Seubert, P.6
Vigo-Pelfrey, C.7
Lieberburg, I.8
Selkoe, D.J.9
-
7
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki, N., Cheung, T.T., Cai, X.D., Odaka, A., Otvos, L., Jr, Eckman, C., Golde, T.E. and Younkin, S.G. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science, 264, 1336-1340.
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
Odaka, A.4
Otvos Jr., L.5
Eckman, C.6
Golde, T.E.7
Younkin, S.G.8
-
8
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt, D.R., Thinakaran, G., Eckman, C.B., Lee, M.K., Davenport, F., Ratovitsky, T., Prada, C.M., Kim, G., Seekins, S., Yager, D. et al. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron, 17, 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
-
9
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin1
-
Duff, K., Eckman, C., Zehr, C., Yu, X, Prada, C.M., Perez-tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D. et al. (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin1. Nature, 383, 710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
-
10
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. and Cole, G. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science, 274, 99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
11
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T.D., Hardy, J., Hutton, M., Kukull, W. et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med., 2, 864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
-
12
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K, Lee, M., Seubert, P., Davis, A. et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med., 3, 67-72.
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
-
13
-
-
0028181436
-
Solution structure of the kringle domain from urokinase-type plasminogen activator
-
Li, X., Bokman, A.M., Llinas, M., Smith, R.A. and Dobson, C.M. (1994) Solution structure of the kringle domain from urokinase-type plasminogen activator. J. Mol. Biol., 235, 1548-1559.
-
(1994)
J. Mol. Biol.
, vol.235
, pp. 1548-1559
-
-
Li, X.1
Bokman, A.M.2
Llinas, M.3
Smith, R.A.4
Dobson, C.M.5
-
14
-
-
0029969280
-
Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure
-
Yoshimoto, M., Ushiyama, Y., Sakai, M., Tamaki, S., Hara, H., Takahashi, K., Sawasaki, Y. and Hanada, K. (1996) Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure. Biochim. Biophys. Acta, 1293, 83-89.
-
(1996)
Biochim. Biophys. Acta
, vol.1293
, pp. 83-89
-
-
Yoshimoto, M.1
Ushiyama, Y.2
Sakai, M.3
Tamaki, S.4
Hara, H.5
Takahashi, K.6
Sawasaki, Y.7
Hanada, K.8
-
15
-
-
0141568946
-
Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2
-
Finckh, U., van Hadeln, K., Muller-Thomsen, T., Alberici, A., Binetti, G., Hock, C., Nitsch, R.M., Stoppe, G., Reiss, J. and Gal, A. (2003) Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. Neurogenetics, 4, 213-217.
-
(2003)
Neurogenetics
, vol.4
, pp. 213-217
-
-
Finckh, U.1
van Hadeln, K.2
Muller-Thomsen, T.3
Alberici, A.4
Binetti, G.5
Hock, C.6
Nitsch, R.M.7
Stoppe, G.8
Reiss, J.9
Gal, A.10
-
16
-
-
0028295979
-
Physiological consequences of loss of plasminogen activator gene function in mice
-
Carmeliet, P., Schoonjans, L., Kieckens, L., Ream, B., Degen, J., Bronson, R., De Vos, R., van den Oord, J.J., Collen, D. and Mulligan, R.C. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature, 368, 419-424.
-
(1994)
Nature
, vol.368
, pp. 419-424
-
-
Carmeliet, P.1
Schoonjans, L.2
Kieckens, L.3
Ream, B.4
Degen, J.5
Bronson, R.6
De Vos, R.7
van den Oord, J.J.8
Collen, D.9
Mulligan, R.C.10
-
17
-
-
0029062606
-
Computer programs for multilocus haplotyping of general pedigrees
-
Weeks D.E., Sobel E., O'Connell J.R. and Lange K. (1995) Computer programs for multilocus haplotyping of general pedigrees. Am. J. Hum. Genet., 56, 1506-1507.
-
(1995)
Am. J. Hum. Genet.
