Stochastic monoallelic expression of IL-10 in T cells

Journal of Immunology

Volumn 177, Issue 8, 2006, Pages 5358-5364

  Calado, Dinis Pedro ^a,c   Paixão, Tiago ^a   Holmberg, Dan ^b   Haury, Matthias ^a,d  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^b UMEÅ UNIVERSITY   (Sweden)

^c CENTER FOR BLOOD RESEARCH   (United States)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; INTERLEUKIN 10; T LYMPHOCYTE RECEPTOR;

ACETYLATION; ALLELE; ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STATISTICAL ANALYSIS; T LYMPHOCYTE; TRANSCRIPTION INITIATION;

EID: 33749522704     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.8.5358     Document Type: Article

References (36)

1. Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170: 2081-2095.
2. Moore, K. W., R. de Waal Malefytqq, R. L. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19: 683-765.
3. Roers, A., L. Siewe, E. Strittmatter, M. Decken, D. Schluter, W. Stenzel, A. D. Gruber, T. Krieg, K. Rajewsky, and W. Muller. 2004. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J. Exp. Med. 200: 1289-1297.
4. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-274.
5. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195: 603-616.
6. Wakkach, A., N. Fournier, V. Brun, J. P. Breittmayer, F. Cottrez, and H. Groux. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18: 605-617.
7. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
8. Tone, M., M. J. Powell, Y. Tone, S. A. Thompson, and H. Waldmann. 2000. IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J. Immunol. 165: 286-291.
9. Wang, Z. Y., H. Sato, S. Kusam, S. Sehra, L. M. Toney, and A. L. Dent. 2005. Regulation of IL-10 gene expression in Th2 cells by Jun proteins. J. Immunol. 174: 2098-2105.
10. Grenningloh, R., B. Y. Kang, and I. C. Ho. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J. Exp. Med. 201: 615-626.
11. Im, S. H., A. Hueber, S. Monticelli, K. H. Kang, and A. Rao. 2004. Chromatin-level regulation of the IL-10 gene in T cells. J. Biol. Chem. 279: 46818-46825.
12. Saraiva, M., J. R. Christensen, A. V. Tsytsykova, A. E. Goldfeld, S. C. Ley, D. Kioussis, and A. O'Garra. 2005. Identification of a macrophage-specific chromatin signature in the IL-10 locus. J. Immunol. 175: 1041-1046.
13. Jones, E. A., and R. A. Flavell. 2005. Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene-cluster. J. Immunol. 175: 7437-7446.
14. + T cells. Science 281: 1352-1354.
15. Riviere, I., M. J. Sunshine, and D. R. Littman. 1998. Regulation of IL-4 expression by activation of individual alleles. Immunity 9: 217-228.
16. Hu-Li, J., C. Pannetier, L. Guo, M. Lohning, H. Gu, C. Watson, M. Assenmacher, A. Radbruch, and W. E. Paul. 2001. Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity 14: 1-11.
17. Hollander, G. A., S. Zuklys, C. Morel, E. Mizoguchi, K. Mobisson, S. Simpson, C. Terhorst, W. Wishart, D. E. Golan, A. K. Bhan, and S. J. Burakoff. 1998. Monoallelic expression of the interleukin-2 locus. Science 279: 2118-2121.
18. Naramura, M., R. J. Hu, and H. Gu. 1998. Mice with a fluorescent marker for interleukin 2 gene activation. Immunity 9: 209-216.
19. + T cell clones. J. Immunol. 171: 2349-2353.
20. Kelly, B. L., and R. M. Locksley. 2000. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J. Immunol. 165: 2982-2986.
21. Guo, L., J. Hu-Li, and W. E. Paul. 2005. Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13. Immunity 23: 89-99.
22. Goldmit, M., and Y. Bergman. 2004. Monoallelic gene expression: a repertoire of recurrent themes. Immunol. Rev. 200: 197-214.
23. Mostoslavsky, R., F. W. Alt, and K. Rajewsky. 2004. The lingering enigma of the allelic exclusion mechanism. Cell 118: 539-544.
24. Lohning, M., A. Richter, and A. Radbruch. 2002. Cytokine memory, of T helper lymphocytes. Adv. Immunol. 80: 115-181.
25. Lohning, M., A. Richter, T. Stamm, J. Hu-Li, M. Assenmacher, W. E. Paul, and A. Radbruch. 2003. Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation. Proc. Natl. Acad. Sci. USA 100: 12307-12312.
26. Bergqvist, I., B. Eriksson, M. Eriksson, and D. Holmberg. 1998. Transgenic Cre recombinase expression in germ cells and early embryogenesis directs homogeneous and ubiquitous deletion of loxP-flanked gene segments. FEBS Lett. 438: 76-80.
27. Chiodetti, L., D. L. Barber, and R. H. Schwartz. 2000. Biallelic expression of the IL-2 locus under optimal stimulation conditions. Eur. J. Immunol. 30: 2157-2163.
28. Fitzpatrick, D. R., and A. Kelso. 1999. Nature versus nurture in T cell cytokine production. J. Leukocyte Biol. 66: 869-875.
29. Mellor, J. 2005. The dynamics of chromatin remodeling at promoters. Mol. Cell 19: 147-157.
30. Sealy, L., and R. Chalkley. 1978. The effect of sodium butyrate on histone modification. Cell 14: 115-121.
31. Yoshida, M., M. Kijima, M. Akita, and T. Beppu. 1990. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265: 17174-17179.
32. Sokal, R. R., and J. Rohlf. 1969. Biometry-The Principles and Practice of Statistics in Biological Research. W. H. Freeman & Co., San Francisco.
33. Dong, J., C. Ivascu, F. Eckhardt, H.-D. Chang, C. Haefliger, L. Tykocinski, M. Rudwaleit, J. Sieper, A. Radbruch, and A. Thiel. 2005. Lack of linkage between DNA methylation and interleukin-10 gene expression. In 2005 Annual Meeting, May 12-16. Federation of Clinical Immunology Societies, Milwaukee, p. 107.
34. Guo, L., J. Hu-Li, J. Zhu, C. J. Watson, M. J. Difilippantonio, C. Pannetier, and W. E. Paul. 2002. In TH2 cells the 114 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc. Natl. Acad. Sci. USA 99: 10623-10628.
35. Powell, M. J., S. A. Thompson, Y. Tone, H. Waldmann, and M. Tone. 2000. Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region. J. Immunol. 165: 292-296.
36. Rouleau, M., F. Cottrez, M. Bigler, S. Antonenko, J. M. Carballido, A. Zlotnik, M. G. Roncarolo, and H. Groux. 1999. IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients. J. Immunol. 163: 1420-1427.