메뉴 건너뛰기




Volumn 11, Issue 9, 2006, Pages 1018-1024

Novel therapeutic developments other than EGFR and VEGF inhibition in colorectal cancer

Author keywords

Colorectal cancer; NB1011; OSI 7904L; Pemetrexed

Indexed keywords

6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; ADENOSINE A3 RECEPTOR AGONIST; AGO 41699; ANTINEOPLASTIC AGENT; CAPECITABINE; CYCLOSPORIN; DNA TOPOISOMERASE INHIBITOR; EDOTECARIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FLUOROURACIL; GYRASE INHIBITOR; IMIDACRINE; INDISULAM; IRINOTECAN; ISPINESIB; NB 1011; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OBLIMERSEN; OSI 7904 L; OXALIPLATIN; PANITUMUMAB; PEMETREXED; POLY(ADENOSINE DIPHOSPHATE RIBOSE); TEMOZOLOMIDE; THYMECTACIN; THYMIDYLATE SYNTHASE INHIBITOR; UFT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR;

EID: 33749854191     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.11-9-1018     Document Type: Article
Times cited : (9)

References (95)
  • 1
    • 27744457201 scopus 로고    scopus 로고
    • Chemotherapy for metastatic colorectal cancer
    • Rosales J, Leong LA. Chemotherapy for metastatic colorectal cancer. J Natl Compr Canc Netw 2005;3:525-529.
    • (2005) J Natl Compr Canc Netw , vol.3 , pp. 525-529
    • Rosales, J.1    Leong, L.A.2
  • 2
    • 22844443043 scopus 로고    scopus 로고
    • Systemic therapy for metastatic colorectal cancer: Current options, current evidence
    • Kelly H, Goldberg RM. Systemic therapy for metastatic colorectal cancer: current options, current evidence. J Clin Oncol 2005;23:4553-4560.
    • (2005) J Clin Oncol , vol.23 , pp. 4553-4560
    • Kelly, H.1    Goldberg, R.M.2
  • 4
    • 18444372918 scopus 로고    scopus 로고
    • Indications and effect on survival of standard chemotherapy in advanced colorectal cancer
    • Kallinowski B. Indications and effect on survival of standard chemotherapy in advanced colorectal cancer. Recent Results Cancer Res 2005;165:245-249.
    • (2005) Recent Results Cancer Res , vol.165 , pp. 245-249
    • Kallinowski, B.1
  • 5
    • 19544365274 scopus 로고    scopus 로고
    • Benefit-risk assessment of irinotecan in advanced colorectal cancer
    • Glimelius B. Benefit-risk assessment of irinotecan in advanced colorectal cancer. Drug Saf 2005;28:417-433.
    • (2005) Drug Saf , vol.28 , pp. 417-433
    • Glimelius, B.1
  • 6
    • 17144367674 scopus 로고    scopus 로고
    • The use of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer
    • Poston GJ. The use of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer. Eur J Surg Oncol 2005;31:325-330.
    • (2005) Eur J Surg Oncol , vol.31 , pp. 325-330
    • Poston, G.J.1
  • 7
    • 17644382288 scopus 로고    scopus 로고
    • Critical evaluation of current treatments in metastatic colorectal cancer
    • Venook A. Critical evaluation of current treatments in metastatic colorectal cancer. The Oncologist 2005;10:250-261.
    • (2005) The Oncologist , vol.10 , pp. 250-261
    • Venook, A.1
  • 8
    • 11344282033 scopus 로고    scopus 로고
    • Perspectives in the treatment of colorectal cancer
    • Ozer H, Diasio RB. Perspectives in the treatment of colorectal cancer. Semin Oncol 2004;31(6 suppl 15):14-18.
    • (2004) Semin Oncol , vol.31 , Issue.6 SUPPL. 15 , pp. 14-18
    • Ozer, H.1    Diasio, R.B.2
  • 9
    • 22144478699 scopus 로고    scopus 로고
    • Current therapies for advanced colorectal cancer
    • (Williston Park)
    • Aggarwal S, Chu E. Current therapies for advanced colorectal cancer. Oncology (Williston Park) 2005;19:589-595.
    • (2005) Oncology , vol.19 , pp. 589-595
    • Aggarwal, S.1    Chu, E.2
  • 10
    • 2442715094 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1- oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice
    • Desjardins J, Emerson DL, Colagiovanni DB et al. Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl] amino-1-oxo-2-isoindolynl]-glutaric acid] in mice. J Pharmacol Exp Ther 2004;309:894-902.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 894-902
    • Desjardins, J.1    Emerson, D.L.2    Colagiovanni, D.B.3
  • 11
    • 23044489791 scopus 로고    scopus 로고
    • Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors
    • Beutel G, Glen H, Schoffski P et al. Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors. Clin Cancer Res 2005;11:5487-5495.
