A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase

Journal of the American Chemical Society

Volumn 128, Issue 40, 2006, Pages 13216-13223

  Wang, Yi ^a   Scherperel, Gwynyth ^b   Roberts, Kade D ^b   Jones, A Daniel ^a,b   Reid, Gavin E ^a,b   Yan, Honggao ^a  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTATION; OXYGENATION; PROTONATION;

BIOSYNTHESIS; CATALYST ACTIVITY; SUBSTITUTION REACTIONS;

ENZYMES;

6 HYDROXYMETHYL 7,8 DIHYDROPTERIN; 7,8 DIHYDRONEOPTERIN; 7,8 DIHYDROXANTHOPTERIN; DIHYDRONEOPTERIN ALDOLASE; FOLIC ACID; NEOPTERIN; OXYGENASE; PHENYLALANINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; OXYGENATION; POINT MUTATION; PROTON TRANSPORT; REACTION ANALYSIS;

ALDEHYDE-LYASES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXYGEN; OXYGENASES; POINT MUTATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749528959     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja063455i     Document Type: Article

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