A novel method for the introduction of fluorine into the purine 2-position: Synthesis of 2-fluoroadenosine and a formal synthesis of the antileukemic drug fludarabine

Synthesis

Volumn , Issue 18, 2006, Pages 2993-2995

  Brændvang, Morten ^a   Gundersen, Lise Lotte ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Anticancer agents; Fluorination; Nitration; Nucleosides; Purines

Indexed keywords

ANTICANCER AGENTS; FLUORINATION; NUCLEOSIDES; PURINES;

DRUG PRODUCTS; NITRATION; PHOSPHATES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

FLUORINE;

2 (2 FURYL) 9 (4 METHOXYPHENYLMETHYL) 2 NITRO 9H PURINE; 2 CHLORO 6 (2 FURYL) 9 (4 METHOXYPHENYLMETHYL) 9H PURINE; 2 FLUORO 6 (2 FURYL) 9 (4 METHOXYPHENYLMETHYL) 9H PURINE; 2 FLUOROADENOSINE; 2 FLUOROPURINE DERIVATIVE; ADENOSINE; ADENOSINE RECEPTOR; ADENYLATE CYCLASE; ANTILEUKEMIC AGENT; ANTIMETABOLITE; ANTIMYCOBACTERIAL AGENT; FLUDARABINE PHOSPHATE; FLUORINE; HEAT SHOCK PROTEIN 90; PURINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION;

EID: 33749536764     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-942544     Document Type: Article

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