    • (2005) Clin Cancer Res , vol.11 , pp. 5487-5495
    • Beutel, G.1    Glen, H.2    Schoffski, P.3
  • 12
    • 33749851061 scopus 로고    scopus 로고
    • Phase II pharmacokinetic (PK) and pharmacodynamic (PD) study of OSI-7904L in previously untreated patients (pts) with advanced gastric or gastroesophageal junction cancer (G/GEJC)
    • Abstract 4042
    • Falk SJ, Anthoney A, Eatock M et al. Phase II pharmacokinetic (PK) and pharmacodynamic (PD) study of OSI-7904L in previously untreated patients (pts) with advanced gastric or gastroesophageal junction cancer (G/GEJC). 2005 ASCO Annual Meeting. Abstract 4042.
    • 2005 ASCO Annual Meeting
    • Falk, S.J.1    Anthoney, A.2    Eatock, M.3
  • 13
    • 0034655141 scopus 로고    scopus 로고
    • Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: Results from a phase II study
    • John W, Picus J, Blanke CD et al. Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: results from a phase II study. Cancer 2000;88:1807-1813.
    • (2000) Cancer , vol.88 , pp. 1807-1813
    • John, W.1    Picus, J.2    Blanke, C.D.3
  • 14
    • 0032693973 scopus 로고    scopus 로고
    • Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: An NCIC Clinical Trials Group study
    • Cripps C, Burnell M, Jolivet J et al. Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: an NCIC Clinical Trials Group study. Ann Oncol 1999;10:1175-1179.
    • (1999) Ann Oncol , vol.10 , pp. 1175-1179
    • Cripps, C.1    Burnell, M.2    Jolivet, J.3
  • 15
    • 13744250037 scopus 로고    scopus 로고
    • Pemetrexed in advanced colorectal cancer
    • (Williston Park)
    • Louvet C, de Gramont A. Pemetrexed in advanced colorectal cancer. Oncology (Williston Park) 2004;18(13 suppl 8):56-62.
    • (2004) Oncology , vol.18 , Issue.13 SUPPL. 8 , pp. 56-62
    • Louvet, C.1    De Gramont, A.2
  • 16
    • 16544385662 scopus 로고    scopus 로고
    • The role of pemetrexed in the treatment of gastrointestinal malignancy
    • Hochster HS. The role of pemetrexed in the treatment of gastrointestinal malignancy. Clin Colorectal Cancer 2004;4:190-195.
    • (2004) Clin Colorectal Cancer , vol.4 , pp. 190-195
    • Hochster, H.S.1
  • 17
    • 0036266619 scopus 로고    scopus 로고
    • Pemetrexed in patients with gastrointestinal carcinoma
    • de Gramont A, Kindler HL. Pemetrexed in patients with gastrointestinal carcinoma. Semin Oncol 2002;29(17 suppl 5):42-49.
    • (2002) Semin Oncol , vol.29 , Issue.17 SUPPL. 5 , pp. 42-49
    • De Gramont, A.1    Kindler, H.L.2
  • 18
    • 0034861227 scopus 로고    scopus 로고
    • Pemetrexed disodium: A novel antifolate clinically active against multiple solid tumors
    • Hanauske AR, Chen V, Paoletti P et al. Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. The Oncologist 2001;6:363-373.
    • (2001) The Oncologist , vol.6 , pp. 363-373
    • Hanauske, A.R.1    Chen, V.2    Paoletti, P.3
  • 19
    • 32944481077 scopus 로고    scopus 로고
    • Pemetrexed/oxaliplatin for first-line treatment of patients with advanced colorectal cancer: A phase II trial of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program
    • Atkins JN, Jacobs SA, Wieand HS et al. Pemetrexed/oxaliplatin for first-line treatment of patients with advanced colorectal cancer: a phase II trial of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program. Clin Colorectal Cancer 2005;5:181-187.
    • (2005) Clin Colorectal Cancer , vol.5 , pp. 181-187
    • Atkins, J.N.1    Jacobs, S.A.2    Wieand, H.S.3
  • 20
    • 0012905181 scopus 로고    scopus 로고
    • Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction
    • Neuteboom ST, Karjian PL, Boyer CR et al. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. Mol Cancer Ther 2002;1:377-384.
    • (2002) Mol Cancer Ther , vol.1 , pp. 377-384
    • Neuteboom, S.T.1    Karjian, P.L.2    Boyer, C.R.3
  • 21
    • 0036178440 scopus 로고    scopus 로고
    • Nucleoside transport inhibitors, dipyridamole and p- nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011
    • Boyer CR, Karjian PL, Wahl GM et al. Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. Anticancer Drugs 2002;13:29-36.
    • (2002) Anticancer Drugs , vol.13 , pp. 29-36
    • Boyer, C.R.1    Karjian, P.L.2    Wahl, G.M.3
  • 22
    • 0035863169 scopus 로고    scopus 로고
    • Enzyme-catalyzed therapeutic agent (ECTA) design: Activation of the antitumor ECTA compound NB1011 by thymidylate synthase
    • Lackey DB, Groziak MP, Sergeeva M et al. Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase. Biochem Pharmacol 2001;61:179-189.