, vol.56
, pp. 1506-1507
-
-
Weeks, D.E.1
Sobel, E.2
O'Connell, J.R.3
Lange, K.4
-
18
-
-
0029945706
-
Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker-sharing statistics
-
Sobel, E. and Lange, K. (1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am. J. Hum. Genet., 58, 1323-1337.
-
(1996)
Am. J. Hum. Genet.
, vol.58
, pp. 1323-1337
-
-
Sobel, E.1
Lange, K.2
-
19
-
-
0000951097
-
The evolutionary dynamics of complex polymorphisms
-
Lewontin, R.C. and Kojima, K. (1960) The evolutionary dynamics of complex polymorphisms. Evolution, 14, 450-472.
-
(1960)
Evolution
, vol.14
, pp. 450-472
-
-
Lewontin, R.C.1
Kojima, K.2
-
20
-
-
0031966959
-
Multipoint quantitative-trait linkage analysis in general pedigrees
-
Almasy, L. and Blangero, J. (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet., 62, 1198-1211.
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 1198-1211
-
-
Almasy, L.1
Blangero, J.2
-
21
-
-
0019920786
-
Extensions to multivariate normal models for pedigree analysis
-
Hopper, J.L. and Mathews, J.D. (1982) Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet., 46, 373-383.
-
(1982)
Ann. Hum. Genet.
, vol.46
, pp. 373-383
-
-
Hopper, J.L.1
Mathews, J.D.2
-
22
-
-
0034017850
-
GOLD - Graphical overview of linkage disequilibrium
-
Abecasis, G.R. and Cookson, W.O. (2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics, 16, 182-183.
-
(2000)
Bioinformatics
, vol.16
, pp. 182-183
-
-
Abecasis, G.R.1
Cookson, W.O.2
-
23
-
-
0028909113
-
Monte, Carlo tests for associations between disease and alleles at highly polymorphic loci
-
Sham, P.C. and Curtis, D. (1995) Monte, Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet., 59, 97-105.
-
(1995)
Ann. Hum. Genet.
, vol.59
, pp. 97-105
-
-
Sham, P.C.1
Curtis, D.2
-
24
-
-
0035947207
-
Metabolic regulation of brain Abeta by neprilysin
-
Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N.P., Gerard, C., Hama, E., Lee, H.J. and Saido, T.C. (2001) Metabolic regulation of brain Abeta by neprilysin. Science, 292 1550-1552.
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.P.6
Gerard, C.7
Hama, E.8
Lee, H.J.9
Saido, T.C.10
-
25
-
-
0035941029
-
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
-
Patil, N., Berno, A.J., Hinds, D.A., Barrett, W.A., Doshi, J.M., Hacker, C.R., Kautzer, C.R., Lee, D.H., Marjoribanks, C., McDonough, D.P. et al. (2001) Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294, 1719-1723.
-
(2001)
Science
, vol.294
, pp. 1719-1723
-
-
Patil, N.1
Berno, A.J.2
Hinds, D.A.3
Barrett, W.A.4
Doshi, J.M.5
Hacker, C.R.6
Kautzer, C.R.7
Lee, D.H.8
Marjoribanks, C.9
McDonough, D.P.10
-
26
-
-
0034791035
-
High-resolution haplotype structure in the human genome
-
Daly, M.J., Rioux, J.D., Schaffner, S.F., Hudson, T.J. and Lander, E.S. (2001) High-resolution haplotype structure in the human genome. Nat. Genet., 29, 229-232.
-
(2001)
Nat. Genet.
, vol.29
, pp. 229-232
-
-
Daly, M.J.1
Rioux, J.D.2
Schaffner, S.F.3
Hudson, T.J.4
Lander, E.S.5
-
27
-
-
18444369013
-
The structure of haplotype blocks in the human genome
-
Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M. et al. (2002) The structure of haplotype blocks in the human genome. Science, 296, 2225-2229.
-
(2002)
Science
, vol.296
, pp. 2225-2229
-
-
Gabriel, S.B.1
Schaffner, S.F.2
Nguyen, H.3
Moore, J.M.4
Roy, J.5
Blumenstiel, B.6
Higgins, J.7
DeFelice, M.8
Lochner, A.9
Faggart, M.10
-
28
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi, T., Younkin, L.H., Saido, T.C., Shoji, M., Hsiao, Ashe, K. and Younkin, S.G. (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci., 21, 372-381.
