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Volumn 4, Issue 3, 2004, Pages 190-195

The role of pemetrexed in the treatment of gastrointestinal malignancy

Author keywords

5 FU; Antifolate; Combination therapy; Gemcitabine; Methotrexate; Targeted therapy; Thymidylate synthase

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; DRUG DERIVATIVE; GLUTAMIC ACID DERIVATIVE; GUANINE; PEMETREXED;

EID: 16544385662     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2004.n.019     Document Type: Review
Times cited : (5)

References (32)
  • 1
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. Advanced colorectal cancer meta-analysis project
    • Meta-analysis Group
    • Meta-analysis Group: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. Advanced colorectal cancer meta-analysis project. J Clin Oncol 1992; 10:896-903.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 2
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-analysis Group In Cancer
    • Meta-analysis Group In Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol. 1998; 16:301-308.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 3
    • 0032585232 scopus 로고    scopus 로고
    • Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D, Pyrhonen S, James RD, et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998; 352:1413-1418.
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 4
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 2000; 343:905-914.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 5
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 2000; 355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 6
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18:2938-2947.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 7
    • 0043215754 scopus 로고    scopus 로고
    • Final results of a phase III trial of 5-FU/leucovorin versus oxaliplatin versus the combination in patients with metastatic colorectal cancer following irinotecan, 5-FU, and leucovorin
    • Abstract
    • Rothenberg ML, Oza AM, Burger B, et al. Final results of a phase III trial of 5-FU/leucovorin versus oxaliplatin versus the combination in patients with metastatic colorectal cancer following irinotecan, 5-FU, and leucovorin. Proc Am Soc Clin Oncol 2003; 22:252 (Abstract #1011).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.1011 , pp. 252
    • Rothenberg, M.L.1    Oza, A.M.2    Burger, B.3
  • 8
    • 0042213493 scopus 로고    scopus 로고
    • N9741: Oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study
    • Abstract
    • Goldberg RM, Morton RF, Sargent DJ, et al. N9741: oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study. Proc Am Soc Clin Oncol 2003; 22:252 (Abstract #1009).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.1009 , pp. 252
    • Goldberg, R.M.1    Morton, R.F.2    Sargent, D.J.3
  • 9
    • 0003226922 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX versus FOLFOX followed by FOLFIRI in metastatic colorectal cancer (MCRC): Final results of a phase III study
    • Abstract
    • Tournigand C, Louvet C, Quinaux E, et al. FOLFIRI followed by FOLFOX versus FOLFOX followed by FOLFIRI in metastatic colorectal cancer (MCRC): Final results of a phase III study. Proc Am Soc Clin Oncol 2001; 20:124a (Abstract #494).
    • (2001) Proc Am Soc Clin Oncol , vol.20 , Issue.494
    • Tournigand, C.1    Louvet, C.2    Quinaux, E.3
  • 10
    • 0032693973 scopus 로고    scopus 로고
    • Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: An NCIC Clinical Trials Group study
    • Cripps C, Burnell M, Jolivet J, et al. Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: An NCIC Clinical Trials Group study. Ann Oncol 1999; 10:1175-1179.
    • (1999) Ann Oncol , vol.10 , pp. 1175-1179
    • Cripps, C.1    Burnell, M.2    Jolivet, J.3
  • 11
    • 0034655141 scopus 로고    scopus 로고
    • Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: Results from a phase II study
    • John W, Picus J, Blanke CD, et al. Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: Results from a phase II study. Cancer 2000; 88:1807-1813.
    • (2000) Cancer , vol.88 , pp. 1807-1813
    • John, W.1    Picus, J.2    Blanke, C.D.3
  • 12
    • 0003199131 scopus 로고    scopus 로고
    • A phase II trial of MTA (multiple targeted antifolate, LY231514) in patients with 5-FU and irinotecan-refractory colorectal cancer
    • Abstract