    • (2001) Biochem Pharmacol , vol.61 , pp. 179-189
    • Lackey, D.B.1    Groziak, M.P.2    Sergeeva, M.3
  • 23
    • 33749855527 scopus 로고    scopus 로고
    • Enzyme catalyzed therapeutic activation of NB1011 (N) selectively targets thymidylate synthase (TS)-overexpressing tumor cells: Phase I results
    • [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Pegram M, Yeon CH, Ku N et al. Enzyme catalyzed therapeutic activation of NB1011 (N) selectively targets thymidylate synthase (TS)-overexpressing tumor cells: phase I results. J Clin Oncol 2004;22(suppl):3144. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. , pp. 3144
    • Pegram, M.1    Yeon, C.H.2    Ku, N.3
  • 24
    • 0032791202 scopus 로고    scopus 로고
    • In vitro activation of irinotecan to SN-38 by human liver and intestine
    • Ahmed F, Vyas V, Cornfield A et al. In vitro activation of irinotecan to SN-38 by human liver and intestine. Anticancer Res 1999;19:2067-2071.
    • (1999) Anticancer Res , vol.19 , pp. 2067-2071
    • Ahmed, F.1    Vyas, V.2    Cornfield, A.3
  • 25
    • 16544370124 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: From intravenous to oral administration
    • Kuppens IE, Beijnen J, Schellens JH. Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration. Clin Colorectal Cancer 2004;4:163-180.
    • (2004) Clin Colorectal Cancer , vol.4 , pp. 163-180
    • Kuppens, I.E.1    Beijnen, J.2    Schellens, J.H.3
  • 26
    • 12444285730 scopus 로고    scopus 로고
    • Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours
    • Schoemaker NE, Kuppens IE, Huinink WW et al. Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours. Cancer Chemother Pharmacol 2005;55:263-270.
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 263-270
    • Schoemaker, N.E.1    Kuppens, I.E.2    Huinink, W.W.3
  • 27
    • 20044391814 scopus 로고    scopus 로고
    • Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semi-solid matrix capsules in patients with solid tumors
    • Soepenberg O, Dumez H, Verweij J et al. Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semi-solid matrix capsules in patients with solid tumors. Clin Cancer Res 2005;11:1504-1511.
    • (2005) Clin Cancer Res , vol.11 , pp. 1504-1511
    • Soepenberg, O.1    Dumez, H.2    Verweij, J.3
  • 28
    • 20044396542 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of oral irinotecan given once daily for 5 days every 3 weeks in combination with capecitabine in patients with solid tumors
    • Soepenberg O, Dumez H, Verweij J et al. Phase I and pharmacokinetic study of oral irinotecan given once daily for 5 days every 3 weeks in combination with capecitabine in patients with solid tumors. J Clin Oncol 2005;23:889-898.
    • (2005) J Clin Oncol , vol.23 , pp. 889-898
    • Soepenberg, O.1    Dumez, H.2    Verweij, J.3
  • 29
    • 20144388242 scopus 로고    scopus 로고
    • Preclinical safety, pharmacokinetics and antitumor efficacy profile of liposome-entrapped SN-38 formulation
    • Pal A, Khan S, Wang YF et al. Preclinical safety, pharmacokinetics and antitumor efficacy profile of liposome-entrapped SN-38 formulation. Anticancer Res 2005;25:331-341.
    • (2005) Anticancer Res , vol.25 , pp. 331-341
    • Pal, A.1    Khan, S.2    Wang, Y.F.3
  • 30
    • 4644310318 scopus 로고    scopus 로고
    • Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice
    • Lei S, Chien PY, Sheikh S et al. Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice. Anticancer Drugs 2004;15:773-778.
    • (2004) Anticancer Drugs , vol.15 , pp. 773-778
    • Lei, S.1    Chien, P.Y.2    Sheikh, S.3
  • 31
    • 0037014697 scopus 로고    scopus 로고
    • A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs
    • Liu X, Lynn BC, Zhang J et al. A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs. J Am Chem Soc 2002;124:7650-7651.
    • (2002) J Am Chem Soc , vol.124 , pp. 7650-7651
    • Liu, X.1    Lynn, B.C.2    Zhang, J.3
  • 32
    • 0034231594 scopus 로고    scopus 로고
    • Effective prodrug liposome and conversion to active metabolite
    • Sadzuka Y. Effective prodrug liposome and conversion to active metabolite. Curr Drug Metab 2000;1:31-48.
    • (2000) Curr Drug Metab , vol.1 , pp. 31-48
    • Sadzuka, Y.1
  • 33
    • 0033065077 scopus 로고    scopus 로고
    • Effective irinotecan (CPT-11)-containing liposomes: Intraliposomal conversion to the active metabolite SN-38
    • Sadzuka Y, Hirotsu S, Hirota S. Effective irinotecan (CPT-11)-containing liposomes: intraliposomal conversion to the active metabolite SN-38. Jpn J Cancer Res 1999;90:226-232.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 226-232
    • Sadzuka, Y.1    Hirotsu, S.2    Hirota, S.3
  • 34
    • 0031874686 scopus 로고    scopus 로고
    • Biologically active camptothecin derivatives for incorporation into liposome bilayers and lipid emulsions
    • Lundberg BB. Biologically active camptothecin derivatives for incorporation into liposome bilayers and lipid emulsions. Anticancer Drug Des 1998;13:453-461.
