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Volumn 61, Issue 2, 2001, Pages 179-189

Enzyme-catalyzed therapeutic agent (ECTA) design: Activation of the antitumor ECTA compound NB1011 by thymidylate synthase

(12) Lackey, David B a Groziak, Michael P b Sergeeva, Maria a Beryt, Malgorzata c Boyer, Christopher a Stroud, Robert M d Sayre, Peter d Park, John W d Johnston, Patrick e Slamon, Dennis c Shepard, H Michael a Pegram, Mark c

a NewBiotics Inc (United States)

b SRI INTERNATIONAL (United States)

c UNIVERSITY OF CALIFORNIA (United States)

d UNIVERSITY OF CALIFORNIA (United States)

e QUEEN'S UNIVERSITY BELFAST (United Kingdom)

Author keywords

Cancer; Chemotherapy; Drug resistance; Nucleoside analog; Phosphoramidate; Thymidylate synthase

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; FLOXURIDINE PHOSPHATE; FLUOROPYRIMIDINE; FLUOROURACIL; HOMOCYSTEINE; MERCAPTOETHANOL; NB 1011; PHOSPHORAMIDIC ACID; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CARCINOMA CELL; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVATION; DRUG DELIVERY SYSTEM; DRUG SENSITIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BROMODEOXYURIDINE; DEOXYURACIL NUCLEOTIDES; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MICE, NUDE; PRODRUGS; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035863169 PISSN: 00062952 EISSN: None Source Type: Journal
DOI: 10.1016/S0006-2952(00)00542-6 Document Type: Article

Times cited : (35)

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