    • Paulson R, Hainsworth J, Geyer C, et al. A phase II trial of MTA (multiple targeted antifolate, LY231514) in patients with 5-FU and irinotecan-refractory colorectal cancer. Proc Am Soc Clin Oncol 1999; 18:297a (Abstract #1140).
    • (1999) Proc Am Soc Clin Oncol , vol.18 , Issue.1140
    • Paulson, R.1    Hainsworth, J.2    Geyer, C.3
  • 13
    • 0003205742 scopus 로고    scopus 로고
    • Pemetrexed/oxaliplatin (LOHP) combination: Results of a phase I study in metastatic solid tumors
    • Abstract
    • Misset JL, Gaemlin E, Campone M, et al. Pemetrexed/oxaliplatin (LOHP) combination: Results of a phase I study in metastatic solid tumors. Clin Pharmacol 2002; 21:107a (Abstract #427).
    • (2002) Clin Pharmacol , vol.21 , Issue.427
    • Misset, J.L.1    Gaemlin, E.2    Campone, M.3
  • 14
    • 85031371529 scopus 로고    scopus 로고
    • Atkins JN, Jacobs S, Wieand S, et al. Pemetrexed and oxaliplatin for first-line treatment of patients with advanced colorectal cancer: A phase II trial of the NSABP foundation research program. Proc Am Soc Clin Oncol 2003; 22:276 (Abstract #1108).
    • Atkins JN, Jacobs S, Wieand S, et al. Pemetrexed and oxaliplatin for first-line treatment of patients with advanced colorectal cancer: A phase II trial of the NSABP foundation research program. Proc Am Soc Clin Oncol 2003; 22:276 (Abstract #1108).
  • 15
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 1997; 15:2403-2413.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris 3rd, H.A.1    Moore, M.J.2    Andersen, J.3
  • 16
    • 0036467995 scopus 로고    scopus 로고
    • Prolonged infusion of gemcitabine: Clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia
    • Gandhi V, Plunkett W, Du M, et al. Prolonged infusion of gemcitabine: Clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia. J Clin Oncol 2002; 20:665-673.
    • (2002) J Clin Oncol , vol.20 , pp. 665-673
    • Gandhi, V.1    Plunkett, W.2    Du, M.3
  • 17
    • 0142121290 scopus 로고    scopus 로고
    • Randomized Phase II Comparison of Dose-Intense Gemcitabine: Thirty-minute Infusion and Fixed Dose Rate Infusion in Patients with Pancreatic Adenocarcinoma
    • Tempero M, Plunkett W, Ruiz Van Haperen V, et. al. Randomized Phase II Comparison of Dose-Intense Gemcitabine: Thirty-minute Infusion and Fixed Dose Rate Infusion in Patients with Pancreatic Adenocarcinoma. J Clin Oncol 2003; 21:3402-3408.
    • (2003) J Clin Oncol , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz Van Haperen, V.3    et., al.4
  • 18
    • 0032859301 scopus 로고    scopus 로고
    • A phase I evaluation of multitargeted antifolate (MTA, LY231514) administered every 21 days, utilizing modified continual reassessment method for dose escalation
    • Rinaldi DA, Kuhn JG, Burris HA, et al: A phase I evaluation of multitargeted antifolate (MTA, LY231514) administered every 21 days, utilizing modified continual reassessment method for dose escalation. Cancer Chemother Pharmacol 1999; 44:372-380.
    • (1999) Cancer Chemother Pharmacol , vol.44 , pp. 372-380
    • Rinaldi, D.A.1    Kuhn, J.G.2    Burris, H.A.3
  • 19
    • 0033981350 scopus 로고    scopus 로고
    • Phase II study of the multi-targeted antifolate LY231514 (Alimta, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer
    • Miller KD, Picus J, Blanke C, et al. Phase II study of the multi-targeted antifolate LY231514 (Alimta, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer. Ann Oncol 2000; 11:101-103.
    • (2000) Ann Oncol , vol.11 , pp. 101-103
    • Miller, K.D.1    Picus, J.2    Blanke, C.3
  • 20
    • 0033993714 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors
    • Adjei AA, Erlichman C, Sloan JA, et al. Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors. J Clin Oncol 2000; 18:1748-1757.
    • (2000) J Clin Oncol , vol.18 , pp. 1748-1757
    • Adjei, A.A.1    Erlichman, C.2    Sloan, J.A.3
  • 21
    • 0000539776 scopus 로고    scopus 로고
    • Clinical outcome in patients (pts) with advanced pancreatic cancer treated with pemetrexed/gemcitabine
    • Abstract
    • Kindler HL, Dugan W, Hochster H, et al. Clinical outcome in patients (pts) with advanced pancreatic cancer treated with pemetrexed/gemcitabine Proc Am Soc Clin Oncol 2002; 21:125a (Abstract #499).
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.499
    • Kindler, H.L.1    Dugan, W.2    Hochster, H.3
  • 22
    • 85031384019 scopus 로고    scopus 로고