    • (1998) Anticancer Drug des , vol.13 , pp. 453-461
    • Lundberg, B.B.1
  • 35
    • 21844454211 scopus 로고    scopus 로고
    • Edotecarin: A novel topoisomerase I inhibitor
    • Saif MW, Diasio RB. Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer 2005;5:27-36.
    • (2005) Clin Colorectal Cancer , vol.5 , pp. 27-36
    • Saif, M.W.1    Diasio, R.B.2
  • 36
    • 2442674419 scopus 로고    scopus 로고
    • Edotecarin
    • Denny WA. Edotecarin. IDrugs 2004;7:173-177.
    • (2004) IDrugs , vol.7 , pp. 173-177
    • Denny, W.A.1
  • 37
    • 0033199091 scopus 로고    scopus 로고
    • Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I
    • Yoshinari T, Ohkubo M, Fukasawa K et al. Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I. Cancer Res 1999;59:4271-4275.
    • (1999) Cancer Res , vol.59 , pp. 4271-4275
    • Yoshinari, T.1    Ohkubo, M.2    Fukasawa, K.3
  • 38
    • 0032855120 scopus 로고    scopus 로고
    • Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311
    • Burger AM, Jenkins TC, Double JA et al. Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311. Br J Cancer 1999;81:367-375.
    • (1999) Br J Cancer , vol.81 , pp. 367-375
    • Burger, A.M.1    Jenkins, T.C.2    Double, J.A.3
  • 39
    • 10744221722 scopus 로고    scopus 로고
    • Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats
    • Arimori K, Kuroki N, Hidaka M et al. Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats. Pharm Res 2003;20:910-917.
    • (2003) Pharm Res , vol.20 , pp. 910-917
    • Arimori, K.1    Kuroki, N.2    Hidaka, M.3
  • 40
    • 0037237435 scopus 로고    scopus 로고
    • Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity
    • Tsuboi K, Tazuma S, Ochi H et al. Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. Hepatol Res 2003;25:38-47.
    • (2003) Hepatol Res , vol.25 , pp. 38-47
    • Tsuboi, K.1    Tazuma, S.2    Ochi, H.3
  • 41
    • 16444386695 scopus 로고    scopus 로고
    • Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line
    • Echevarria-Lima J, Kyle-Cezar FP, Leite DF et al. Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line. Immunology 2005;114:468-475.
    • (2005) Immunology , vol.114 , pp. 468-475
    • Echevarria-Lima, J.1    Kyle-Cezar, F.P.2    Leite, D.F.3
  • 42
    • 27144541444 scopus 로고    scopus 로고
    • Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins
    • Sep 1; [Epub ahead of print]
    • Tian Q, Zhang J, Tan TM et al. Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins. Pharm Res 2005 Sep 1; [Epub ahead of print].
    • (2005) Pharm Res
    • Tian, Q.1    Zhang, J.2    Tan, T.M.3
  • 43
    • 84871472349 scopus 로고    scopus 로고
    • Modulation of Irinotecan (CPT-11) Toxicity and Pharmacokinetics by Cyclosporine and Phenobarbital
    • Abstract
    • Ratain MJ, Innocenti F, Vogelzang NJ et al. Modulation of Irinotecan (CPT-11) Toxicity and Pharmacokinetics by Cyclosporine and Phenobarbital. Proc Am Soc Clin Oncol 2001;19:291. Abstract.
    • (2001) Proc Am Soc Clin Oncol , vol.19 , pp. 291
    • Ratain, M.J.1    Innocenti, F.2    Vogelzang, N.J.3
  • 44
    • 10744226451 scopus 로고    scopus 로고
    • Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
    • Calabrese CR, Almassy R, Barton S et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst 2004;96:56-67.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 56-67
    • Calabrese, C.R.1    Almassy, R.2    Barton, S.3
  • 45
    • 0242588748 scopus 로고    scopus 로고
    • Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor
    • Miknyoczki SJ, Jones-Bolin S, Pritchard S et al. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther 2003;2:371-382.
    • (2003) Mol Cancer Ther , vol.2 , pp. 371-382
    • Miknyoczki, S.J.1    Jones-Bolin, S.2    Pritchard, S.3
  • 46
    • 16244377468 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
    • Vullo D, Innocenti A, Nishimori I et al. Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs? Bioorg Med Chem Lett 2005;15:963-969.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 963-969
    • Vullo, D.1    Innocenti, A.2    Nishimori, I.3
  • 47
    • 25144469687 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides
    • Sep 12; [Epub ahead of print]
    • Innocenti A, Villar R, Martinez-Merino V, et al. Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides. Bioorg Med Chem Lett 2005 Sep 12; [Epub ahead of print].
    • (2005) Bioorg Med Chem Lett
    • Innocenti, A.1    Villar, R.2    Martinez-Merino, V.3
  • 48
    • 0038778477 scopus 로고    scopus 로고
    • New analogues of the anticancer E7070: Synthesis and pharmacology
    • Laconde G, Pommery N, Depreux P et al. New analogues of the anticancer E7070: synthesis and pharmacology. J Enzyme Inhib Med Chem 2003;18:89-94.
    • (2003) J Enzyme Inhib Med Chem , vol.18 , pp. 89-94
    • Laconde, G.1    Pommery, N.2    Depreux, P.3
  • 49
    • 21044442985 scopus 로고    scopus 로고
    • Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam
    • van Kesteren C, Zandvliet AS, Karlsson MO et al. Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam. Invest New Drugs 2005;23:225-234.