-
(2001)
J. Neurosci.
, vol.21
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
Shoji, M.4
Hsiao Ashe, K.5
Younkin, S.G.6
-
29
-
-
0037312921
-
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
-
Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S. and Hirschhorn, J.N. (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet., 33, 177-182.
-
(2003)
Nat. Genet.
, vol.33
, pp. 177-182
-
-
Lohmueller, K.E.1
Pearce, C.L.2
Pike, M.3
Lander, E.S.4
Hirschhorn, J.N.5
-
30
-
-
0346102515
-
Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD
-
Myers, A.J., Marshall, H., Holmans, P., Compton, D., Crook, R.J., Mander, A.P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L. et al. (2004) Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. Am. J. Med. Genet., 124B, 29-37.
-
(2004)
Am. J. Med. Genet.
, vol.124 B
, pp. 29-37
-
-
Myers, A.J.1
Marshall, H.2
Holmans, P.3
Compton, D.4
Crook, R.J.5
Mander, A.P.6
Nowotny, P.7
Smemo, S.8
Dunstan, M.9
Jehu, L.10
-
31
-
-
0344668728
-
Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
Ertekin-Taner, N., Ronald, J., Asahara, H., Younkin, L., Hella, M., Jain, S., Gnida, E., Younkin, S., Fadale, D., Ohyagi, Y. et al. (2003) Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum. Mol. Genet., 12, 3133-3143.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 3133-3143
-
-
Ertekin-Taner, N.1
Ronald, J.2
Asahara, H.3
Younkin, L.4
Hella, M.5
Jain, S.6
Gnida, E.7
Younkin, S.8
Fadale, D.9
Ohyagi, Y.10
-
32
-
-
1842765688
-
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer's disease
-
Ertekin-Taner, N., Allen, M., Fadale, D., Scanlin, L., Younkin, L., Petersen, R.C., Graff-Radford, N. and Younkin, S.G. (2004) Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer's disease. Hum. Mutat., 23, 334-342.
-
(2004)
Hum. Mutat.
, vol.23
, pp. 334-342
-
-
Ertekin-Taner, N.1
Allen, M.2
Fadale, D.3
Scanlin, L.4
Younkin, L.5
Petersen, R.C.6
Graff-Radford, N.7
Younkin, S.G.8
-
33
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E.M. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
34
-
-
0032903821
-
Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms
-
Howell, W.M., Jobs, M., Gyllensten, U. and Brookes, A.J. (1999) Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms. Nat. Biotechnol., 17, 87-88.
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 87-88
-
-
Howell, W.M.1
Jobs, M.2
Gyllensten, U.3
Brookes, A.J.4
-
35
-
-
0035147075
-
Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): Design criteria and assay validation
-
Prince, J.A., Feuk, L., Howell, W.M., Jobs, M., Emahazion, T., Blennow, K. and Brookes, A.J. (2001) Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): design criteria and assay validation. Genome Res., 11, 152-162.
-
(2001)
Genome Res.
, vol.11
, pp. 152-162
-
-
Prince, J.A.1
Feuk, L.2
Howell, W.M.3
Jobs, M.4
Emahazion, T.5
Blennow, K.6
Brookes, A.J.7
-
36
-
-
0003555521
-
-
Population Genetics Laboratory Department of Genetics Southwest Foundation for Biomedical Research San Antonio, TX
-
Dyke, B. and Mamelka, P. (1996) PEDSYS, A Pedigree Data Management System, version 2.0. Population Genetics Laboratory Department of Genetics Southwest Foundation for Biomedical Research, San Antonio, TX.
-
(1996)
PEDSYS, A Pedigree Data Management System, Version 2.0
-
-
Dyke, B.1
Mamelka, P.2
-
37
-
-
0029130796
-
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
-
Excoffier, L. and Slatkin, M. (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol., 12, 921-927.
-
(1995)
Mol. Biol. Evol.
, vol.12
, pp. 921-927
-
-
Excoffier, L.1
Slatkin, M.2
|