Synthesis of 5′-methylenearisteromycin and its 2-fluoro derivative with potent antimalarial activity due to inhibition of the parasite S-adenosylhomocysteine hydrolase

Organic and Biomolecular Chemistry

Volumn 3, Issue 7, 2005, Pages 1245-1251

  Takagi, Chieko ^a   Sukeda, Makoto ^a   Kim, Hye Sook ^b   Wataya, Yusuke ^b   Yabe, Saori ^c   Kitade, Yukio ^c   Matsuda, Akira ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELLS; ENZYME INHIBITION; ENZYME KINETICS; ENZYMES; METABOLISM; NUCLEIC ACIDS; REACTION KINETICS; STEREOCHEMISTRY; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL); TOXICITY;

ANTIMALARIAL AGENTS; CARBOCYLIC STRUCTURE; HYDROLASES; NUCLEOSIDES;

NITROGEN COMPOUNDS;

PLASMODIUM FALCIPARUM;

5' METHYLENEARISTEROMYCIN; 5'-METHYLENEARISTEROMYCIN; ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANTIMALARIAL AGENT; DRUG DERIVATIVE;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; IC 50; METABOLISM; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; SYNTHESIS;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTIMALARIALS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PLASMODIUM FALCIPARUM; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 17444393603     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b418829b     Document Type: Article

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