    • (2005) Invest New Drugs , vol.23 , pp. 225-234
    • Van Kesteren, C.1    Zandvliet, A.S.2    Karlsson, M.O.3
  • 50
    • 33644512888 scopus 로고    scopus 로고
    • A phase II multicenter study of the cyclin-dependent kinase inhibitor indisulam in patients with progressive inoperable and/or metastatic renal cell carcinoma (RCC)
    • [Abstract, ASCO Annual Meeting Proceedings Post-Meeting Ed.]
    • Raftopoulos H, Escudier B, Renshaw G et al. A phase II multicenter study of the cyclin-dependent kinase inhibitor indisulam in patients with progressive inoperable and/or metastatic renal cell carcinoma (RCC). J Clin Oncol 2004;22(suppl):4629. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.]
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. , pp. 4629
    • Raftopoulos, H.1    Escudier, B.2    Renshaw, G.3
  • 51
    • 33749827530 scopus 로고    scopus 로고
    • A phase I study of E7070, a chloroindolyl-sulfonamide, in combination with irinotecan in gastrointestinal and thoracic carcinomas
    • Abstract 2031
    • Ryan DP, Eder J, Appleman L et al. A phase I study of E7070, a chloroindolyl-sulfonamide, in combination with irinotecan in gastrointestinal and thoracic carcinomas. 2005 ASCO Annual Meeting. Abstract 2031.
    • 2005 ASCO Annual Meeting
    • Ryan, D.P.1    Eder, J.2    Appleman, L.3
  • 52
    • 25844479168 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5
    • Aug 2; [Epub ahead of print]
    • Sunder-Plassmann N, Sarli V, Gartner M et al. Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5. Bioorg Med Chem 2005 Aug 2; [Epub ahead of print].
    • (2005) Bioorg Med Chem
    • Sunder-Plassmann, N.1    Sarli, V.2    Gartner, M.3
  • 53
    • 22244459880 scopus 로고    scopus 로고
    • Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
    • Tao W, South VJ, Zhang Y et al. Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage. Cancer Cell 2005;8:49-59.
    • (2005) Cancer Cell , vol.8 , pp. 49-59
    • Tao, W.1    South, V.J.2    Zhang, Y.3
  • 54
    • 2342563857 scopus 로고    scopus 로고
    • Antitumor activity of a kinesin inhibitor
    • Sakowicz R, Finer JT, Beraud C et al. Antitumor activity of a kinesin inhibitor. Cancer Res 2004;64:3276-3280.
    • (2004) Cancer Res , vol.64 , pp. 3276-3280
    • Sakowicz, R.1    Finer, J.T.2    Beraud, C.3
  • 55
    • 13444255917 scopus 로고    scopus 로고
    • CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model
    • Bar-Yehuda S, Madi L, Silberman D et al. CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model. Neoplasia 2005;7:85-90.
    • (2005) Neoplasia , vol.7 , pp. 85-90
    • Bar-Yehuda, S.1    Madi, L.2    Silberman, D.3
  • 56
    • 1942532883 scopus 로고    scopus 로고
    • An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B
    • Fishman P, Bar-Yehuda S, Ohana G et al. An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B. Oncogene 2004;23:2465-2471.
    • (2004) Oncogene , vol.23 , pp. 2465-2471
    • Fishman, P.1    Bar-Yehuda, S.2    Ohana, G.3
  • 57
    • 0242574653 scopus 로고    scopus 로고
    • Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101
    • Ohana G, Bar-Yehuda S, Arich A et al. Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101. Br J Cancer 2003;89:1552-1558.
    • (2003) Br J Cancer , vol.89 , pp. 1552-1558
    • Ohana, G.1    Bar-Yehuda, S.2    Arich, A.3
  • 58
    • 18744393077 scopus 로고    scopus 로고
    • Agonists to the A3 adenosine receptor induce G-CSF production via NF-kappaB activation: A new class of myeloprotective agents
    • Bar-Yehuda S, Madi L, Barak D et al. Agonists to the A3 adenosine receptor induce G-CSF production via NF-kappaB activation: a new class of myeloprotective agents. Exp Hematol 2002;30:1390-1398.
    • (2002) Exp Hematol , vol.30 , pp. 1390-1398
    • Bar-Yehuda, S.1    Madi, L.2    Barak, D.3
  • 59
    • 33749872186 scopus 로고    scopus 로고
    • CF101 enhances the apoptotic effect of chemotherapy on colon and pancreatic carcinoma cell lines: Molecular mechanisms involved
    • [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Fishman P, Yehuda SB, Stemmer SM et al. CF101 enhances the apoptotic effect of chemotherapy on colon and pancreatic carcinoma cell lines: Molecular mechanisms involved. J Clin Oncol 2004;22(suppl 14):3173. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14 , pp. 3173
    • Fishman, P.1    Yehuda, S.B.2    Stemmer, S.M.3
  • 60
    • 33749840059 scopus 로고    scopus 로고
    • A phase II, multi-center study of a new non-cytotoxic A3 adenosine receptor agonist CF101, dose-finding (randomized blinded) in patients (pts)with refractory metastatic colorectal cancer
    • [Abstract, ASCO Annual Meeting Proceedings Post-Meeting Ed.]