    • Richards DA, Kindler HL, Oettle H, et al. A randomized phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas cancer. Presented as a late-breaking abstract at the 40th Annual Meeting of the American Society of Clinical Oncology, June 5-8 2004; New Orleans, LA. Abstract #4007.
    • Richards DA, Kindler HL, Oettle H, et al. A randomized phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas cancer. Presented as a late-breaking abstract at the 40th Annual Meeting of the American Society of Clinical Oncology, June 5-8 2004; New Orleans, LA. Abstract #4007.
  • 23
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, van deVelde H, Karasek P, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004; 22:1430-1438.
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    van deVelde, H.2    Karasek, P.3
  • 24
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, et al. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002; 20:3270-3275.
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3
  • 25
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Hamm J, Dancey J, et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003; 21:3296-3302.
    • (2003) J Clin Oncol , vol.21 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3
  • 26
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Bramhall SR, Rosemurgy A, Brown PD, et al. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol 2001; 19:3447-3455.
    • (2001) J Clin Oncol , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3
  • 27
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first-line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first-line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002; 87:161-167.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 28
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: A prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci G, Giuliani F, Gebbia V, et al. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 2002; 94:902-910.
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3
  • 29
    • 1542358227 scopus 로고    scopus 로고
    • A phase III trial comparing gemcitabine plus cisplatin vs. gemcitabine alone in advanced pancreatic carcinoma
    • Abstract
    • Heinemann V, Quietzsch D, Giesler F, et al. A phase III trial comparing gemcitabine plus cisplatin vs. gemcitabine alone in advanced pancreatic carcinoma. Proc Am Soc Clin Oncol 2003; 22:250 (Abstract #1003).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.1003 , pp. 250
    • Heinemann, V.1    Quietzsch, D.2    Giesler, F.3
  • 30
    • 1642323465 scopus 로고    scopus 로고
    • A randomized phase 3 study comparing efficacy and safety of gemcitabine (GEM) and irinotecan (I), to GEM alone in patients (pts) with locally advanced or metastatic pancreatic cancer who have not received prior systemic therapy
    • Abstract
    • Rocha Lima CMS, Rotche R, Jeffery M, et al. A randomized phase 3 study comparing efficacy and safety of gemcitabine (GEM) and irinotecan (I), to GEM alone in patients (pts) with locally advanced or metastatic pancreatic cancer who have not received prior systemic therapy. Proc Am Soc Clin Oncol 2003; 22:251 (Abstract #1005).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.1005 , pp. 251
    • Rocha Lima, C.M.S.1    Rotche, R.2    Jeffery, M.3
  • 31
    • 85031369411 scopus 로고    scopus 로고
    • Louvet C, Labianca R, Hammel P, et al. GemOx (gemcitabine + oxaliplatin) versus Gem (gemcitabine) in non-resectable pancreatic adenocarcinoma: final results of the GERCOR/GISCAD Intergroup Phase III. Proc Am Soc Clin Oncol (post-meeting edition) 2004; 22 (Abstract #4008).
    • Louvet C, Labianca R, Hammel P, et al. GemOx (gemcitabine + oxaliplatin) versus Gem (gemcitabine) in non-resectable pancreatic adenocarcinoma: final results of the GERCOR/GISCAD Intergroup Phase III. Proc Am Soc Clin Oncol (post-meeting edition) 2004; 22 (Abstract #4008).
  • 32
    • 85031386764 scopus 로고    scopus 로고
    • Cheverton P, Friess H, Andras C, et al. Phase III results of exactecan (DX-8951f) versus gemcitabine (Gem) in chemotherapynaive patients with advanced pancreatic cancer (APC). Proc Am Soc Clin Oncol (post-meeting edition) 2004; 22 (Abstract #4005).
    • Cheverton P, Friess H, Andras C, et al. Phase III results of exactecan (DX-8951f) versus gemcitabine (Gem) in chemotherapynaive patients with advanced pancreatic cancer (APC). Proc Am Soc Clin Oncol (post-meeting edition) 2004; 22 (Abstract #4005).


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