Selective anti-tubercular purines: Synthesis and chemotherapeutic properties of 6-aryl- and 6-heteroaryl-9-benzylpurines

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6360-6373

  Brændvang, Morten ^a   Gundersen, Lise Lotte ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Antimycobacterial; Cross coupling; N Arylation; Purines

Indexed keywords

2 CHLORO 6 (4 METHOXYPHENYL) 9 (4 METHOXYPHENYLMETHYL) 9H PURINE; 2 CHLORO 9 (4 METHOXYPHENYLMETHYL) 6 (2 THIENYL) 9H PURINE; 6 (2 BENZO[B]FURYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (2 METHOXYPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (2 OXAZOLYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (2,4 DIMETHOXYPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (2,4 DIMETHYLPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (3 CHLOROPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (3 FURYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (3 METHOXYPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (3 NITROPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (3,4 DICHLOROPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (3,4 DIMETHYLPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 CHLOROPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 HYDROXYPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 METHOXY 2 METHYLPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 METHYLPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 N PROPOXYPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 N,N DIMETHYLAMINOPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 PHENOXYPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (4 TERT BUTYLPHENYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (5 METHOXY 2 FURYL) 9 (PHENYLMETHYL) 9H PURINE; 6 (5 METHYL 2 FURYL) 9 (PHENYLMETHYL) 9H PURINE; 6 BROMO 7 (PHENYLMETHYL) 7H PURINE; 6 BROMO 9 (PHENYLMETHYL) 9H PURINE; 9 (PHENYLMETHYL) 6 (2 THIASOLYL) 9H PURINE; 9 (PHENYLMETHYL) 6 (3 THIENYL) 9H PURINE; PURINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMOTHERAPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MAMMAL CELL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTITUBERCULAR AGENTS; CELL LINE; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PURINES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

ANIMALIA; MAMMALIA; MYCOBACTERIUM TUBERCULOSIS; NEGIBACTERIA; POSIBACTERIA;

EID: 27544509944     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.06.054     Document Type: Article

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