    • Stemmer SM, Shani A, Klein B et al. A phase II, multi-center study of a new non-cytotoxic A3 adenosine receptor agonist CF101, dose-finding (randomized blinded) in patients (pts)with refractory metastatic colorectal cancer. J Clin Oncol 2004;22(suppl 14):3153. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.]
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14 , pp. 3153
    • Stemmer, S.M.1    Shani, A.2    Klein, B.3
  • 61
    • 14144254200 scopus 로고    scopus 로고
    • Apoptosis, Bcl-2 antisense, and cancer therapy
    • (Williston Park)
    • Piro LD. Apoptosis, Bcl-2 antisense, and cancer therapy. Oncology (Williston Park) 2004;18(13 suppl 10):5-10.
    • (2004) Oncology , vol.18 , Issue.13 SUPPL. 10 , pp. 5-10
    • Piro, L.D.1
  • 62
    • 0033917834 scopus 로고    scopus 로고
    • Cellular response to a glutathione S-transferase P1-1 activated prodrug
    • Rosario LA, O'Brien ML, Henderson CJ et al. Cellular response to a glutathione S-transferase P1-1 activated prodrug. Mol Pharmacol 2000;58:167-174.
    • (2000) Mol Pharmacol , vol.58 , pp. 167-174
    • Rosario, L.A.1    O'Brien, M.L.2    Henderson, C.J.3
  • 63
    • 17144463182 scopus 로고    scopus 로고
    • Glutathione based approaches to improving cancer treatment
    • Kauvar LM, Morgan AS, Sanderson PE et al. Glutathione based approaches to improving cancer treatment. Chem Biol Interact 1998;111-112:225-238.
    • (1998) Chem Biol Interact , vol.111-112 , pp. 225-238
    • Kauvar, L.M.1    Morgan, A.S.2    Sanderson, P.E.3
  • 65
    • 2342552060 scopus 로고    scopus 로고
    • TLK 286
    • [No authors listed]
    • [No authors listed]. TLK 286. Drugs R D 2004;5(2):116-118.
    • (2004) Drugs R D , vol.5 , Issue.2 , pp. 116-118
  • 66
    • 21044441651 scopus 로고    scopus 로고
    • HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
    • Pukac L, Kanakaraj P, Humphreys R et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br J Cancer 2005;92:1430-1441.
    • (2005) Br J Cancer , vol.92 , pp. 1430-1441
    • Pukac, L.1    Kanakaraj, P.2    Humphreys, R.3
  • 67
    • 32544441947 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle cell lymphoma through generation of ROS species and Noxa activation independent of p53 status
    • Sep 15; [Epub ahead of print]
    • Perez-Galan P, Roue G, Villamor N et al. The proteasome inhibitor bortezomib induces apoptosis in mantle cell lymphoma through generation of ROS species and Noxa activation independent of p53 status. Blood 2005 Sep 15; [Epub ahead of print].
    • (2005) Blood
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3
  • 68
    • 24744456734 scopus 로고    scopus 로고
    • Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells
    • Altun M, Galardy PJ, Shringarpure R et al. Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. Cancer Res 2005;65:7896-7901.
    • (2005) Cancer Res , vol.65 , pp. 7896-7901
    • Altun, M.1    Galardy, P.J.2    Shringarpure, R.3
  • 70
    • 0346692671 scopus 로고    scopus 로고
    • Bortezomib (millennium pharmaceuticals)
    • Dou QP, Goldfarb RH. Bortezomib (millennium pharmaceuticals). IDrugs 2002;5:828-834.
    • (2002) IDrugs , vol.5 , pp. 828-834
    • Dou, Q.P.1    Goldfarb, R.H.2
  • 71
    • 23044431754 scopus 로고    scopus 로고
    • A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer
    • Mackay H, Hedley D, Major P et al. A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res 2005;11:5526-5533.
    • (2005) Clin Cancer Res , vol.11 , pp. 5526-5533
    • Mackay, H.1    Hedley, D.2    Major, P.3
  • 72
    • 67349263502 scopus 로고    scopus 로고
    • Phase II study of PS-341 (VELCADE, bortezomib) with or without irinotecan in patients (pts) with advanced gastric adenocarcinomas (AGA)
    • [Abstract 31]
    • Ocean AJ, Schnoll-Sussman F, Chen X et al. Phase II study of PS-341 (VELCADE, bortezomib) with or without irinotecan in patients (pts) with advanced gastric adenocarcinomas (AGA). 2005 Gastrointestinal Cancers Symposium. [Abstract 31].
    • 2005 Gastrointestinal Cancers Symposium
    • Ocean, A.J.1    Schnoll-Sussman, F.2    Chen, X.3
  • 73
    • 4043177145 scopus 로고    scopus 로고
    • Epothilone D (Kosan/Roche)
    • Kolman A. Epothilone D (Kosan/Roche). Curr Opin Investig Drugs 2004;5:657-667.
    • (2004) Curr Opin Investig Drugs , vol.5 , pp. 657-667
    • Kolman, A.1
  • 74
    • 0037838495 scopus 로고    scopus 로고
    • EPO906 (epothilone B): A promising novel microtubule stabilizer
    • Rothermel J, Wartmann M, Chen T et al. EPO906 (epothilone B): a promising novel microtubule stabilizer. Semin Oncol 2003;30(3 suppl 6):51-55.
    • (2003) Semin Oncol , vol.30 , Issue.3 SUPPL. 6 , pp. 51-55
    • Rothermel, J.1    Wartmann, M.2    Chen, T.3
  • 75
    • 3442898528 scopus 로고    scopus 로고
    • A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer
    • Eng C, Kindler HL, Nattam S et al. A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer. Ann Oncol 2004;15:928-932.
    • (2004) Ann Oncol , vol.15 , pp. 928-932
    • Eng, C.1    Kindler, H.L.2    Nattam, S.3
  • 76
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • Lee FY, Borzilleri R, Fairchild CR et al. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 2001;7:1429-1437.
    • (2001) Clin Cancer Res , vol.7 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 77
    • 3042701597 scopus 로고    scopus 로고
    • Epothilones: Mechanism of action and biologic activity
    • Goodin S, Kane MP, Rubin EH. Epothilones: mechanism of action and biologic activity. J Clin Oncol 2004;22:2015-2025.
    • (2004) J Clin Oncol , vol.22 , pp. 2015-2025
    • Goodin, S.1    Kane, M.P.2    Rubin, E.H.3
  • 79
    • 4344647867 scopus 로고    scopus 로고
    • Tumor selective antivascular effects of the novel antimitotic compound ABT-751: An in vivo rat regional hemodynamic study
    • Segreti JA, Polakowski JS, Koch KA et al. Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study. Cancer Chemother Pharmacol 2004;54:273-281.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 273-281
    • Segreti, J.A.1    Polakowski, J.S.2    Koch, K.A.3
  • 80
    • 85038464472 scopus 로고    scopus 로고
    • Phase 2 Study of ABT-751 in Patients with Refractory Metastatic Colorectal Carcinoma (CRC)
    • [Abstract 3537]
    • Benson B, Kindler HL, Jodrell D et al. Phase 2 Study of ABT-751 in Patients with Refractory Metastatic Colorectal Carcinoma (CRC). 2005 ASCO Annual Meeting. [Abstract 3537].
    • 2005 ASCO Annual Meeting
    • Benson, B.1    Kindler, H.L.2    Jodrell, D.3
  • 81
    • 17644386490 scopus 로고    scopus 로고
    • Development of humanized antibodies as cancer therapeutics
    • Qu Z, Griffiths GL, Wegener WA et al. Development of humanized antibodies as cancer therapeutics. Methods 2005;36:84-95.
    • (2005) Methods , vol.36 , pp. 84-95
    • Qu, Z.1    Griffiths, G.L.2    Wegener, W.A.3
  • 82
    • 12344261775 scopus 로고    scopus 로고
    • A humanized monoclonal antibody to carcinoembryonic antigen, labetuzumab, inhibits tumor growth and sensitizes human medullary thyroid cancer xenografts to dacarbazine chemotherapy
    • Stein R, Goldenberg DM. A humanized monoclonal antibody to carcinoembryonic antigen, labetuzumab, inhibits tumor growth and sensitizes human medullary thyroid cancer xenografts to dacarbazine chemotherapy. Mol Cancer Ther 2004;3:1559-1564.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1559-1564
    • Stein, R.1    Goldenberg, D.M.2
  • 83
    • 12344331324 scopus 로고    scopus 로고
    • Carcinoembryonic antigen antibody inhibits lung metastasis and augments chemotherapy in a human colonic carcinoma xenograft
    • Blumenthal RD, Osorio L, Hayes MK et al. Carcinoembryonic antigen antibody inhibits lung metastasis and augments chemotherapy in a human colonic carcinoma xenograft. Cancer Immunol Immunother 2005;54:315-327.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 315-327
    • Blumenthal, R.D.1    Osorio, L.2    Hayes, M.K.3
  • 84
    • 19644379671 scopus 로고    scopus 로고
    • A phase I trial combining high-dose 90Y-labeled humanized anti-CEA monoclonal antibody with doxorubicin and peripheral blood stem cell rescue in advanced medullary thyroid cancer
    • Sharkey RM, Hajjar G, Yeldell D et al. A phase I trial combining high-dose 90Y-labeled humanized anti-CEA monoclonal antibody with doxorubicin and peripheral blood stem cell rescue in advanced medullary thyroid cancer. J Nucl Med 2005;46:620-633.
    • (2005) J Nucl Med , vol.46 , pp. 620-633
    • Sharkey, R.M.1    Hajjar, G.2    Yeldell, D.3
  • 85
    • 33749821370 scopus 로고    scopus 로고
    • CEA Radioimmunotherapy with 131I-Labetuzumab Improves Survival Post Salvage Resection of Colorectal Cancer Metastases in the Liver
    • [Abstract 3627]
    • Liersch T, Meller J, Kulle B et al. CEA Radioimmunotherapy with 131I-Labetuzumab Improves Survival Post Salvage Resection of Colorectal Cancer Metastases in the Liver. 2005 ASCO Annual Meeting. [Abstract 3627].
    • 2005 ASCO Annual Meeting
    • Liersch, T.1    Meller, J.2    Kulle, B.3
  • 86
    • 0036923946 scopus 로고    scopus 로고
    • Technology evaluation: ALVAC-CEA/B7.1, Aventis Pasteur/Therion
    • Ertl HC. Technology evaluation: ALVAC-CEA/B7.1, Aventis Pasteur/Therion. Curr Opin Mol Ther 2002;4:601-605.
    • (2002) Curr Opin Mol Ther , vol.4 , pp. 601-605
    • Ertl, H.C.1
  • 87
    • 0034900416 scopus 로고    scopus 로고
    • The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma
    • von Mehren M, Arlen P, Gulley J et al. The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma. Clin Cancer Res 2001;7:1181-1191.
    • (2001) Clin Cancer Res , vol.7 , pp. 1181-1191
    • Von Mehren, M.1    Arlen, P.2    Gulley, J.3
  • 88
    • 0033766694 scopus 로고    scopus 로고
    • Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule
    • Horig H, Lee DS, Conkright W et al. Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule. Cancer Immunol Immunother 2000;49:504-514.
    • (2000) Cancer Immunol Immunother , vol.49 , pp. 504-514
    • Horig, H.1    Lee, D.S.2    Conkright, W.3
  • 89
    • 0034122338 scopus 로고    scopus 로고
    • Pilot study of a dual gene recombinant avipox vaccine containing both carcinoembryonic antigen (CEA) and B7.1 transgenes in patients with recurrent CEA-expressing adenocarcinomas
    • von Mehren M, Arlen P, Tsang KY et al. Pilot study of a dual gene recombinant avipox vaccine containing both carcinoembryonic antigen (CEA) and B7.1 transgenes in patients with recurrent CEA-expressing adenocarcinomas. Clin Cancer Res 2000;6:2219-2228.
    • (2000) Clin Cancer Res , vol.6 , pp. 2219-2228
    • Von Mehren, M.1    Arlen, P.2    Tsang, K.Y.3
  • 90
    • 14844309609 scopus 로고    scopus 로고
    • Immunotherapy with autologous tumor cell-BCG vaccine in patients with colon cancer: A prospective study of medical and economic benefits
    • Uyl-de Groot CA, Vermorken JB, Hanna MG Jr. et al. Immunotherapy with autologous tumor cell-BCG vaccine in patients with colon cancer: a prospective study of medical and economic benefits. Vaccine 2005;23(17-18):2379-2387.
    • (2005) Vaccine , vol.23 , Issue.17-18 , pp. 2379-2387
    • Uyl-de Groot, C.A.1    Vermorken, J.B.2    Hanna Jr., M.G.3
  • 91
    • 0036230608 scopus 로고    scopus 로고
    • Cancer vaccine-Antigenics
    • [No authors listed]
    • [No authors listed]. Cancer vaccine-Antigenics. BioDrugs 2002;16(1):72-74.
    • (2002) BioDrugs , vol.16 , Issue.1 , pp. 72-74
  • 92
    • 10744233222 scopus 로고    scopus 로고
    • Vaccination with autologous tumor derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer
    • Mazzaferro V, Coppa JC, Carrabba MG et al. Vaccination with autologous tumor derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. Clin Cancer Res 2003;9:3235-3245.
    • (2003) Clin Cancer Res , vol.9 , pp. 3235-3245
    • Mazzaferro, V.1    Coppa, J.C.2    Carrabba, M.G.3
  • 93
    • 4444369990 scopus 로고    scopus 로고
    • Technology evaluation: TroVax, Oxford BioMedica
    • Reinis M. Technology evaluation: TroVax, Oxford BioMedica. Curr Opin Mol Ther 2004;6:436-442.
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 436-442
    • Reinis, M.1
  • 94
    • 21344432170 scopus 로고    scopus 로고
    • Phase I study of escalating doses of TroVax in patients with advanced colorectal cancer (CRC)
    • [Abstract 726]
    • Valle JW, Connolly NB, Harrop R et al. Phase I study of escalating doses of TroVax in patients with advanced colorectal cancer (CRC). Proc Am Soc Clin Oncol 2003;22:181. [Abstract 726].
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 181
    • Valle, J.W.1    Connolly, N.B.2    Harrop, R.3
  • 95
    • 33746026059 scopus 로고    scopus 로고
    • An open label phase II study of modified vaccinia ankara (MVA) expressing the tumor antigen 5T4 given in conjunction with chemotherapy: Safety and immunogenicity before, during and after chemotherapy
    • [Abstract 2578]
    • Harrop R, Hawkins R, Anthoney A et al. An open label phase II study of modified vaccinia ankara (MVA) expressing the tumor antigen 5T4 given in conjunction with chemotherapy: safety and immunogenicity before, during and after chemotherapy. 2005 ASCO Annual Meeting. [Abstract 2578].
    • 2005 ASCO Annual Meeting
    • Harrop, R.1    Hawkins, R.2    Anthoney, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.